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dc.contributor.authorMoscoso, I.
dc.contributor.authorCebro Márquez, María
dc.contributor.authorMartínez Gómez, Álvaro 
dc.contributor.authorAbou Jokh Casas, Charigan
dc.contributor.authorMartínez Monzonís, Maria Amparo 
dc.contributor.authorMartínez Sande, Jose Luis 
dc.contributor.authorGonzález Melchor, Laila
dc.contributor.authorGarcía Seara, Javier 
dc.contributor.authorFernández López, Jesus Alberto 
dc.contributor.authorMoraña Fernández, Sandra
dc.contributor.authorGonzález Juanatey, José Ramón 
dc.contributor.authorRodríguez Mañero, Moises 
dc.contributor.authorLage Fernández, Ricardo
dc.date.accessioned2025-02-18T11:35:15Z
dc.date.available2025-02-18T11:35:15Z
dc.date.issued2022
dc.identifier.issn2073-4409
dc.identifier.urihttp://hdl.handle.net/20.500.11940/19542
dc.description.abstractCardiac resynchronization therapy represents a therapeutic option for heart failure drug-refractory patients. However, due to the lack of success in 30% of the cases, there is a demand for an in-depth analysis of individual heterogeneity. In this study, we aimed to evaluate the prognostic value of circulating miRNA differences. Responder patients were defined by a composite endpoint of the presence of left ventricular reverse remodelling (a reduction ≥15% in telesystolic volume and an increment ≥10% in left ventricular ejection fraction). Circulating miRNAs signature was analysed at the time of the procedure and at a 6-month follow-up. An expression analysis showed, both at baseline and at follow-up, differences between responders and non-responders. Responders presented lower baseline expressions of miR-499, and at follow-up, downregulation of miR-125b-5p, both associated with a significant improvement in left ventricular ejection fraction. The miRNA profile differences showed a marked sensitivity to distinguish between responders and non-responders. Our data suggest that miRNA differences might contribute to prognostic stratification of patients undergoing cardiac resynchronization therapy and suggest that preimplant cardiac context as well as remodelling response are key to therapeutic success.
dc.language.isoenes
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleCirculating miR-499a and miR-125b as Potential Predictors of Left Ventricular Ejection Fraction Improvement after Cardiac Resynchronization Therapy
dc.typeJournal Articlees
dcterms.bibliographicCitationMoscoso I, Cebro-Márquez M, Martínez-Gómez Á, Abou-Jokh C, Martínez-Monzonís MA, Martínez-Sande JL, et al. Circulating miR-499a and miR-125b as Potential Predictors of Left Ventricular Ejection Fraction Improvement after Cardiac Resynchronization Therapy. Cells. 2022;11(2).
dc.authorsophosMoscoso, R. I.;Cebro-Márquez, M.;Martínez-Gómez, Á;Abou-Jokh, C.;Martínez-Monzonís, M. A.;Martínez-Sande, J. L.;González-Melchor, L.;García-Seara, J.;Fernández-López, X. A.;Moraña-Fernández, S.;González-Juanatey, J. R.;Rodríguez-Mañero, M.;Lage
dc.identifier.doi10.3390/CELLS11020271
dc.identifier.sophos61ff065a13638e1cfc277668
dc.issue.number2
dc.journal.titleCells
dc.relation.publisherversionhttps://mdpi-res.com/d_attachment/cells/cells-11-00271/article_deploy/cells-11-00271-v2.pdf?version=1642145993es
dc.rights.accessRightsopenAccess
dc.subject.keywordAS Santiagoes
dc.subject.keywordIDISes
dc.subject.keywordAS Ferroles
dc.subject.keywordCHUFes
dc.subject.keywordAS Lugoes
dc.subject.keywordHULAes
dc.subject.keywordCHUSes
dc.volume.number11


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