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dc.contributor.authorSantos, T.
dc.contributor.authorWarren, L.H.
dc.contributor.authorSantos Simoes, Ana Rita
dc.contributor.authorMarques, I.P.
dc.contributor.authorKubach, S.
dc.contributor.authorMendes, L.G.
dc.contributor.authorde Sisternes, L.
dc.contributor.authorMadeira, M.H.
dc.contributor.authorDurbin, M.
dc.contributor.authorCunha-Vaz, J.G.
dc.date.accessioned2025-08-26T11:02:21Z
dc.date.available2025-08-26T11:02:21Z
dc.date.issued2022
dc.identifier.citationSantos T, Warren LH, Santos AR, Marques IP, Kubach S, Mendes LG, et al. Swept-source OCTA quantification of capillary closure predicts ETDRS severity staging of NPDR. British Journal of Ophthalmology. 2022;106(5):712-8.
dc.identifier.issn1468-2079
dc.identifier.otherhttps://portalcientifico.sergas.gal/documentos/6416a4e05db420433b7b5fe0*
dc.identifier.urihttp://hdl.handle.net/20.500.11940/20825
dc.description.abstractPurpose To test whether a single or composite set of parameters evaluated with optical coherence tomography angiography (OCTA), representing retinal capillary closure, can predict non-proliferative diabetic retinopathy (NPDR) staging according to the gold standard ETDRS grading scheme. Methods 105 patients with diabetes, either without retinopathy or with different degrees of retinopathy (NPDR up to ETDRS grade 53), were prospectively evaluated using swept-source OCTA (SS-OCTA, PlexElite, Carl Zeiss Meditec) with 15×9 mm and 3×3 mm angiography protocols. Seven-field photographs of the fundus were obtained for ETDRS staging. Eyes from age-matched healthy subjects were also imaged as control. Results In eyes of patients with type 2 diabetes without retinopathy or ETDRS levels 20 and 35, retinal capillary closure was in the macular area, with predominant alterations in the parafoveal retinal circulation (inner ring). Retinal capillary closure in ETDRS stages 43-53 becomes predominant in the retinal midperiphery with vessel density average values of 25.2±7.9 (p=0.001) in ETDRS 43 and 23.5±3.4 (p=0.001) in ETDRS 47-53, when evaluating extended areas of 15×9 protocol. Combination of acquisition protocols 3×3 mm and 15×9 mm, using SS-OCTA, allows discrimination between eyes with mild NPDR (ETDRS 10, 20, 35) and eyes with moderate-to-severe NPDR (ETDRS grades 43-53). Conclusions Retinal capillary closure, quantified by SS-OCTA, can identify NPDR severity progression. It is located mainly in the perifoveal retinal capillary circulation in the initial stages of NPDR, whereas the retinal midperiphery is predominantly affected in moderate-to-severe NPDR.en
dc.description.sponsorshipThis work was supported by AIBILI and by COMPETE Portugal2020 and by Fundo de Inovacao, Tecnologia e Economia Circular (FITEC) -Programa Interface (FITEC/CIT/2018/2).en
dc.language.isoeng
dc.rightsAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.titleSwept-source OCTA quantification of capillary closure predicts ETDRS severity staging of NPDR*
dc.typeArticleen
dc.authorsophosSantos, J. G. T.
dc.authorsophosWarren, L. H.
dc.authorsophosSantos, A. R.
dc.authorsophosMarques, I. P.
dc.authorsophosKubach, S.
dc.authorsophosMendes, L. G.
dc.authorsophosde Sisternes, L.
dc.authorsophosMadeira, M. H.
dc.authorsophosDurbin, M.
dc.authorsophosCunha, Vaz
dc.identifier.doi10.1136/bjophthalmol-2020-317890
dc.identifier.sophos6416a4e05db420433b7b5fe0
dc.issue.number5
dc.journal.titleBritish Journal of Ophthalmology*
dc.page.initial712
dc.page.final718
dc.relation.projectIDAIBILI; COMPETE Portugal2020; Fundo de Inovacao, Tecnologia e Economia Circular (FITEC) -Programa Interface [FITEC/CIT/2018/2]
dc.relation.publisherversionhttps://bjo.bmj.com/content/bjophthalmol/106/5/712.full.pdfes
dc.rights.accessRightsopenAccess
dc.subject.keywordAS Santiagoes
dc.subject.keywordIDISes
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)es
dc.typesophosArtículo Originales
dc.volume.number106


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