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Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy
dc.contributor.author | Ribeiro, L. | |
dc.contributor.author | Marques, I.P. | |
dc.contributor.author | Coimbra, R. | |
dc.contributor.author | Santos, T. | |
dc.contributor.author | Madeira, M.H. | |
dc.contributor.author | Santos Simoes, Ana Rita | |
dc.contributor.author | Barreto, P. | |
dc.contributor.author | Lobo, C. | |
dc.contributor.author | Cunha-Vaz, J. | |
dc.date.accessioned | 2025-08-26T11:02:18Z | |
dc.date.available | 2025-08-26T11:02:18Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Ribeiro L, Marques IP, Coimbra R, Santos T, Madeira MH, Santos AR, et al. Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy. Ophthalmology and Therapy. 2022;11(1):333-45. | |
dc.identifier.issn | 2193-6528 | |
dc.identifier.other | https://portalcientifico.sergas.gal/documentos/6416a4de5db420433b7b5fc8 | * |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/20824 | |
dc.description.abstract | Introduction: We characterized the progression of different diabetic retinopathy (DR) phenotypes in type 2 diabetes (T2D). Methods: A prospective longitudinal cohort study (CORDIS, NCT03696810) was conducted with three visits (baseline, 6 months, and 1 year). Demographic and systemic data included age, sex, diabetes duration, lipid profile, and hemoglobin A1c (HbA1c). Ophthalmological examinations included best-corrected visual acuity (BCVA), color fundus photography (CFP), and optical coherence tomography (OCT and OCTA). Phenotype classification was performed at the 6-month visit based on microaneurysm turnover (MAT, on CFP) and central retinal thickness (CRT, on OCT). Only risk phenotypes B (MAT < 6 and increased CRT) and C (MAT ? 6 with or without increased CRT) were included. ETDRS grading was performed at the baseline visit based on seven-field CFP. Results: A total of 133 T2D individuals were included in the study; 81 (60%) eyes were classified as phenotype B and 52 (40%) eyes as phenotype C. Of these, 128 completed the 1-year follow-up. At baseline, eyes with phenotype C showed greater capillary closure (superior capillary plexus, deep capillary plexus, and full retina, p < 0.001) and increased foveal avascular zone (FAZ) area (p < 0.001), indicating more advanced microvascular disease. Neurodegeneration represented by thinning of the ganglion cell layer + inner plexiform layer (GCL + IPL) was present in both phenotypes. When analyzing the 1-year progression of each phenotype, only phenotype C revealed a significant decrease in BCVA (p = 0.02) and enlargement of the FAZ (p = 0.03). A significant progressive decrease in the vessel density of the deep capillary layer and in MAT occurred in both phenotypes, but these changes were particularly relevant in phenotype C and ETDRS grades 43-47. During the 1-year period, both phenotypes B and C showed progression in GCL + IPL thinning (p < 0.001). Conclusions: In the 1-year period of follow-up, both phenotypes B and C showed progression in retinal neurodegeneration, whereas phenotype C showed more marked disease progression at the microvascular level. | en |
dc.description.sponsorship | This work was supported by AIBILI, COMPETE Portugal2020, Foundation for Science and Technology (Project no: 02/SAICT/2017-032412) and the Fundo de Inovacao, Tecnologia e Economia Circular (FITEC)-Programa Interface (FITEC/CIT/2018/2). No funding or sponsorship was received for publication of this article. | en |
dc.language.iso | eng | |
dc.rights | Atribución-NoComercial 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | Characterization of One-Year Progression of Risk Phenotypes of Diabetic Retinopathy | * |
dc.type | Article | en |
dc.authorsophos | Ribeiro, J. L. | |
dc.authorsophos | Marques, I. P. | |
dc.authorsophos | Coimbra, R. | |
dc.authorsophos | Santos, T. | |
dc.authorsophos | Madeira, M. H. | |
dc.authorsophos | Santos, A. R. | |
dc.authorsophos | Barreto, P. | |
dc.authorsophos | Lobo, C. | |
dc.authorsophos | Cunha, Vaz | |
dc.identifier.doi | 10.1007/s40123-021-00437-z | |
dc.identifier.sophos | 6416a4de5db420433b7b5fc8 | |
dc.issue.number | 1 | |
dc.journal.title | Ophthalmology and Therapy | * |
dc.page.initial | 333 | |
dc.page.final | 345 | |
dc.relation.projectID | AIBILI, COMPETE Portugal2020, Foundation for Science and Technology [02/SAICT/2017-032412]; Fundo de Inovacao, Tecnologia e Economia Circular (FITEC)-Programa Interface [FITEC/CIT/2018/2] | |
dc.relation.publisherversion | https://link.springer.com/content/pdf/10.1007%2Fs40123-021-00437-z.pdf;https://link.springer.com/content/pdf/10.1007/s40123-021-00437-z.pdf | es |
dc.rights.accessRights | openAccess | |
dc.subject.keyword | AS Santiago | es |
dc.subject.keyword | IDIS | es |
dc.typefides | Artículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis) | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 11 |
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