Mostrar el registro sencillo del ítem

Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases

dc.contributor.authorDiz-Chaves, Y.
dc.contributor.authorMastoor, Z.
dc.contributor.authorSpuch Calvar, Carlos
dc.contributor.authorGonzález-Matías, L.C.
dc.contributor.authorMallo, F.
dc.date.accessioned2025-08-26T09:27:03Z
dc.date.available2025-08-26T09:27:03Z
dc.date.issued2022
dc.identifier.citationDiz-Chaves Y, Mastoor Z, Spuch C, González-Matías LC, Mallo F. Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases. International journal of molecular sciences. NLM (Medline); 2022;23(17).
dc.identifier.issn1422-0067
dc.identifier.otherhttps://portalcientifico.sergas.gal/documentos/632656abd50fae52cd31b2e6*
dc.identifier.urihttp://hdl.handle.net/20.500.11940/20650
dc.description.abstractThe glucagon-like peptide-1 (GLP-1) is a pleiotropic hormone well known for its incretin effect in the glucose-dependent stimulation of insulin secretion. However, GLP-1 is also produced in the brain and displays a critical role in neuroprotection and inflammation by activating the GLP-1 receptor signaling pathways. Several studies in vivo and in vitro using preclinical models of neurodegenerative diseases show that GLP-1R activation has anti-inflammatory properties. This review explores the molecular mechanistic action of GLP-1 RAS in relation to inflammation in the brain. These findings update our knowledge of the potential benefits of GLP-1RAS actions in reducing the inflammatory response. These molecules emerge as a potential therapeutic tool in treating neurodegenerative diseases and neuroinflammatory pathologies.en
dc.description.sponsorshipThe authors have financial support from the European Union Grant Alehoop (H2020BBIJTI-2019-887259). And from the Xunta de Galicia (Centro singular de Investigacion de Galicia accreditation 2016-2019), ED431G/02.en
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleAnti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases*
dc.typeReviewen
dc.authorsophosDiz-Chaves, F. Y.
dc.authorsophosMastoor, Z.
dc.authorsophosSpuch, C.
dc.authorsophosGonzález-Matías, L. C.
dc.authorsophosMallo
dc.identifier.doi10.3390/ijms23179583
dc.identifier.sophos632656abd50fae52cd31b2e6
dc.issue.number17
dc.journal.titleInternational journal of molecular sciences*
dc.relation.projectIDEuropean Union [H2020BBIJTI-2019-887259]; Xunta de Galicia [ED431G/02]
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/23/17/9583/pdf?version=1661494533;https://mdpi-res.com/d_attachment/ijms/ijms-23-09583/article_deploy/ijms-23-09583-v2.pdf?version=1661494533es
dc.rights.accessRightsopenAccess
dc.subject.keywordIISGSes
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)es
dc.typesophosArtículo de Revisiónes
dc.volume.number23


Ficheros en el ítem

Descargar/
Nombre:
586.pdf
Tamaño:
1.649Mb
Formato:
PDF
Descripción:
Diz-Chaves Y, Mastoor Z, Spuch C, González-Matías LC, Mallo F. Anti-Inflammatory ...

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Atribución 4.0 Internacional
Excepto si se señala otra cosa, la licencia del ítem se describe como Atribución 4.0 Internacional