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Molecular Recognition by Pillar[5]arenes: Evidence for Simultaneous Electrostatic and Hydrophobic Interactions

dc.contributor.authorGonzález Gómez, Borja
dc.contributor.authorGarcía-Río, L.
dc.contributor.authorBasílio, N.
dc.contributor.authorMejuto, J.C.
dc.contributor.authorSimal Gándara, Jesús
dc.date.accessioned2025-08-14T11:50:32Z
dc.date.available2025-08-14T11:50:32Z
dc.date.issued2022
dc.identifier.citationGómez-González B, García-Río L, Basílio N, Mejuto JC, Simal-Gandara J. Molecular Recognition by Pillar[5]arenes: Evidence for Simultaneous Electrostatic and Hydrophobic Interactions. Pharmaceutics. 2022;14(1).
dc.identifier.issn1999-4923
dc.identifier.otherhttps://portalcientifico.sergas.gal/documentos/61f5a478e75a9821fbe80333*
dc.identifier.urihttp://hdl.handle.net/20.500.11940/20415
dc.description.abstractThe formation of inclusion complexes between alkylsulfonate guests and a cationic pil-lar[5]arene receptor in water was investigated by NMR and ITC techniques. The results show the formation of host-guest complexes stabilized by electrostatic interactions and hydrophobic effects with binding constants of up to 107 M?1 for the guest with higher hydrophobic character. Structurally, the alkyl chain of the guest is included in the hydrophobic aromatic cavity of the macrocycle while the sulfonate groups are held in the multicationic portal by ionic interactions.en
dc.description.sponsorshipFundingFinancial support from the Ministerio de Economia y Competitividad of Spain (project CTQ2017-84354-P), Xunta de Galicia (GR 2007/085 and ED431C2018/42-GRC) and the European Regional Development Fund (ERDF) is gratefully acknowledged. This work was also supported by the Associate Laboratory for Green Chemistry-LAQV which is financed by national funds from FCT/MCTES (UIDB/50006/2020). N.B. acknowledges the FCT/MCTES for the research contract CEECIND/00466/2017.en
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleMolecular Recognition by Pillar[5]arenes: Evidence for Simultaneous Electrostatic and Hydrophobic Interactions*
dc.typeArticleen
dc.authorsophosGómez-González, J. B.
dc.authorsophosGarcía-Río, L.
dc.authorsophosBasílio, N.
dc.authorsophosMejuto, J. C.
dc.authorsophosSimal, Gandara
dc.identifier.doi10.3390/pharmaceutics14010060
dc.identifier.sophos61f5a478e75a9821fbe80333
dc.issue.number1
dc.journal.titlePharmaceutics*
dc.page.initialnull
dc.relation.projectIDMinisterio de Economia y Competitividad of Spain [CTQ2017-84354-P]; Xunta de Galicia [GR 2007/085, ED431C2018/42-GRC]; European Regional Development Fund (ERDF); national funds from FCT/MCTES [UIDB/50006/2020]; FCT/MCTES [CEECIND/00466/2017]
dc.relation.publisherversionhttps://www.mdpi.com/1999-4923/14/1/60/pdf?version=1640683895;https://mdpi-res.com/d_attachment/pharmaceutics/pharmaceutics-14-00060/article_deploy/pharmaceutics-14-00060.pdf?version=1640683895es
dc.rights.accessRightsopenAccess
dc.subject.keywordAS Lugoes
dc.subject.keywordHULAes
dc.subject.keywordIDISes
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)es
dc.typesophosArtículo Originales
dc.volume.number14


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