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Improving empiric antibiotic prescribing in pediatric bloodstream infections: a potential application of weighted-incidence syndromic combination antibiograms (WISCA)
dc.contributor.author | Cook, A. | |
dc.contributor.author | Sharland, M. | |
dc.contributor.author | Yau, Y. | |
dc.contributor.author | Bielicki, J. | |
dc.contributor.author | Grimwood, K. | |
dc.contributor.author | Cross, J. | |
dc.contributor.author | Cheung, K. | |
dc.contributor.author | Parbhoo, D. | |
dc.contributor.author | Henriques Teixeira, C. | |
dc.contributor.author | Berezin, E.N. | |
dc.contributor.author | Barreto da Silva, C. | |
dc.contributor.author | Ales Leal, I. | |
dc.contributor.author | Vieira Souza, C. | |
dc.contributor.author | Carvalheiro, C.G. | |
dc.contributor.author | de Souza, C.B.S. | |
dc.contributor.author | Turner, P. | |
dc.contributor.author | Miliya, T. | |
dc.contributor.author | Wu, L. | |
dc.contributor.author | Jin, P. | |
dc.contributor.author | Deng, J. | |
dc.contributor.author | Wang, H. | |
dc.contributor.author | Feng, J. | |
dc.contributor.author | Chen, Y. | |
dc.contributor.author | Jürna, M. | |
dc.contributor.author | Lutsar, I. | |
dc.contributor.author | Kõljalg, S. | |
dc.contributor.author | Kirjavainen, V. | |
dc.contributor.author | Kekomäki, S. | |
dc.contributor.author | Darboe, S. | |
dc.contributor.author | Okomo, U.A. | |
dc.contributor.author | Ricardo Araujo da Silva, A. | |
dc.contributor.author | Hübner, J. | |
dc.contributor.author | Christner, M. | |
dc.contributor.author | Schulze-Sturm, U. | |
dc.contributor.author | Hufnagel, M. | |
dc.contributor.author | Bluemel, B. | |
dc.contributor.author | Dimopoulou, D. | |
dc.contributor.author | Papaevangelou, V. | |
dc.contributor.author | Gkentzi, D. | |
dc.contributor.author | Kolonitsiou, F. | |
dc.contributor.author | Maraki, S. | |
dc.contributor.author | Vergadi, E. | |
dc.contributor.author | Singh, S. | |
dc.contributor.author | George, A. | |
dc.contributor.author | Dharmapalan, D. | |
dc.contributor.author | Rai, R. | |
dc.contributor.author | Shetty, K. | |
dc.contributor.author | Yewale, V. | |
dc.contributor.author | Iyer, R.N. | |
dc.contributor.author | Alvarez-Uria, G. | |
dc.contributor.author | Jinka, D.R. | |
dc.contributor.author | Ashkenazi-Hoffnung, L. | |
dc.contributor.author | Ben-Zvi, H. | |
dc.contributor.author | de Luca, M. | |
dc.contributor.author | Bernaschi, P. | |
dc.contributor.author | Pansa, P. | |
dc.contributor.author | Bianchini, S. | |
dc.contributor.author | Esposito, S. | |
dc.contributor.author | Horikoshi, Y. | |
dc.contributor.author | Higuchi, H. | |
dc.contributor.author | Castellanos-Cruz, M.D.C. | |
dc.contributor.author | Pichardo-Villalon, L. | |
dc.contributor.author | Gowin, E. | |
dc.contributor.author | Pirumova, R. | |
dc.contributor.author | Chan, S.M. | |
dc.contributor.author | Chew, K.L. | |
dc.contributor.author | Nana, T. | |
dc.contributor.author | Bandini, R. | |
dc.contributor.author | Dramowski, A. | |
dc.contributor.author | Whitelaw, A. | |
dc.contributor.author | Manzanares, A. | |
dc.contributor.author | Orellana, M.Á. | |
dc.contributor.author | Martinón Torres, Federico | |
dc.contributor.author | Dacosta Urbieta, A.I. | |
dc.contributor.author | Olson, L. | |
dc.contributor.author | Larsson, M. | |
dc.contributor.author | Preedisripipat, K. | |
dc.contributor.author | Cressey, T.R. | |
dc.contributor.author | Anugulruengkitt, S. | |
dc.contributor.author | Chatsuwan, T. | |
dc.contributor.author | Lochindarat, S. | |
dc.contributor.author | Mutitanon, S. | |
dc.contributor.author | Ssengooba, W. | |
dc.contributor.author | Tasimwa, H.B. | |
dc.contributor.author | Musoke, P. | |
dc.contributor.author | Shaw, F. | |
dc.contributor.author | Riordan, A. | |
dc.contributor.author | Fidler, K. | |
dc.contributor.author | Schilling, W. | |
dc.contributor.author | Hatcher, J. | |
dc.contributor.author | Bamford, A. | |
dc.contributor.author | McMaster, P. | |
dc.contributor.author | Harkensee, C. | |
dc.contributor.author | Moore, J. | |
dc.contributor.author | Speirs, L. | |
dc.contributor.author | Moriarty, P. | |
dc.contributor.author | Chesshyre, E. | |
dc.contributor.author | Auckland, C. | |
dc.contributor.author | Hindocha, A. | |
dc.contributor.author | Ashcroft, P. | |
dc.contributor.author | Thompson, S. | |
dc.contributor.author | Patel, S. | |
dc.contributor.author | Browning, D. | |
dc.contributor.author | Tran Minh, D. | |
dc.contributor.author | Hoang Thi Bich, N. | |
dc.date.accessioned | 2025-08-26T11:09:48Z | |
dc.date.available | 2025-08-26T11:09:48Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Cook A, Sharland M, Yau Y, Bielicki J, Grimwood K, Cross J, et al. Improving empiric antibiotic prescribing in pediatric bloodstream infections: a potential application of weighted-incidence syndromic combination antibiograms (WISCA). Expert Review of Anti-Infective Therapy. 2022;20(3):445-56. | |
dc.identifier.issn | 1744-8336 | |
dc.identifier.other | https://portalcientifico.sergas.gal/documentos/65e4228c795b6b1f94c9a527 | * |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/20866 | |
dc.description.abstract | Background: Increasing antibiotic resistance to WHO-recommended first- and second-line treatments of pediatric sepsis requires adaptation of prescribing guidelines. We discuss the potential and limitations of a weighted-incidence syndromic combination antibiogram (WISCA) as a practical tool for incorporating local microbiology data when assessing empiric coverage of commonly used antibiotics. Research design and methods: A brief questionnaire of 18 clinically significant isolates from pediatric blood cultures (Jan-Dec 2018) was sent to a global network of pediatric hospitals in July 2019. Weighted coverage estimates of non-antipseudomonal third-generation cephalosporins (3GC) and meropenem were estimated using Monte-Carlo simulation for each site reporting >100 isolates. Results: 52 hospitals in 23 countries in 5 WHO regions responded to the questionnaire; 13 sites met the sample size requirement. The most common isolates were S. aureus, Klebsiella spp., E. coli and Enterococcus spp. Coverage of 3GC ranged from 39% [95%CrI: 34-43%] to 73% (two sites: [95%CrI: 65-80%]; [95%CrI: 68-86%]) and meropenem coverage ranged from 54% [95%CrI: 47-60%] to 88% [95%CrI:84-91%]. Conclusions: A WISCA is a data-driven, clinically intuitive tool that can be used to compare empiric antibiotic regimens for pediatric sepsis using existing large datasets. The estimates can be further refined using more complex meta-analytical methods and patient characteristics. | en |
dc.language.iso | eng | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Improving empiric antibiotic prescribing in pediatric bloodstream infections: a potential application of weighted-incidence syndromic combination antibiograms (WISCA) | * |
dc.type | Article | en |
dc.authorsophos | Cook, N. A. | |
dc.authorsophos | Sharland, M. | |
dc.authorsophos | Yau, Y. | |
dc.authorsophos | Bielicki, J. | |
dc.authorsophos | Grimwood, K. | |
dc.authorsophos | Cross, J. | |
dc.authorsophos | Cheung, K. | |
dc.authorsophos | Parbhoo, D. | |
dc.authorsophos | Henriques Teixeira, C. | |
dc.authorsophos | Berezin, E. N. | |
dc.authorsophos | Barreto da Silva, C. | |
dc.authorsophos | Ales Leal, I. | |
dc.authorsophos | Vieira Souza, C. | |
dc.authorsophos | Carvalheiro, C. G. | |
dc.authorsophos | de Souza, C. B. S. | |
dc.authorsophos | Turner, P. | |
dc.authorsophos | Miliya, T. | |
dc.authorsophos | Wu, L. | |
dc.authorsophos | Jin, P. | |
dc.authorsophos | Deng, J. | |
dc.authorsophos | Wang, H. | |
dc.authorsophos | Feng, J. | |
dc.authorsophos | Chen, Y. | |
dc.authorsophos | Jürna, M. | |
dc.authorsophos | Lutsar, I. | |
dc.authorsophos | Kõljalg, S. | |
dc.authorsophos | Kirjavainen, V. | |
dc.authorsophos | Kekomäki, S. | |
dc.authorsophos | Darboe, S. | |
dc.authorsophos | Okomo, U. A. | |
dc.authorsophos | Ricardo Araujo da Silva, A. | |
dc.authorsophos | Hübner, J. | |
dc.authorsophos | Christner, M. | |
dc.authorsophos | Schulze-Sturm, U. | |
dc.authorsophos | Hufnagel, M. | |
dc.authorsophos | Bluemel, B. | |
dc.authorsophos | Dimopoulou, D. | |
dc.authorsophos | Papaevangelou, V. | |
dc.authorsophos | Gkentzi, D. | |
dc.authorsophos | Kolonitsiou, F. | |
dc.authorsophos | Maraki, S. | |
dc.authorsophos | Vergadi, E. | |
dc.authorsophos | Singh, S. | |
dc.authorsophos | George, A. | |
dc.authorsophos | Dharmapalan, D. | |
dc.authorsophos | Rai, R. | |
dc.authorsophos | Shetty, K. | |
dc.authorsophos | Yewale, V. | |
dc.authorsophos | Iyer, R. N. | |
dc.authorsophos | Alvarez-Uria, G. | |
dc.authorsophos | Jinka, D. R. | |
dc.authorsophos | Ashkenazi-Hoffnung, L. | |
dc.authorsophos | Ben-Zvi, H. | |
dc.authorsophos | de Luca, M. | |
dc.authorsophos | Bernaschi, P. | |
dc.authorsophos | Pansa, P. | |
dc.authorsophos | Bianchini, S. | |
dc.authorsophos | Esposito, S. | |
dc.authorsophos | Horikoshi, Y. | |
dc.authorsophos | Higuchi, H. | |
dc.authorsophos | Castellanos-Cruz, M. D. C. | |
dc.authorsophos | Pichardo-Villalon, L. | |
dc.authorsophos | Gowin, E. | |
dc.authorsophos | Pirumova, R. | |
dc.authorsophos | Chan, S. M. | |
dc.authorsophos | Chew, K. L. | |
dc.authorsophos | Nana, T. | |
dc.authorsophos | Bandini, R. | |
dc.authorsophos | Dramowski, A. | |
dc.authorsophos | Whitelaw, A. | |
dc.authorsophos | Manzanares, A. | |
dc.authorsophos | Orellana, M. Á | |
dc.authorsophos | Martinon-Torres, F. | |
dc.authorsophos | Dacosta Urbieta, A. I. | |
dc.authorsophos | Olson, L. | |
dc.authorsophos | Larsson, M. | |
dc.authorsophos | Preedisripipat, K. | |
dc.authorsophos | Cressey, T. R. | |
dc.authorsophos | Anugulruengkitt, S. | |
dc.authorsophos | Chatsuwan, T. | |
dc.authorsophos | Lochindarat, S. | |
dc.authorsophos | Mutitanon, S. | |
dc.authorsophos | Ssengooba, W. | |
dc.authorsophos | Tasimwa, H. B. | |
dc.authorsophos | Musoke, P. | |
dc.authorsophos | Shaw, F. | |
dc.authorsophos | Riordan, A. | |
dc.authorsophos | Fidler, K. | |
dc.authorsophos | Schilling, W. | |
dc.authorsophos | Hatcher, J. | |
dc.authorsophos | Bamford, A. | |
dc.authorsophos | McMaster, P. | |
dc.authorsophos | Harkensee, C. | |
dc.authorsophos | Moore, J. | |
dc.authorsophos | Speirs, L. | |
dc.authorsophos | Moriarty, P. | |
dc.authorsophos | Chesshyre, E. | |
dc.authorsophos | Auckland, C. | |
dc.authorsophos | Hindocha, A. | |
dc.authorsophos | Ashcroft, P. | |
dc.authorsophos | Thompson, S. | |
dc.authorsophos | Patel, S. | |
dc.authorsophos | Browning, D. | |
dc.authorsophos | Tran Minh, D. | |
dc.authorsophos | Hoang Thi, Bich | |
dc.identifier.doi | 10.1080/14787210.2021.1967145 | |
dc.identifier.sophos | 65e4228c795b6b1f94c9a527 | |
dc.issue.number | 3 | |
dc.journal.title | Expert Review of Anti-Infective Therapy | * |
dc.page.initial | 445 | |
dc.page.final | 456 | |
dc.relation.publisherversion | https://www.tandfonline.com/doi/pdf/10.1080/14787210.2021.1967145 | es |
dc.rights.accessRights | openAccess | |
dc.subject.keyword | AS Santiago | es |
dc.subject.keyword | CHUS | es |
dc.subject.keyword | IDIS | es |
dc.typefides | Artículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis) | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 20 |
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