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dc.contributor.authorRaposeiras Roubín, Sergio 
dc.contributor.authorRodiño Janeiro, Bruno K
dc.contributor.authorParadela Dobarro, Beatriz
dc.contributor.authorGrigorian Shamagian, Lilian
dc.contributor.authorGarcía Acuña, José María 
dc.contributor.authorAguiar Souto, Pablo 
dc.contributor.authorAguiar Souto, Pablo 
dc.contributor.authorJacquet Hervet, M.
dc.contributor.authorReino Maceiras, Maria Victoria 
dc.contributor.authorGonzález Juanatey, José Ramón 
dc.contributor.authorÁlvarez Castro, Ezequiel
dc.date.accessioned2017-06-07T07:02:03Z
dc.date.available2017-06-07T07:02:03Z
dc.date.issued2013
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/20.500.11940/1879
dc.description.abstractObjective: Advanced glycation end products (AGEs) have pathophysiological implications in cardiovascular diseases. The aim of our study was to evaluate the prognostic value of fluorescent AGEs and its soluble receptor (sRAGE) in the context of acute coronary syndrome (ACS), both in-hospital phase and follow-up period. Methods: A prospective clinical study was performed in patients with debut's ACS. The endpoints were the development of cardiac events (cardiac deaths, re-infarction and new-onset heart failure) during in-hospital phase and follow-up period (366 days, inter-quartile range: 273-519 days). 215 consecutive ACS patients admitted to the coronary care unit (62.7±13.0 years, 24.2% female) were included. 47.4% had a diagnosis of ST segment elevation myocardial infarction. AGEs and sRAGE were analysed by fluorescence spectroscopy and competitive ELISA, respectively. Risk scores (GRACE, TIMI, PURSUIT) were calculated retrospectively using prospective data. The complexity of coronary artery disease was evaluated by SYNTAX score. Results: The mean fluorescent AGEs and sRAGE levels were 57.7±45.1 AU and 1045.4±850.0 pg/mL, respectively. 19 patients presented cardiac events during in-hospital phase and 29 during the follow-up. In-hospital cardiac events were significantly associated with higher sRAGE levels (p = 0.001), but not long-term cardiac events (p = 0.365). Regarding fluorescent AGE the opposite happened. After multivariate analysis correcting by gender, left ventricular ejection fraction, glucose levels, haemoglobin, GRACE and SYNTAX scores, sRAGE was significantly associated with in-hospital prognosis, whereas fluorescent AGEs was significantly associated with long-term prognosis. Conclusions: We conclude that elevated values of sRAGE are associated with worse in-hospital prognosis, whereas high fluorescent AGE levels are associated with more follow-up events.
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshAcute Coronary Syndrome 
dc.subject.meshGlycation End Products, Advanced
dc.subject.meshReceptors, Immunologic
dc.titleFluorescent Advanced Glycation End Products and Their Soluble Receptor: The Birth of New Plasmatic Biomarkers for Risk Stratification of Acute Coronary Syndrome
dc.typeArtigoes
dc.authorsophosRaposeiras-Roubín
dc.authorsophosRodiño-Janeiro, B. K. ;Paradela-Dobarro, B.;Grigorian-Shamagian, L.;García-Acuña, J. M.;Aguiar-Souto, P.;Jacquet-Hervet, M.
dc.authorsophosReino-Maceiras, M. V. ;González-Juanatey, J. R.
dc.authorsophosÁlvarez, E.
dc.identifier.doi10.1371/journal.pone.0074302
dc.identifier.isi324408400063
dc.identifier.pmid24058542
dc.identifier.sophos12320
dc.issue.number9
dc.journal.titlePLoS One
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago - Complexo Hospitalario Universitario de Santiago::Cardioloxía
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Vigo - Complexo Hospitalario Universitario de Vigo::Cardioloxía
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago
dc.rights.accessRightsopenAccess
dc.subject.decsReceptores Inmunológicos
dc.subject.decsProductos Finales de Glicación Avanzada
dc.subject.decsSíndrome Coronario Agudo
dc.typesophosArtículo Original
dc.volume.number8


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