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Review of clinical studies comparing meningococcal serogroup C immune responses induced by MenACWY-TT and monovalent serogroup C vaccines
dc.contributor.author | Serra, L. | |
dc.contributor.author | Knuf, M. | |
dc.contributor.author | Martinón Torres, Federico | |
dc.contributor.author | Yi, K. | |
dc.contributor.author | Findlow, J. | |
dc.date.accessioned | 2024-01-02T10:03:04Z | |
dc.date.available | 2024-01-02T10:03:04Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 2164-5515 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/33606596 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/18469 | |
dc.description.abstract | Many countries are replacing meningococcal serogroup C (MenC) conjugate vaccines (MCCV) with quadrivalent conjugate (MenACWY) vaccines, such as MenACWY-TT (Nimenrix(R)). This review examined eight studies comparing MenC immune responses induced by MenACWY-TT and MCCV to determine if these data support these changes. MenC serum bactericidal antibody levels using human (hSBA) or rabbit complement (rSBA) were evaluated at ~1 month postvaccination. Overall, >/=98.4% of infants administered 2 + 1 MenACWY-TT or MCCV schedules had rSBA titers >/=1:8 postprimary and postbooster vaccination; hSBA titers >/=1:8 were similar. In toddlers administered single MenACWY-TT or MCCV doses, >/=97.3% had rSBA titers >/=1:8 postvaccination; percentages with hSBA titers >/=1:8 were higher post-MenACWY-TT. Of children and adolescents receiving primary and booster MenACWY-TT and MCCV, >/=98.6% had rSBA titers >/=1:8; all children receiving MenACWY-TT or MCCV booster had hSBA titers >/=1:8 postdosing. MenC immune responses induced by MenACWY-TT are robust and generally comparable/superior to MCCV, supporting changes to recommendations. | |
dc.language.iso | en | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Review of clinical studies comparing meningococcal serogroup C immune responses induced by MenACWY-TT and monovalent serogroup C vaccines | |
dc.type | Journal Article | es |
dc.authorsophos | Serra, L.;Knuf, M.;Martinón-Torres, F.;Yi, K.;Findlow, J. | |
dc.identifier.doi | 10.1080/21645515.2020.1855952 | |
dc.identifier.pmid | 33606596 | |
dc.identifier.sophos | 44288 | |
dc.issue.number | 7 | |
dc.journal.title | Human Vaccines & Immunotherapeutics | |
dc.organization | Servizo Galego de Saúde::Áreas Sanitarias (A.S.)::Área Sanitaria de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Pediatría | |
dc.organization | Servizo Galego de Saúde::Áreas Sanitarias (A.S.)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS) | |
dc.page.initial | 2205 | |
dc.page.final | 2215 | |
dc.rights.accessRights | openAccess | |
dc.subject.keyword | Área Sanitaria de Santiago de Compostela e Barbanza | es |
dc.subject.keyword | IDIS | es |
dc.subject.keyword | CHUS | |
dc.typefides | Artículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis) | es |
dc.typesophos | Artículo de Revisión | es |
dc.volume.number | 17 |