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ME20-S as a Potential Biomarker for the Evaluation of Uveal Melanoma
dc.contributor.author | Bande Rodriguez, Manuel Francisco | |
dc.contributor.author | Santiago Varela, Maria | |
dc.contributor.author | Mera Yáñez, Purificación | |
dc.contributor.author | Piulats, J. M. | |
dc.contributor.author | Blanco Teijeiro, María Jose | |
dc.contributor.author | Rodriguez-Alvarez, M. X. | |
dc.contributor.author | Capeáns Tomé, María del Carmen | |
dc.contributor.author | Piñeiro Ces, Antonio | |
dc.contributor.author | Pardo, M. | |
dc.date.accessioned | 2017-06-07T07:03:10Z | |
dc.date.available | 2017-06-07T07:03:10Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0146-0404 | |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/2077 | |
dc.description.abstract | PURPOSE: We previously identified the presence of the melanocyte-specific secreted (ME20-S) glycoprotein in secretomes of uveal melanoma (UM) cultures. The aim of this study was to test for the presence and levels of ME20-S in the serum of patients with choroidal nevi and UM and correlate these levels with individual clinical data. METHODS: Serum ME20-S levels were determined by ELISA in 111 patients distributed into four categories (53 choroidal nevi, 30 untreated UM, 11 10-year disease-free [DF] UM, 17 hepatic metastatic UM) and 32 age- and sex-matched controls. ME20-S levels were correlated with individual clinical data. RESULTS: The UM and the metastatic groups showed significantly higher levels of serum ME20-S than the other groups (P < 0.001). ME20-S levels in the DF patients did not differ from those in the control group. In addition, log-transformed serum ME20-S levels showed a positive correlation with the thickness of the lesion mass in UM patients (regression coefficient 0.0689, 95% confidence interval 0.0689-0.1123, R2 = 27.1%). CONCLUSIONS: Elevated ME20-S serum levels are associated with tumor size and advanced stages of UM while low levels are characteristic of DF patients. ME20-S might be a promising serum marker for UM and useful for monitoring metastatic disease. | |
dc.language.iso | eng | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Aged | |
dc.subject.mesh | Aged, 80 and over | |
dc.subject.mesh | Biomarkers, Tumor | |
dc.subject.mesh | Disease Progression | |
dc.subject.mesh | Enzyme-Linked Immunosorbent Assay | |
dc.subject.mesh | Female | |
dc.subject.mesh | Follow-Up Studies | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Male | |
dc.subject.mesh | Melanoma | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Retrospective Studies | |
dc.subject.mesh | Uveal Neoplasms | |
dc.subject.mesh | Young Adult | |
dc.subject.mesh | gp100 Melanoma Antigen | |
dc.title | ME20-S as a Potential Biomarker for the Evaluation of Uveal Melanoma | |
dc.type | Artigo | es |
dc.authorsophos | Bande, M. F. | |
dc.authorsophos | Santiago, M. | |
dc.authorsophos | Mera, P. | |
dc.authorsophos | Piulats, J. M. | |
dc.authorsophos | Blanco, M. J. | |
dc.authorsophos | Rodriguez-Alvarez, M. X. | |
dc.authorsophos | Capeans, C. | |
dc.authorsophos | Pineiro, A. | |
dc.authorsophos | Pardo, M. | |
dc.identifier.doi | 10.1167/iovs.15-17183 | |
dc.identifier.isi | 368238200001 | |
dc.identifier.pmid | 26523384 | |
dc.identifier.sophos | 18571 | |
dc.issue.number | 12 | |
dc.journal.title | INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago - Complexo Hospitalario Universitario de Santiago::Oftalmoloxía | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago | |
dc.page.initial | 7007 | |
dc.page.final | 11 | |
dc.rights.accessRights | openAccess | |
dc.subject.decs | Adulto | |
dc.subject.decs | Adulto Joven | |
dc.subject.decs | Anciano | |
dc.subject.decs | Anciano de 80 o más Años | |
dc.subject.decs | Antígeno gp100 del Melanoma | |
dc.subject.decs | Biomarcadores de Tumor | |
dc.subject.decs | Ensayo de Inmunoadsorción Enzimática | |
dc.subject.decs | Estudios Retrospectivos | |
dc.subject.decs | Estudios de Seguimiento | |
dc.subject.decs | Femenino | |
dc.subject.decs | Melanoma | |
dc.subject.decs | Neoplasias de la Úvea | |
dc.subject.decs | Persona de Mediana Edad | |
dc.subject.decs | Progresión de la Enfermedad | |
dc.typesophos | Artículo Original | |
dc.volume.number | 56 |