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Protein Degradation by E3 Ubiquitin Ligases in Cancer Stem Cells

dc.contributor.authorQuiroga Fernández, Macarena
dc.contributor.authorRodríguez Alonso, Andrea
dc.contributor.authorAlfonsín Rey, María Gloria
dc.contributor.authorEscuder Rodríguez, Juan José
dc.contributor.authorBreijo, S.M.
dc.contributor.authorChantada, V.
dc.contributor.authorFigueroa Conde-Valvís, Angélica
dc.date.accessioned2025-08-26T11:03:08Z
dc.date.available2025-08-26T11:03:08Z
dc.date.issued2022
dc.identifier.citationQuiroga M, Rodríguez-Alonso A, Alfonsín G, Rodríguez JJE, Breijo SM, Chantada V, et al. Protein Degradation by E3 Ubiquitin Ligases in Cancer Stem Cells. Cancers. 2022;14(4).
dc.identifier.issn2072-6694
dc.identifier.otherhttps://portalcientifico.sergas.gal/documentos/6444ed9048c3090deaa25a33*
dc.identifier.urihttp://hdl.handle.net/20.500.11940/20837
dc.description.abstractCancer stem cells are a small subpopulation within the tumor with high capacity for self-renewal, differentiation and reconstitution of tumor heterogeneity. Cancer stem cells are major contributors of tumor initiation, metastasis and therapy resistance in cancer. Emerging evidence indicates that ubiquitination-mediated post-translational modification plays a fundamental role in the maintenance of cancer stem cell characteristics. In this review, we will discuss how protein degradation controlled by the E3 ubiquitin ligases plays a fundamental role in the self-renewal, maintenance and differentiation of cancer stem cells, highlighting the possibility to develop novel therapeutic strategies against E3 ubiquitin ligases targeting CSCs to fight cancer.en
dc.description.sponsorshipThis work has been supported by Plan Estatal I + D + I 2013 2016, co-funded by the Instituto de Salud Carlos III (ISCIII, Spain) under grant agreements (PI18/00121 and PI21/00238) by Fondo Europeo de Desarrollo Regional (FEDER) A way of Making Europe. The project that gave rise to these results has received funding from la Caixa Foundation and the European Institute of Innovation and Technology, EIT (body of the European Union that receives support from the European Union's Horizon 2020 research and innovation program), under the grant agreements LCF/TR/CI19/52460016 and LCF/TR/CC21/52490003. Additionally, this work was supported by the Consolidation of Competitive Research (IN607B2020/14) from GAIN from the Xunta de Galicia. M.Q. was supported by the Consolidation of Competitive Research (IN607B2020/14) from GAIN, Xunta de Galicia and A.R. was supported by a predoctoral contract (PRDLC21591RODR) from Fundacion Cientifica AECC/AECC. Alfonsin has been supported by the Instituto de Salud Carlos III (ISCIII, Spain) under grant agreements (PI18/00121).en
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleProtein Degradation by E3 Ubiquitin Ligases in Cancer Stem Cells*
dc.typeArticleen
dc.authorsophosQuiroga, A. M.
dc.authorsophosRodríguez-Alonso, A.
dc.authorsophosAlfonsín, G.
dc.authorsophosRodríguez, J. J. E.
dc.authorsophosBreijo, S. M.
dc.authorsophosChantada, V.
dc.authorsophosFigueroa
dc.identifier.doi10.3390/cancers14040990
dc.identifier.sophos6444ed9048c3090deaa25a33
dc.issue.number4
dc.journal.titleCancers*
dc.relation.projectIDPlan Estatal I + D + I - Instituto de Salud Carlos III (ISCIII, Spain) [PI18/00121, PI21/00238]; Fondo Europeo de Desarrollo Regional (FEDER); la Caixa Foundation; European Institute of Innovation and Technology, EIT (body of the European Union); (European Union's Horizon 2020 research and innovation program) [LCF/TR/CI19/52460016, LCF/TR/CC21/52490003]; Consolidation of Competitive Research [IN607B2020/14]; Xunta de Galicia [PRDLC21591RODR]; Fundacion Cientifica AECC/AECC; Instituto de Salud Carlos III (ISCIII, Spain) [PI18/00121]
dc.relation.publisherversionhttps://ruc.udc.es/dspace/bitstream/2183/30683/3/Quiroga_Protein.pdf;https://mdpi-res.com/d_attachment/cancers/cancers-14-00990/article_deploy/cancers-14-00990.pdf?version=1645000761es
dc.rights.accessRightsopenAccess
dc.subject.keywordINIBICes
dc.subject.keywordAS Coruñaes
dc.subject.keywordCHUACes
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)es
dc.typesophosArtículo Originales
dc.volume.number14


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