Saliva Gene Promoter Hypermethylation as a Biomarker in Oral Cancer
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Identificadores
URI: http://hdl.handle.net/20.500.11940/18445
PMID: 33947071
DOI: 10.3390/jcm10091931
ISSN: 2077-0383
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Fecha de publicación
2021Título de revista
Journal of Clinical Medicine
Tipo de contenido
Journal Article
Resumen
Oral carcinogenesis is a multistep process characterized by a summation of multiple genetic and epigenetic alterations in key regulatory genes. The silencing of genes by aberrant promoter hypermethylation is thought to be an important epigenetic event in cancer development and progression which has great potential as a biomarker for early diagnosis, tumor molecular subtyping, prognosis, monitoring, and therapy. Aberrant DNA methylation has been detected in different liquid biopsies, which may represent a potential alternative to solid biopsies. The detection of methylated genes in saliva may have clinical application for noninvasive oral cancer screening and early diagnosis. Here, we review the current evidence on gene promoter hypermethylation in saliva.
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