Mostrar el registro sencillo del ítem

Elevated plasma levels of IP-10 and MIG are early predictors of loss of control among elite HIV controllers

dc.contributor.authorPoveda López, Eva 
dc.contributor.authorFitzgerald, Wendy
dc.contributor.authorAlonso-Domínguez, Jacobo
dc.contributor.authorAguayo-Arjona, José
dc.contributor.authorMariño Callejo, Ana Isabel 
dc.contributor.authorÁlvarez Díaz, Hortensia 
dc.contributor.authorValcarcel García, María Ángeles 
dc.contributor.authorPerez Gonzalez, Alexandre
dc.contributor.authorRuiz-Mateos, Ezequiel
dc.contributor.authorMargolis, Leonid
dc.contributor.authorLederman, Michael M
dc.contributor.authorFreeman, Michael L
dc.date.accessioned2025-03-26T08:40:10Z
dc.date.available2025-03-26T08:40:10Z
dc.date.issued2024-08-29
dc.identifier.urihttp://hdl.handle.net/20.500.11940/19785
dc.description.abstractPlasma cytokine levels were quantified among 30 persons with HIV (PWH) identified as elite controllers (15 transient controllers [studied a median of 1.38 years before losing viral control] and 15 persistent controllers). Thirty antiretroviral therapy (ART)-naive PWH, 30 ART-treated PWH with undetectable viremia, and 30 HIV-uninfected controls also were studied. Higher levels of cytokines were recognized among PWH than among controls, with EC displaying the highest levels. Elevated levels of IP-10 and MIG were identified among transient controllers as predictors of the loss of viral control. These findings offer feasible biomarkers for predicting virologic outcome and loss of control in EC.es
dc.description.sponsorshipInstituto de Salud Carlos III (ISCIII)es
dc.description.sponsorshipCase Western Reserve University Rustbelt Center for AIDS Researches
dc.description.sponsorshipEunice Kennedy Shriver National Institute of Child Health and Human Developmentes
dc.language.isoenges
dc.relation.isreferencedbyhttps://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1446730/fulles
dc.subject.meshViral Load *
dc.subject.meshHIV Long-Term Survivors *
dc.subject.meshAged *
dc.subject.meshUnited States *
dc.subject.meshAdult *
dc.subject.meshHumans *
dc.subject.meshHIV *
dc.subject.meshMiddle Aged *
dc.subject.meshHIV Infections *
dc.subject.meshChemokine CXCL9 *
dc.subject.meshMale *
dc.subject.meshFemale *
dc.subject.meshElite Controllers *
dc.subject.meshChemokine CXCL10 *
dc.subject.meshHIV-1 *
dc.subject.meshBrazil *
dc.titleElevated plasma levels of IP-10 and MIG are early predictors of loss of control among elite HIV controllerses
dc.typeArtigoes
dc.identifier.doi10.3389/fimmu.2024.1446730
dc.identifier.essn1664-3224
dc.identifier.pmid39267749
dc.journal.titleFrontiers in immunologyes
dc.organizationServizo Galego de Saúde::Áreas Sanitarias (A.S.)::Instituto de Investigación Sanitaria Galicia Sur ((IISGS)es
dc.organizationServizo Galego de Saúde::Áreas Sanitarias (A.S.)::Área Sanitaria de Ferrol – Complexo Hospitalario Universitario de Ferrol::Medicina Internaes
dc.organizationServizo Galego de Saúde::Áreas Sanitarias (A.S.)::Área Sanitaria de Vigo - Complexo Hospitalario Universitario de Vigo::Medicina Internaes
dc.page.initial1446730es
dc.relation.projectIDIISCIII/AES2016/02159es
dc.relation.projectIDIISCIII/AES2018/00034es
dc.relation.projectIDIISCIII/AES2019/00747es
dc.relation.projectIDIISCIII/AES2019/01127es
dc.relation.projectIDIISCIII/AES2022/01341es
dc.relation.projectIDIISCIII/AES2022/01796es
dc.relation.projectIDIISCIII/AES2020/00243es
dc.relation.projectIDIISCIII/RD16/0025/0026es
dc.relation.projectIDIISCIII/RD16/0025/0020es
dc.relation.projectIDCase Western Reserve University Rustbelt Center for AIDS Research (AI036219)es
dc.relation.projectIDEunice Kennedy Shriver National Institute of Child Health and Human Development (Intramural Program ZIA HD008968-05)es
dc.rights.accessRightsopenAccesses
dc.subject.decsadulto *
dc.subject.decscarga viral *
dc.subject.decsinfecciones por VIH *
dc.subject.decshumanos *
dc.subject.decsanciano *
dc.subject.decsquimiocina CXCL9 *
dc.subject.decsquimiocina CXCL10 *
dc.subject.decsmediana edad *
dc.subject.decsVIH *
dc.subject.decsVIH-1 *
dc.subject.keywordIISGSes
dc.subject.keywordCHUFes
dc.typefidesArtigo Científico (inclue Orixinal, Orixinal breve, Revisión Sistemática e Meta-análisis)es
dc.typesophosArtículo Originales
dc.volume.number15es


Ficheros en el ítem

Descargar/
Nombre:
39267749-full.pdf
Tamaño:
715.0Kb
Formato:
PDF
Descripción:
Front Immunol . 2024 Aug 29:15:1446730

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem