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Effectiveness of Safinamide over Mood in Parkinson's Disease Patients: Secondary Analysis of the Open-label Study SAFINONMOTOR
dc.contributor.author | LABANDEIRA GUERRA, CARMEN MARIA | |
dc.contributor.author | ALONSO LOSADA, MARIA GEMA | |
dc.contributor.author | Yañez Baña, Rosa María | |
dc.contributor.author | Cimas Hernando, M. I. | |
dc.contributor.author | Cabo López, Iria | |
dc.contributor.author | Paz González, José Manuel | |
dc.contributor.author | Gonzalez Palmás, María José | |
dc.contributor.author | Martínez Miró, Cristina | |
dc.contributor.author | Santos García, Diego | |
dc.date.accessioned | 2024-01-02T10:03:14Z | |
dc.date.available | 2024-01-02T10:03:14Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0741-238X | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/34523075 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/18476 | |
dc.description.abstract | INTRODUCTION: Mood disorders are frequent in Parkinson's disease (PD) and a favorable effect of safinamide on mood has been observed. We aimed to analyze the effectiveness of safinamide on mood as a secondary objective from the SAFINONMOTOR (an open-label study of the effectiveness of SAFInamide on NON-MOTOR symptoms in patients with Parkinson's disease) study. METHODS: SAFINONMOTOR is a prospective open-label single-arm study conducted in five centers from Spain. Patients with PD were required to have at baseline a Non-Motor Symptoms Scale (NMSS) total score of at least 40. In this analysis, the changes from V1 (baseline) to V4 (6 months +/- 1 month) in the BDI-II (Beck Depression Inventory-II), NMSS mood/apathy domain, and PDQ-39 (Parkinson's Disease Questionnaire-39) emotional well-being domain were analyzed. Depression was identified and classified (DSM-IV and Judd criteria) at baseline and at the end of follow-up as major depression (MD), minor depression (mD), subthreshold depression (subD), and non-depression (nonD). RESULTS: Fifty patients with PD were included (age 68.5 +/- 9.12 years; 58% women; 6.4 +/- 5.1 years from diagnosis) and 44 patients (88%) completed the follow-up at 6 months. The BDI-II total score was reduced by 35.9% (from 15.88 +/- 10.46 at V1 to 10.18 +/- 6.76 at V4; p < 0.0001). A significant decrease in the NMSS mood/apathy domain and PDQ-39 emotional well-being domain was observed as well (p < 0.0001). At baseline, 52% of the patients presented MD, 34% mD, 12% subD, and 2% nonD whereas at V4 the percentages were 31.8%, 34.1%, 22.7%, and 11.4%, respectively (p = 0.029). CONCLUSIONS: Safinamide improves mood in patients with PD at 6 months. | |
dc.language.iso | en | |
dc.rights | Atribución-NoComercial 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | Effectiveness of Safinamide over Mood in Parkinson's Disease Patients: Secondary Analysis of the Open-label Study SAFINONMOTOR | |
dc.type | Journal Article | es |
dc.authorsophos | Labandeira, C. M.;Alonso Losada, M. G.;Yáñez Baña, R.;Cimas Hernando, M. I.;Cabo López, I.;Paz González, J. M.;Gonzalez Palmás, M. J.;Martínez Miró, C.;Santos García, D. | |
dc.identifier.doi | 10.1007/s12325-021-01873-w | |
dc.identifier.pmid | 34523075 | |
dc.identifier.sophos | 43242 | |
dc.issue.number | 10 | |
dc.journal.title | ADVANCES IN THERAPY | |
dc.organization | Servizo Galego de Saúde::Áreas Sanitarias (A.S.)::Área Sanitaria de Ourense, Verín e O Barco de Valdeorras - Complexo Hospitalario Universitario de Ourense | |
dc.organization | Servizo Galego de Saúde::Áreas Sanitarias (A.S.)::Área Sanitaria de A Coruña - Complexo Hospitalario Universitario de A Coruña::Neuroloxía | |
dc.organization | Servizo Galego de Saúde::Áreas Sanitarias (A.S.)::Área Sanitaria de Ourense, Verín e O Barco de Valdeorras::Complexo Hospitalario Universitario de Ourense::Neuroloxía | |
dc.organization | Servizo Galego de Saúde::Áreas Sanitarias (A.S.)::Área Sanitaria de Vigo - Complexo Hospitalario Universitario de Vigo::Neuroloxía | |
dc.page.initial | 5411 | |
dc.rights.accessRights | openAccess | |
dc.subject.keyword | CHUO | es |
dc.subject.keyword | CHUAC | es |
dc.subject.keyword | CHUVI | es |
dc.subject.keyword | CHUP | |
dc.typefides | Artículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis) | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 38 |