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dc.contributor.authorRibeiro, L.
dc.contributor.authorMarques, I.P.
dc.contributor.authorCoimbra, R.
dc.contributor.authorSantos, T.
dc.contributor.authorMadeira, M.H.
dc.contributor.authorSantos Simoes, Ana Rita
dc.contributor.authorBarreto, P.
dc.contributor.authorLobo, C.
dc.contributor.authorCunha-Vaz, J.
dc.date.accessioned2025-08-26T11:02:18Z
dc.date.available2025-08-26T11:02:18Z
dc.date.issued2022
dc.identifier.citationRibeiro L, Marques IP, Coimbra R, Santos T, Madeira MH, Santos AR, et al. Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy. Ophthalmology and Therapy. 2022;11(1):333-45.
dc.identifier.issn2193-6528
dc.identifier.otherhttps://portalcientifico.sergas.gal/documentos/6416a4de5db420433b7b5fc8*
dc.identifier.urihttp://hdl.handle.net/20.500.11940/20824
dc.description.abstractIntroduction: We characterized the progression of different diabetic retinopathy (DR) phenotypes in type 2 diabetes (T2D). Methods: A prospective longitudinal cohort study (CORDIS, NCT03696810) was conducted with three visits (baseline, 6 months, and 1 year). Demographic and systemic data included age, sex, diabetes duration, lipid profile, and hemoglobin A1c (HbA1c). Ophthalmological examinations included best-corrected visual acuity (BCVA), color fundus photography (CFP), and optical coherence tomography (OCT and OCTA). Phenotype classification was performed at the 6-month visit based on microaneurysm turnover (MAT, on CFP) and central retinal thickness (CRT, on OCT). Only risk phenotypes B (MAT < 6 and increased CRT) and C (MAT ? 6 with or without increased CRT) were included. ETDRS grading was performed at the baseline visit based on seven-field CFP. Results: A total of 133 T2D individuals were included in the study; 81 (60%) eyes were classified as phenotype B and 52 (40%) eyes as phenotype C. Of these, 128 completed the 1-year follow-up. At baseline, eyes with phenotype C showed greater capillary closure (superior capillary plexus, deep capillary plexus, and full retina, p < 0.001) and increased foveal avascular zone (FAZ) area (p < 0.001), indicating more advanced microvascular disease. Neurodegeneration represented by thinning of the ganglion cell layer + inner plexiform layer (GCL + IPL) was present in both phenotypes. When analyzing the 1-year progression of each phenotype, only phenotype C revealed a significant decrease in BCVA (p = 0.02) and enlargement of the FAZ (p = 0.03). A significant progressive decrease in the vessel density of the deep capillary layer and in MAT occurred in both phenotypes, but these changes were particularly relevant in phenotype C and ETDRS grades 43-47. During the 1-year period, both phenotypes B and C showed progression in GCL + IPL thinning (p < 0.001). Conclusions: In the 1-year period of follow-up, both phenotypes B and C showed progression in retinal neurodegeneration, whereas phenotype C showed more marked disease progression at the microvascular level.en
dc.description.sponsorshipThis work was supported by AIBILI, COMPETE Portugal2020, Foundation for Science and Technology (Project no: 02/SAICT/2017-032412) and the Fundo de Inovacao, Tecnologia e Economia Circular (FITEC)-Programa Interface (FITEC/CIT/2018/2). No funding or sponsorship was received for publication of this article.en
dc.language.isoeng
dc.rightsAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.titleCharacterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy*
dc.typeArticleen
dc.authorsophosRibeiro, J. L.
dc.authorsophosMarques, I. P.
dc.authorsophosCoimbra, R.
dc.authorsophosSantos, T.
dc.authorsophosMadeira, M. H.
dc.authorsophosSantos, A. R.
dc.authorsophosBarreto, P.
dc.authorsophosLobo, C.
dc.authorsophosCunha, Vaz
dc.identifier.doi10.1007/s40123-021-00437-z
dc.identifier.sophos6416a4de5db420433b7b5fc8
dc.issue.number1
dc.journal.titleOphthalmology and Therapy*
dc.page.initial333
dc.page.final345
dc.relation.projectIDAIBILI, COMPETE Portugal2020, Foundation for Science and Technology [02/SAICT/2017-032412]; Fundo de Inovacao, Tecnologia e Economia Circular (FITEC)-Programa Interface [FITEC/CIT/2018/2]
dc.relation.publisherversionhttps://link.springer.com/content/pdf/10.1007%2Fs40123-021-00437-z.pdf;https://link.springer.com/content/pdf/10.1007/s40123-021-00437-z.pdfes
dc.rights.accessRightsopenAccess
dc.subject.keywordAS Santiagoes
dc.subject.keywordIDISes
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)es
dc.typesophosArtículo Originales
dc.volume.number11


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