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dc.contributor.authorGómez Carballa, Alberto
dc.contributor.authorPardo Seco, Jacobo José
dc.contributor.authorFachal Vilar, Laura
dc.contributor.authorVega Gliemmo, Ana
dc.contributor.authorCebey López, Miriam
dc.contributor.authorMartinon Torres, Nazareth 
dc.contributor.authorMartinón Torres, Federico 
dc.contributor.authorSalas Ellacuriaga, Antonio
dc.date.accessioned2017-06-07T07:02:45Z
dc.date.available2017-06-07T07:02:45Z
dc.date.issued2013
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/20.500.11940/2002
dc.description.abstractIn agreement with historical documentation, several genetic studies have revealed ancestral links between the European Romani and India. The entire mitochondrial DNA (mtDNA) of 27 Spanish Romani was sequenced in order to shed further light on the origins of this population. The data were analyzed together with a large published dataset (mainly hypervariable region I [HVS-I] haplotypes) of Romani (N=1,353) and non-Romani worldwide populations (N>150,000). Analysis of mitogenomes allowed the characterization of various Romani-specific clades. M5a1b1a1 is the most distinctive European Romani haplogroup; it is present in all Romani groups at variable frequencies (with only sporadic findings in non-Romani) and represents 18% of their mtDNA pool. Its phylogeographic features indicate that M5a1b1a1 originated 1.5 thousand years ago (kya; 95% CI: 1.3-1.8) in a proto-Romani population living in Northwest India. U3 represents the most characteristic Romani haplogroup of European/Near Eastern origin (12.4%); it appears at dissimilar frequencies across the continent (Iberia: ≈ 31%; Eastern/Central Europe: ≈ 13%). All U3 mitogenomes of our Iberian Romani sample fall within a new sub-clade, U3b1c, which can be dated to 0.5 kya (95% CI: 0.3-0.7); therefore, signaling a lower bound for the founder event that followed admixture in Europe/Near East. Other minor European/Near Eastern haplogroups (e.g. H24, H88a) were also assimilated into the Romani by introgression with neighboring populations during their diaspora into Europe; yet some show a differentiation from the phylogenetically closest non-Romani counterpart. The phylogeny of Romani mitogenomes shows clear signatures of low effective population sizes and founder effects. Overall, these results are in good agreement with historical documentation, suggesting that cultural identity and relative isolation have allowed the Romani to preserve a distinctive mtDNA heritage, with some features linking them unequivocally to their ancestral Indian homeland.
dc.description.sponsorshipMinisterio de Ciencia e Innovación
dc.description.sponsorshipXunta de Galicia, Plan Galego IDT
dc.description.sponsorshipInstituto Carlos III
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshDNA, Mitochondrial
dc.subject.meshEuropean Continental Ancestry Group
dc.subject.meshGenome, Mitochondrial
dc.subject.meshPhylogeography
dc.subject.meshPhylogeny
dc.subject.meshFilogenia
dc.titleIndian signatures in the westernmost edge of the European Romani diaspora: new insight from mitogenomes
dc.typeArtigoes
dc.authorsophosGómez-Carballa, A.
dc.authorsophosPardo-Seco, J.
dc.authorsophosFachal, L.
dc.authorsophosVega, A.
dc.authorsophosCebey, M.
dc.authorsophosMartinón-Torres, N.
dc.authorsophosMartinón-Torres, F.
dc.authorsophosSalas, A.
dc.identifier.doi10.1371/journal.pone.0075397
dc.identifier.isi325894100004
dc.identifier.pmid24143169
dc.identifier.sophos12501
dc.issue.number10
dc.journal.titlePLoS One
dc.organizationConsellería de Sanidade::Fundación pública Galega de Medicina Xenómica
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago - Complexo Hospitalario Universitario de Santiago::Pediatría
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago
dc.page.initiale75397
dc.relation.projectIDMinisterio de Ciencia e Innovación/ (SAF 2008-0297)
dc.relation.projectIDXunta de Galicia, Plan Galego IDT/EM 2012/045)
dc.relation.projectIDXunta de Galicia, Consellería de Sanidade/(RHI07/2-intensificación actividad investigadora and 10PXIB918184PR)
dc.relation.projectIDInstituto Carlos III (intensificación de la actividad investigadora)
dc.relation.projectIDFondo de Investigación Sanitaria (FIS; PI070069 and PI1000540)
dc.relation.projectIDI+D+I and FEDER (F.M.T.)
dc.rights.accessRightsopenAccess
dc.subject.decsADN Mitocondrial
dc.subject.decsGrupo de Ascendencia Continental Europea
dc.subject.decsGenoma Mitocondrial
dc.subject.decsFilogeografía
dc.typesophosArtículo Original
dc.volume.number8


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