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Predicted concentrations of antineoplastic drugs in the aquatic environment: The case of Ría de Vigo (NW, Spain)
dc.contributor.author | Couñago Fernández, Moisés | |
dc.contributor.author | Otero, Pablo | |
dc.contributor.author | Samartín Ucha, Marisol | |
dc.contributor.author | Paradela Carreiro, Adolfo | |
dc.contributor.author | Paradela Carreiro, Adolfo | |
dc.contributor.author | Muniategui-Lorenzo, Soledad | |
dc.contributor.author | Martínez Lopez de Castro, Noemi | |
dc.date.accessioned | 2024-05-27T07:59:24Z | |
dc.date.available | 2024-05-27T07:59:24Z | |
dc.date.issued | 2024-05-03 | |
dc.identifier.other | https://pubmed.ncbi.nlm.nih.gov/38703630/ | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/18781 | |
dc.description.abstract | The European Medicines Agency (EMA) mandates Environmental Risk Assessments (ERAs) since 2006 to determine potential risks of new marketed medicines. Drugs with a Predicted Environmental Concentration (PEC) in inland surface waters exceeding 0.01 μg L−1 require further environmental risk assessment. PEC may be refined based on prevalence data and/or based on the treatment regimen. In this study, based on EMA regulations, refined PEC of 108 antineoplastic drugs in coastal waters were determined based on the consumption in a coastal health area during 2021, identifying six drugs with potential environmental risk in surface waters (hydroxyurea, capecitabine, abiraterone, ibrutinib, imatinib and 5-fluorouracil) and two in marine ecosystem (hydroxyurea and capecitabine). Comparison of these refined PECs with data from marketing laboratories revealed significant disparities, suggesting the need for regular updates, especially with changes in drug indications or financing. Notably, the identified drugs are not yet on the main reference lists of emerging contaminants. | es |
dc.language.iso | eng | es |
dc.subject.mesh | Risk Assessment | * |
dc.subject.mesh | Environmental Monitoring | * |
dc.subject.mesh | Pharmacovigilance | * |
dc.subject.mesh | Aquatic Organisms | * |
dc.subject.mesh | Antineoplastic Agents | * |
dc.title | Predicted concentrations of antineoplastic drugs in the aquatic environment: The case of Ría de Vigo (NW, Spain) | es |
dc.title.alternative | Predicción de concentraciones de fármacos antineoplásicos en el medio acuático: El caso de la Ría de Vigo (NO, España) | es |
dc.type | Artigo | es |
dc.identifier.doi | 10.1016/j.marpolbul.2024.116399 | |
dc.identifier.pmid | 38703630 | |
dc.journal.title | Marine Pollution Bulletin | es |
dc.organization | Servizo Galego de Saúde::Áreas Sanitarias (A.S.)::Área Sanitaria de Vigo - Complexo Hospitalario Universitario de Vigo | es |
dc.organization | Servizo Galego de Saúde::Áreas Sanitarias (A.S.)::Instituto de Investigación Sanitaria Galicia Sur ((IISGS) | es |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0025326X2400376X?via%3Dihub | es |
dc.rights.accessRights | openAccess | es |
dc.subject.decs | farmacovigilancia | * |
dc.subject.decs | evaluación de riesgos | * |
dc.subject.decs | monitorización del ambiente | * |
dc.subject.decs | organismos acuáticos | * |
dc.subject.decs | antineoplásicos | * |
dc.subject.keyword | CHUVI | es |
dc.subject.keyword | IISGS | es |
dc.typefides | Artigo Científico (inclue Orixinal, Orixinal breve, Revisión Sistemática e Meta-análisis) | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 203 | es |
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