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dc.contributor.authorFernández-Pereira, C.
dc.contributor.authorPenedo, M.A.
dc.contributor.authorRivera-Baltanas, T.
dc.contributor.authorFernández Martínez, Rafael 
dc.contributor.authorOrtolano ., Saida
dc.contributor.authorOlivares, J.M.
dc.contributor.authorAgis Balboa, Roberto Carlos 
dc.date.accessioned2025-08-26T10:51:54Z
dc.date.available2025-08-26T10:51:54Z
dc.date.issued2022
dc.identifier.citationFernández-Pereira C, Penedo MA, Rivera-Baltanas T, Fernández-Martínez R, Ortolano S, Olivares JM, et al. Insulin-like Growth Factor 2 (IGF-2) and Insulin-like Growth Factor Binding Protein 7 (IGFBP-7) Are Upregulated after Atypical Antipsychotics in Spanish Schizophrenia Patients. International Journal of Molecular Sciences. 2022;23(17).
dc.identifier.issn1422-0067
dc.identifier.otherhttps://portalcientifico.sergas.gal/documentos/63824b5e8a8e8f467220241b*
dc.identifier.urihttp://hdl.handle.net/20.500.11940/20708
dc.description.abstractInsulin-like growth factor 2 (IGF-2) and IGF binding protein 7 (IGFBP-7) have been related to schizophrenia (SZ) due to their implication in neurodevelopment. The purpose of this study was to assess whether the alterations in IGF-2 and IGFBP-7 in SZ patients are intrinsically related to the psychiatric disorder itself or are a secondary phenomenon due to antipsychotic treatment. In order to test this hypothesis, we measured plasma IGF-2 and IGFBP-7 in drug-naïve first episode (FE) and multiple episodes or chronic (ME) SZ Caucasian patients who have been following treatment for years. A total of 55 SZ patients (FE = 15, ME = 40) and 45 healthy controls were recruited. The Positive and Negative Syndrome Scale (PANSS) and the Self-Assessment Anhedonia Scale (SAAS) were employed to check schizophrenic symptomatology and anhedonia, respectively. Plasma IGF-2 and IGFBP-7 levels were measured by Enzyme-Linked Immunosorbent Assay (ELISA). The FE SZ patients had much lower IGF-2, but not IGFBP-7, than controls. Moreover, both IGF-2 and IGFBP-7 significantly increased after atypical antipsychotic treatment (aripiprazole, olanzapine, or risperidone) in these patients. On the other hand, chronic patients showed higher levels of both proteins when compared to controls. Our study suggests that circulatory IGF-2 and IGFBP-7 increase after antipsychotic treatment, regardless of long-term conditions and being lower in drug-naïve FE patients.en
dc.description.sponsorshipThe authors would like to thank Galicia Sur Health Research Institute and the area Sanitaria de Vigo for their support. We especially thank the Psychiatric Nursing Service and Psychiatrists at the alvaro Cunqueiro Hospital and Nicolas Pena Hospital.en
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleInsulin-like Growth Factor 2 (IGF-2) and Insulin-like Growth Factor Binding Protein 7 (IGFBP-7) Are Upregulated after Atypical Antipsychotics in Spanish Schizophrenia Patients*
dc.typeArticleen
dc.authorsophosFernández-Pereira, R. C. C.
dc.authorsophosPenedo, M. A.
dc.authorsophosRivera-Baltanas, T.
dc.authorsophosFernández-Martínez, R.
dc.authorsophosOrtolano, S.
dc.authorsophosOlivares, J. M.
dc.authorsophosAgís, Balboa
dc.identifier.doi10.3390/ijms23179591
dc.identifier.sophos63824b5e8a8e8f467220241b
dc.issue.number17
dc.journal.titleInternational Journal of Molecular Sciences*
dc.relation.projectIDGalicia Sur Health Research Institute
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/23/17/9591/pdf?version=1661412487;https://mdpi-res.com/d_attachment/ijms/ijms-23-09591/article_deploy/ijms-23-09591-v2.pdf?version=1661412487es
dc.rights.accessRightsopenAccess
dc.subject.keywordAS Vigoes
dc.subject.keywordCHUVIes
dc.subject.keywordIISGSes
dc.subject.keywordIDISes
dc.subject.keywordCHUSes
dc.subject.keywordAS Santiagoes
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)es
dc.typesophosArtículo Originales
dc.volume.number23


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