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The autotaxin-lysophosphatidic acid pathway in pathogenesis of rheumatoid arthritis

dc.contributor.authorOrosa Puente, Beatriz
dc.contributor.authorGarcía Pérez, Samuel
dc.contributor.authorConde Muro, Carmen 
dc.date.accessioned2023-06-27T07:24:08Z
dc.date.available2023-06-27T07:24:08Z
dc.date.issued2015-08-20
dc.identifier.issn0014-2999
dc.identifier.otherhttps://pubmed.ncbi.nlm.nih.gov/26297977/es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/17741
dc.description.abstract[EN] Lysophosphatidicacid (LPA )is a phospholipid that i smainly produced by the hydrolysis of lysopho- sphatidylcholine (LPC) by lysophospholipase D, which is also called autotaxin (ATX).LPA interacts with specific G-protein coupled receptors and is involved in the regulation of cellular survival, proliferation,differentiation and motility . LPA also has roles in several pathological disorders, such as cancer and pulmonary, dermal and renal fibrosis. The involvement of the ATX–LPA pathway has recently been demonstrated in inflammatory responses and apoptosis of fibroblast like synoviocytes (FLS) from patients with rheumatoid arthritis and during the development of experimental arthritis.This review summarises the current literature of the ATX–LPA pathway in rheumatoid arthritis.es
dc.description.sponsorshipInstituto de Salud Carlos III (ISCIII)es
dc.description.sponsorshipEuropean Regional Development Fund of the European Uniones
dc.language.isoenges
dc.subject.meshApoptosis*
dc.subject.meshSynoviocytes*
dc.subject.meshLysophospholipase*
dc.subject.meshSynovial Fluid*
dc.subject.meshArthritis, Experimental*
dc.subject.meshArthritis*
dc.subject.meshSynovial Membrane*
dc.subject.meshSignal Transduction*
dc.subject.meshPhosphoric Diester Hydrolases*
dc.subject.meshConflict of Interest*
dc.subject.meshArthritis, Rheumatoid*
dc.subject.meshRNA, Messenger*
dc.subject.meshLysophospholipids*
dc.titleThe autotaxin-lysophosphatidic acid pathway in pathogenesis of rheumatoid arthritises
dc.typeArtigoes
dc.identifier.doi10.1016/j-ejphar.2015.08.028
dc.identifier.pmid26297977
dc.journal.titleEuropean Journal of Pharmacologyes
dc.organizationServizo Galego de Saúde::Áreas Sanitarias (A.S.)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.organizationServizo Galego de Saúde::Áreas Sanitarias (A.S.)::Área Sanitaria de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostelaes
dc.page.initial228es
dc.page.final233es
dc.relation.projectIDISCIII/PI11/02197es
dc.relation.projectIDRD12/0009/0008 (RIER)es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S0014299915302028?via%3Dihubes
dc.rights.accessRightsopenAccesses
dc.subject.decsapoptosis*
dc.subject.decslíquido sinovial*
dc.subject.decsmembrana sinovial*
dc.subject.decsdiéster fosfórico hidrolasas*
dc.subject.decslisofosfolipasa*
dc.subject.decslisofosfolípidos*
dc.subject.decsartritis experimental*
dc.subject.decstransducción de señales*
dc.subject.decsartritis*
dc.subject.decsartritis reumatoide*
dc.subject.decsARN mensajero*
dc.subject.keywordIDISes
dc.subject.keywordCHUSes
dc.typefidesArtigo Científico (inclue Orixinal, Orixinal breve, Revisión Sistemática e Meta-análisis)es
dc.typesophosArtículo de Revisiónes
dc.volume.number765es


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Eur J Pharmacol . 2015 Oct 15;765:228-33

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