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Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers

dc.contributor.authorJansen, I.E.
dc.contributor.authorvan der Lee, S.J.
dc.contributor.authorGomez-Fonseca, D.
dc.contributor.authorde Rojas, I.
dc.contributor.authorDalmasso, M.C.
dc.contributor.authorGrenier-Boley, B.
dc.contributor.authorZettergren, A.
dc.contributor.authorMishra, A.
dc.contributor.authorAli, M.
dc.contributor.authorAndrade, V.
dc.contributor.authorBellenguez, C.
dc.contributor.authorKleineidam, L.
dc.contributor.authorKüçükali, F.
dc.contributor.authorSung, Y.J.
dc.contributor.authorTesí, N.
dc.contributor.authorVromen, E.M.
dc.contributor.authorWightman, D.P.
dc.contributor.authorAlcolea, D.
dc.contributor.authorAlegret, M.
dc.contributor.authorAlvarez, I.
dc.contributor.authorAmouyel, P.
dc.contributor.authorAthanasiu, L.
dc.contributor.authorBahrami, S.
dc.contributor.authorBailly, H.
dc.contributor.authorBelbin, O.
dc.contributor.authorBergh, S.
dc.contributor.authorBertram, L.
dc.contributor.authorBiessels, G.J.
dc.contributor.authorBlennow, K.
dc.contributor.authorBlesa, R.
dc.contributor.authorBoada, M.
dc.contributor.authorBoland, A.
dc.contributor.authorBuerger, K.
dc.contributor.authorCarracedo Álvarez, Ángel
dc.contributor.authorCervera-Carles, L.
dc.contributor.authorChene, G.
dc.contributor.authorClaassen, J.A.H.R.
dc.contributor.authorDebette, S.
dc.contributor.authorDeleuze, J.-F.
dc.contributor.authorde Deyn, P.P.
dc.contributor.authorDiehl-Schmid, J.
dc.contributor.authorDjurovic, S.
dc.contributor.authorDols-Icardo, O.
dc.contributor.authorDufouil, C.
dc.contributor.authorDuron, E.
dc.contributor.authorDüzel, E.
dc.contributor.authorFladby, T.
dc.contributor.authorFortea, J.
dc.contributor.authorFrölich, L.
dc.contributor.authorGarcía-González, P.
dc.contributor.authorGarcia-Martinez, M.
dc.contributor.authorGiegling, I.
dc.contributor.authorGoldhardt, O.
dc.contributor.authorGobom, J.
dc.contributor.authorGrimmer, T.
dc.contributor.authorHaapasalo, A.
dc.contributor.authorHampel, H.
dc.contributor.authorHanon, O.
dc.contributor.authorHausner, L.
dc.contributor.authorHeilmann-Heimbach, S.
dc.contributor.authorHelisalmi, S.
dc.contributor.authorHeneka, M.T.
dc.contributor.authorHernández, I.
dc.contributor.authorHerukka, S.-K.
dc.contributor.authorHolstege, H.
dc.contributor.authorJarholm, J.
dc.contributor.authorKern, S.
dc.contributor.authorKnapskog, A.-B.
dc.contributor.authorKoivisto, A.M.
dc.contributor.authorKornhuber, J.
dc.contributor.authorKuulasmaa, T.
dc.contributor.authorLage, C.
dc.contributor.authorLaske, C.
dc.contributor.authorLeinonen, V.
dc.contributor.authorLewczuk, P.
dc.contributor.authorLleó, A.
dc.contributor.authorde Munain, A.L.
dc.contributor.authorLopez-Garcia, S.
dc.contributor.authorMaier, W.
dc.contributor.authorMarquié, M.
dc.contributor.authorMol, M.O.
dc.contributor.authorMontrreal, L.
dc.contributor.authorMoreno, F.
dc.contributor.authorMoreno-Grau, S.
dc.contributor.authorNicolas, G.
dc.contributor.authorNöthen, M.M.
dc.contributor.authorOrellana, A.
dc.contributor.authorPålhaugen, L.
dc.contributor.authorPapma, J.M.
dc.contributor.authorPasquier, F.
dc.contributor.authorPerneczky, R.
dc.contributor.authorPeters, O.
dc.contributor.authorPijnenburg, Y.A.L.
dc.contributor.authorPopp, J.
dc.contributor.authorPosthuma, D.
dc.contributor.authorPozueta, A.
dc.contributor.authorPriller, J.
dc.contributor.authorPuerta, R.
dc.contributor.authorQuintela García, Inés
dc.contributor.authorRamakers, I.
dc.contributor.authorRodriguez-Rodriguez, E.
dc.contributor.authorRujescu, D.
dc.contributor.authorSaltvedt, I.
dc.contributor.authorSanchez-Juan, P.
dc.contributor.authorScheltens, P.
dc.contributor.authorScherbaum, N.
dc.contributor.authorSchmid, M.
dc.contributor.authorSchneider, A.
dc.contributor.authorSelbæk, G.
dc.contributor.authorSelnes, P.
dc.contributor.authorShadrin, A.
dc.contributor.authorSkoog, I.
dc.contributor.authorSoininen, H.
dc.contributor.authorTárraga, L.
dc.contributor.authorTeipel, S.
dc.contributor.authorTijms, B.
dc.contributor.authorTsolaki, M.
dc.contributor.authorVan Broeckhoven, C.
dc.contributor.authorVan Dongen, J.
dc.contributor.authorvan Swieten, J.C.
dc.contributor.authorVandenberghe, R.
dc.contributor.authorVidal, J.-S.
dc.contributor.authorVisser, P.J.
dc.contributor.authorVogelgsang, J.
dc.contributor.authorWaern, M.
dc.contributor.authorWagner, M.
dc.contributor.authorWiltfang, J.
dc.contributor.authorWittens, M.M.J.
dc.contributor.authorZetterberg, H.
dc.contributor.authorZulaica, M.
dc.contributor.authorvan Duijn, C.M.
dc.contributor.authorBjerke, M.
dc.contributor.authorEngelborghs, S.
dc.contributor.authorJessen, F.
dc.contributor.authorTeunissen, C.E.
dc.contributor.authorPastor, P.
dc.contributor.authorHiltunen, M.
dc.contributor.authorIngelsson, M.
dc.contributor.authorAndreassen, O.A.
dc.contributor.authorClarimón, J.
dc.contributor.authorSleegers, K.
dc.contributor.authorRuiz, A.
dc.contributor.authorRamirez, A.
dc.contributor.authorCruchaga, C.
dc.contributor.authorLambert, J.-C.
dc.contributor.authorvan der Flier, W.
dc.date.accessioned2025-08-26T09:28:38Z
dc.date.available2025-08-26T09:28:38Z
dc.date.issued2022
dc.identifier.citationJansen IE, van der Lee SJ, Gomez-Fonseca D, de Rojas I, Dalmasso MC, Grenier-Boley B, et al. Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers. Acta Neuropathologica. 2022;144(5):821-42.
dc.identifier.issn1432-0533
dc.identifier.otherhttps://portalcientifico.sergas.gal/documentos/63389a0a250f6f2135360dd2*
dc.identifier.urihttp://hdl.handle.net/20.500.11940/20673
dc.description.abstractAmyloid-beta 42 (A?42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer's disease (AD) more directly than clinical diagnosis. Initiated by the European Alzheimer & Dementia Biobank (EADB), the largest collaborative effort on genetics underlying CSF biomarkers was established, including 31 cohorts with a total of 13,116 individuals (discovery n = 8074; replication n = 5042 individuals). Besides the APOE locus, novel associations with two other well-established AD risk loci were observed; CR1 was shown a locus for A?42 and BIN1 for pTau. GMNC and C16orf95 were further identified as loci for pTau, of which the latter is novel. Clustering methods exploring the influence of all known AD risk loci on the CSF protein levels, revealed 4 biological categories suggesting multiple A?42 and pTau related biological pathways involved in the etiology of AD. In functional follow-up analyses, GMNC and C16orf95 both associated with lateral ventricular volume, implying an overlap in genetic etiology for tau levels and brain ventricular volume.en
dc.description.sponsorshipThis work was supported by a grant (European Alzheimer DNA BioBank, EADB) from the EU Joint Programme, Neurodegenerative Disease Research (JPND). Amsterdam dementia Cohort (ADC): Research of the Alzheimer center Amsterdam is part of the neurodegeneration research program of Amsterdam Neuroscience. The Alzheimer Center Amsterdam is supported by Stichting Alzheimer Nederland and Stichting VUmc fonds. The clinical database structure was developed with funding from Stichting Dioraphte. Genotyping of the Dutch case-control samples was performed in the context of EADB (European Alzheimer DNA biobank) funded by the JPco-fuND FP-829-029 (ZonMW project number 733051061). Part of the work described in this study was carried out in the context of the Parelsnoer Institute (PSI). PSI was part of and funded by the Dutch Federation of University Medical Centers and has received initial funding from the Dutch Government (from 2007-2011). Since 2020, this work was carried out in the context of Parelsnoer clinical biobanks at Health-RI (https://www.health-ri.nl/initiatives/parelsnoer).Part of the genotyping included in this work was funded by the JPND EADB grant (German Federal Ministry of Education and Research (BMBF) grant: 01ED1619A). Alfredo Ramirez is also supported by the German Research Foundation (DFG) grants Nr: RA 1971/6-1, RA1971/7-1, and RA 1971/8-1. We would like to thank patients and controls who participated in this project. The Genome Research @ Fundacio ACE project (GR@ACE) is supported by Grifols SA, Fundacion bancaria 'La Caixa', Fundacio ACE, and CIBERNED. A.R. and M.B. receive support from the European Union/EFPIA Innovative Medicines Initiative Joint undertaking ADAPTED and MOPEAD projects (grant numbers 115975 and 115985, respectively). M.B. and A.R. are also supported by national grants PI13/02434, PI16/01861, PI17/01474, PI19/01240 and PI19/01301. Accion Estrategica en Salud is integrated into the Spanish National R + D + I Plan and funded by ISCIII (Instituto de Salud Carlos III)-Subdireccion General de Evaluacion and the Fondo Europeo de Desarrollo Regional (FEDER-'Una manera de hacer Europa'). The position held by I.dR. is funded by grant. FI20/00215. PFIS Contratos Predoctorales de Formacion en Investigacion en Salud. We would like to thank UCL Genomics, London, UK, for performing the genotyping analyses of the samples within the Gothenburg H70 Birth Cohort Studies and Clinical AD Sweden. The recruitment and clinical characterization of research participants at Washington University were supported by NIH P30AG066444, and P01AG003991. This work was supported by access to equipment made possible by the Hope Center for Neurological Disorders, the Neurogenomics and Informatics Center (NGI: https://neurogenom ics.wustl.edu/)and the Departments of Neurology and Psychiatry at Washington University School of Medicine. Research at the Belgian EADB site is funded in part by the Alzheimer Research Foundation (SAO-FRA), The Research Foundation Flanders (FWO), and the University of Antwerp Research Fund. FK is supported by a BOF DOCPRO fellowship of the University of Antwerp Research Fund. The work of Valdecilla was supported by grants from the Instituto de Salud Carlos III (Fondo de Investigacion Sanitario, PI08/0139, PI12/02288, PI16/01652, and PI20/01011), the JPND (DEMTEST PI11/03028), the CIBERNED, and the Siemens Healthineers. We thank the Valdecilla Biobank (PT17/0015/0019), integrated into the Spanish Biobank Network, for their support and collaboration in sample collection and management.Our heartfelt thanks to the participants of the Valdecilla Cohort for their generosity. The work of ADGEN was supported by EU Joint Programme-Neurodegenerative Disease Research (301220) and the Academy of Finland (338182). The DELCODE study (Study-ID:BN012) was supported and conducted by the German Center for Neurodegenerative Diseases (DZNE). The data samples were provided by the DELCODE study group. Details and participating sites can be found at www.dzne.de/en/research/studies/clinical-studies/delco de. The German Dementia Competence Network (KND) is funded by the German Federal Ministry of Education and Research (BMBF) grants Number: 01G10102, 01GI0420, 01GI0422, 01GI0423, 01GI0429, 01GI0431, 01GI0433, 04GI0434, 01GI0711. WF, SvdL, HHolstege, CT and PhS are recipients of ABOARD, which is a public-private partnership receiving funding from ZonMW (#73305095007) and HealthHolland, Topsector Life Sciences & Health (PPP-allowance; #LSHM20106). More than 30 partners participate in ABOARD (www.aboard-project.nl).ABOARD also receives funding from de Hersenstichting, Edwin Bouw Fonds and Gieskes-Strijbisfonds. IEJ was partially supported by NWO Gravitation program BRAINSCAPES: A Roadmap from Neurogenetics to Neurobiology (NWO: 024.004.012). AZ was supported by the Swedish Alzheimer Foundation (AF-939988, AF-930582, AF-646061, AF-741361), and the Dementia Foundation (2020-04-13, 2021-0417). ISk was supported by the Swedish state under the agreement between the Swedish government and the county councils, the ALFagreement (ALF 716681), the Swedish Research Council (no 11267, 825-2012-5041, 2013-8717, 2015-02830, 2017-00639, 2019-01096), Swedish Research Council for Health, Working Life and Welfare (no 2001-2646, 2001-2835, 2001-2849, 2003-0234, 2004-0150, 20050762, 2006-0020, 2008-1229, 2008-1210, 2012-1138, 2004-0145, 2006-0596, 2008-1111, 2010-0870, 2013-1202, 2013-2300, 20132496), Swedish Brain Power, Hjarnfonden, Sweden (FO2016-0214, FO2018-0214, FO2019-0163), the Alzheimer's Association Zenith Award (ZEN-01-3151), the Alzheimer's Association Stephanie B. Overstreet Scholars (IIRG-00-2159), the Alzheimer's Association (IIRG-03-6168, IIRG-09-131338) and the Bank of Sweden Tercentenary Foundation. SK was supported by the Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement (ALFGBG-81392, ALF GBG-771071), the Swedish Alzheimer Foundation (AF-842471, AF-737641, AF-939825), and the Swedish Research Council (2019-02075). MW was supported by the Swedish Research Council 2016-01590. DP was supported by BRAINSCAPES: A Roadmap from Neurogenetics to Neurobiology (grant no. 024.004.012), and a European Research Council advanced grant (Grant No, ERC-2018-AdG GWAS2FUNC 834057. HZ is a Wallenberg Scholar supported by grants from the Swedish Research Council (2018-02532), the European Research Council (681712), Swedish State Support for Clinical Research (ALFGBG-720931), the Alzheimer Drug Discovery Foundation (ADDF), USA (2018092016862), the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 860197 (MIRIADE), and the UK Dementia Research Institute at UCL.KB was supported by the Swedish Research Council (#2017-00915), the Alzheimer Drug Discovery Foundation (ADDF), USA (#RDAPB201809-2016615), the Swedish Alzheimer Foundation (#AF-742881), Hjarnfonden, Sweden (#FO2017-0243), the Swedish state under the agreement between the Swedish government and the County Councils, the ALF-agreement (#ALFGBG-715986), the European Union Joint Program for Neurodegenerative Disorders (JPND2019-466-236), the National Institute of Health (NIH), USA, (grant #1R01AG06839801), and the Alzheimer's Association 2021 Zenith Award (ZEN-21848495). CC receives support from the National Institutes of Health (R01AG044546, R01AG064877, RF1AG053303, R01AG058501, U01AG058922, RF1AG058501, R01AG064614), and the Chuck Zuckerberg Initiative (CZI).en
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleGenome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers*
dc.typeArticleen
dc.authorsophosJansen, W. I. E.
dc.authorsophosvan der Lee, S. J.
dc.authorsophosGomez-Fonseca, D.
dc.authorsophosde Rojas, I.
dc.authorsophosDalmasso, M. C.
dc.authorsophosGrenier-Boley, B.
dc.authorsophosZettergren, A.
dc.authorsophosMishra, A.
dc.authorsophosAli, M.
dc.authorsophosAndrade, V.
dc.authorsophosBellenguez, C.
dc.authorsophosKleineidam, L.
dc.authorsophosKüçükali, F.
dc.authorsophosSung, Y. J.
dc.authorsophosTesí, N.
dc.authorsophosVromen, E. M.
dc.authorsophosWightman, D. P.
dc.authorsophosAlcolea, D.
dc.authorsophosAlegret, M.
dc.authorsophosAlvarez, I.
dc.authorsophosAmouyel, P.
dc.authorsophosAthanasiu, L.
dc.authorsophosBahrami, S.
dc.authorsophosBailly, H.
dc.authorsophosBelbin, O.
dc.authorsophosBergh, S.
dc.authorsophosBertram, L.
dc.authorsophosBiessels, G. J.
dc.authorsophosBlennow, K.
dc.authorsophosBlesa, R.
dc.authorsophosBoada, M.
dc.authorsophosBoland, A.
dc.authorsophosBuerger, K.
dc.authorsophosCarracedo, Á
dc.authorsophosCervera-Carles, L.
dc.authorsophosChene, G.
dc.authorsophosClaassen, J. A. H. R.
dc.authorsophosDebette, S.
dc.authorsophosDeleuze, J. F.
dc.authorsophosde Deyn, P. P.
dc.authorsophosDiehl-Schmid, J.
dc.authorsophosDjurovic, S.
dc.authorsophosDols-Icardo, O.
dc.authorsophosDufouil, C.
dc.authorsophosDuron, E.
dc.authorsophosDüzel, E.
dc.authorsophosFladby, T.
dc.authorsophosFortea, J.
dc.authorsophosFrölich, L.
dc.authorsophosGarcía-González, P.
dc.authorsophosGarcia-Martinez, M.
dc.authorsophosGiegling, I.
dc.authorsophosGoldhardt, O.
dc.authorsophosGobom, J.
dc.authorsophosGrimmer, T.
dc.authorsophosHaapasalo, A.
dc.authorsophosHampel, H.
dc.authorsophosHanon, O.
dc.authorsophosHausner, L.
dc.authorsophosHeilmann-Heimbach, S.
dc.authorsophosHelisalmi, S.
dc.authorsophosHeneka, M. T.
dc.authorsophosHernández, I.
dc.authorsophosHerukka, S. K.
dc.authorsophosHolstege, H.
dc.authorsophosJarholm, J.
dc.authorsophosKern, S.
dc.authorsophosKnapskog, A. B.
dc.authorsophosKoivisto, A. M.
dc.authorsophosKornhuber, J.
dc.authorsophosKuulasmaa, T.
dc.authorsophosLage, C.
dc.authorsophosLaske, C.
dc.authorsophosLeinonen, V.
dc.authorsophosLewczuk, P.
dc.authorsophosLleó, A.
dc.authorsophosde Munain, A. L.
dc.authorsophosLopez-Garcia, S.
dc.authorsophosMaier, W.
dc.authorsophosMarquié, M.
dc.authorsophosMol, M. O.
dc.authorsophosMontrreal, L.
dc.authorsophosMoreno, F.
dc.authorsophosMoreno-Grau, S.
dc.authorsophosNicolas, G.
dc.authorsophosNöthen, M. M.
dc.authorsophosOrellana, A.
dc.authorsophosPålhaugen, L.
dc.authorsophosPapma, J. M.
dc.authorsophosPasquier, F.
dc.authorsophosPerneczky, R.
dc.authorsophosPeters, O.
dc.authorsophosPijnenburg, Y. A. L.
dc.authorsophosPopp, J.
dc.authorsophosPosthuma, D.
dc.authorsophosPozueta, A.
dc.authorsophosPriller, J.
dc.authorsophosPuerta, R.
dc.authorsophosQuintela, I.
dc.authorsophosRamakers, I.
dc.authorsophosRodriguez-Rodriguez, E.
dc.authorsophosRujescu, D.
dc.authorsophosSaltvedt, I.
dc.authorsophosSanchez-Juan, P.
dc.authorsophosScheltens, P.
dc.authorsophosScherbaum, N.
dc.authorsophosSchmid, M.
dc.authorsophosSchneider, A.
dc.authorsophosSelbæk, G.
dc.authorsophosSelnes, P.
dc.authorsophosShadrin, A.
dc.authorsophosSkoog, I.
dc.authorsophosSoininen, H.
dc.authorsophosTárraga, L.
dc.authorsophosTeipel, S.
dc.authorsophosTijms, B.
dc.authorsophosTsolaki, M.
dc.authorsophosVan Broeckhoven, C.
dc.authorsophosVan Dongen, J.
dc.authorsophosvan Swieten, J. C.
dc.authorsophosVandenberghe, R.
dc.authorsophosVidal, J. S.
dc.authorsophosVisser, P. J.
dc.authorsophosVogelgsang, J.
dc.authorsophosWaern, M.
dc.authorsophosWagner, M.
dc.authorsophosWiltfang, J.
dc.authorsophosWittens, M. M. J.
dc.authorsophosZetterberg, H.
dc.authorsophosZulaica, M.
dc.authorsophosvan Duijn, C. M.
dc.authorsophosBjerke, M.
dc.authorsophosEngelborghs, S.
dc.authorsophosJessen, F.
dc.authorsophosTeunissen, C. E.
dc.authorsophosPastor, P.
dc.authorsophosHiltunen, M.
dc.authorsophosIngelsson, M.
dc.authorsophosAndreassen, O. A.
dc.authorsophosClarimón, J.
dc.authorsophosSleegers, K.
dc.authorsophosRuiz, A.
dc.authorsophosRamirez, A.
dc.authorsophosCruchaga, C.
dc.authorsophosLambert, J. C.
dc.authorsophosvan der, Flier
dc.identifier.doi10.1007/s00401-022-02454-z
dc.identifier.sophos63389a0a250f6f2135360dd2
dc.issue.number5
dc.journal.titleActa Neuropathologica*
dc.page.initial821
dc.page.final842
dc.relation.projectIDEU Joint Programme, Neurodegenerative Disease Research (JPND); Stichting Alzheimer Nederland; Stichting VUmc fonds; Stichting Dioraphte; JPco-fuND (ZonMW project) [FP-829-029, 733051061]; Dutch Federation of University Medical Centers; Dutch Government; JPND EADB grant (German Federal Ministry of Education and Research (BMBF)) [01ED1619A]; German Research Foundation (DFG) [RA 1971/6-1, RA1971/7-1, RA 1971/8-1]; Grifols SA; Fundacion bancaria 'La Caixa'; Fundacio ACE; CIBERNED; European Union/EFPIA Innovative Medicines Initiative Joint undertaking ADAPTED project [115975, 115985]; European Union/EFPIA Innovative Medicines Initiative Joint undertaking MOPEAD project [115975, 115985]; ISCIII (Instituto de Salud Carlos III)-Subdireccion General de Evaluacion; Fondo Europeo de Desarrollo Regional (FEDER-'Una manera de hacer Europa'); PFIS Contratos Predoctorales de Formacion en Investigacion en Salud [FI20/00215]; NIH [P30AG066444, P01AG003991]; Hope Center for Neurological Disorders; Neurogenomics and Informatics Center; Alzheimer Research Foundation (SAO-FRA); Research Foundation Flanders (FWO); University of Antwerp Research Fund; BOF DOCPRO fellowship of the University of Antwerp Research Fund; Instituto de Salud Carlos III (Fondo de Investigacion Sanitario) [PI08/0139, PI12/02288, PI16/01652, PI20/01011]; JPND [DEMTEST PI11/03028]; Siemens Healthineers; Valdecilla Biobank [PT17/0015/0019]; EU Joint Programme-Neurodegenerative Disease Research [301220]; Academy of Finland [338182]; German Center for Neurodegenerative Diseases (DZNE); German Federal Ministry of Education and Research (BMBF) [01G10102, 01GI0420, 01GI0422, 01GI0423, 01GI0429, 01GI0431, 01GI0433, 04GI0434, 01GI0711]; ZonMW [73305095007]; HealthHolland, Topsector Life Sciences Health [LSHM20106]; Hersenstichting; Edwin Bouw Fonds; Gieskes-Strijbisfonds; NWO Gravitation program BRAINSCAPES: A Roadmap from Neurogenetics to Neurobiology [NWO: 024.004.012]; Swedish Alzheimer Foundation [AF-939988, AF-930582, AF-646061, AF-741361, AF-842471, AF-737641, AF-939825, AF-742881]; Dementia Foundation [2020-04-13, 2021-0417]; Swedish government [ALF 716681, ALFGBG-81392, ALF GBG-771071, ALFGBG-715986]; Swedish Research Council [2017-009151, 1267, 825-2012-5041, 2013-8717, 2015-02830, 2017-00639, 2019-01096, 2019-02075, 2016-01590, 2018-02532]; Swedish Research Council for Health, Working Life and Welfare [2001-2646, 2001-2835, 2001-2849, 2003-0234, 2004-0150, 20050762, 2006-0020, 2008-1229, 2008-1210, 2012-1138, 2004-0145, 2006-0596, 2008-1111, 2010-0870, 2013-1202, 2013-2300, 20132496]; Swedish Brain Power, Hjarnfonden, Sweden [FO2016-0214, FO2018-0214, FO2019-0163]; Alzheimer's Association Zenith Award [ZEN-01-3151]; Alzheimer's Association Stephanie B. Overstreet Scholars [IIRG-00-2159]; Alzheimer's Association [IIRG-03-6168, IIRG-09-131338]; Bank of Sweden Tercentenary Foundation; BRAINSCAPES: A Roadmap from Neurogenetics to Neurobiology [024.004.012]; European Research Council advanced grant [ERC-2018-AdG GWAS2FUNC 834057]; European Research Council [681712]; Swedish State Support for Clinical Research [ALFGBG-720931]; Alzheimer Drug Discovery Foundation (ADDF), USA [2018092016862]; European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie [860197]; UK Dementia Research Institute at UCL; Hjarnfonden, Sweden [FO2017-0243]; European Union Joint Program for Neurodegenerative Disorders [JPND2019-466-236]; National Institute of Health (NIH), USA [1R01AG06839801]; Alzheimer's Association 2021 Zenith Award [ZEN-21848495]; National Institutes of Health [R01AG044546, R01AG064877, RF1AG053303, R01AG058501, U01AG058922, RF1AG058501, R01AG064614]; Chuck Zuckerberg Initiative (CZI); Department of Neurology at Washington University School of Medicine; Department of Psychiatry at Washington University School of Medicine; [PI13/02434]; [PI16/01861]; [PI17/01474]; [PI19/01240]; [PI19/01301]; Academy of Finland (AKA) [301220] Funding Source: Academy of Finland (AKA); National Institute on Aging [U01AG058922] Funding Source: NIH RePORTER
dc.relation.publisherversionhttps://link.springer.com/content/pdf/10.1007%2Fs00401-022-02454-z.pdf;https://link.springer.com/content/pdf/10.1007/s00401-022-02454-z.pdfes
dc.rights.accessRightsopenAccess
dc.subject.keywordFPGMXes
dc.subject.keywordAS Santiagoes
dc.subject.keywordIDISes
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)es
dc.typesophosArtículo Originales
dc.volume.number144


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