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dc.contributor.authorCook, A.
dc.contributor.authorSharland, M.
dc.contributor.authorYau, Y.
dc.contributor.authorBielicki, J.
dc.contributor.authorGrimwood, K.
dc.contributor.authorCross, J.
dc.contributor.authorCheung, K.
dc.contributor.authorParbhoo, D.
dc.contributor.authorHenriques Teixeira, C.
dc.contributor.authorBerezin, E.N.
dc.contributor.authorBarreto da Silva, C.
dc.contributor.authorAles Leal, I.
dc.contributor.authorVieira Souza, C.
dc.contributor.authorCarvalheiro, C.G.
dc.contributor.authorde Souza, C.B.S.
dc.contributor.authorTurner, P.
dc.contributor.authorMiliya, T.
dc.contributor.authorWu, L.
dc.contributor.authorJin, P.
dc.contributor.authorDeng, J.
dc.contributor.authorWang, H.
dc.contributor.authorFeng, J.
dc.contributor.authorChen, Y.
dc.contributor.authorJürna, M.
dc.contributor.authorLutsar, I.
dc.contributor.authorKõljalg, S.
dc.contributor.authorKirjavainen, V.
dc.contributor.authorKekomäki, S.
dc.contributor.authorDarboe, S.
dc.contributor.authorOkomo, U.A.
dc.contributor.authorRicardo Araujo da Silva, A.
dc.contributor.authorHübner, J.
dc.contributor.authorChristner, M.
dc.contributor.authorSchulze-Sturm, U.
dc.contributor.authorHufnagel, M.
dc.contributor.authorBluemel, B.
dc.contributor.authorDimopoulou, D.
dc.contributor.authorPapaevangelou, V.
dc.contributor.authorGkentzi, D.
dc.contributor.authorKolonitsiou, F.
dc.contributor.authorMaraki, S.
dc.contributor.authorVergadi, E.
dc.contributor.authorSingh, S.
dc.contributor.authorGeorge, A.
dc.contributor.authorDharmapalan, D.
dc.contributor.authorRai, R.
dc.contributor.authorShetty, K.
dc.contributor.authorYewale, V.
dc.contributor.authorIyer, R.N.
dc.contributor.authorAlvarez-Uria, G.
dc.contributor.authorJinka, D.R.
dc.contributor.authorAshkenazi-Hoffnung, L.
dc.contributor.authorBen-Zvi, H.
dc.contributor.authorde Luca, M.
dc.contributor.authorBernaschi, P.
dc.contributor.authorPansa, P.
dc.contributor.authorBianchini, S.
dc.contributor.authorEsposito, S.
dc.contributor.authorHorikoshi, Y.
dc.contributor.authorHiguchi, H.
dc.contributor.authorCastellanos-Cruz, M.D.C.
dc.contributor.authorPichardo-Villalon, L.
dc.contributor.authorGowin, E.
dc.contributor.authorPirumova, R.
dc.contributor.authorChan, S.M.
dc.contributor.authorChew, K.L.
dc.contributor.authorNana, T.
dc.contributor.authorBandini, R.
dc.contributor.authorDramowski, A.
dc.contributor.authorWhitelaw, A.
dc.contributor.authorManzanares, A.
dc.contributor.authorOrellana, M.Á.
dc.contributor.authorMartinón Torres, Federico 
dc.contributor.authorDacosta Urbieta, A.I.
dc.contributor.authorOlson, L.
dc.contributor.authorLarsson, M.
dc.contributor.authorPreedisripipat, K.
dc.contributor.authorCressey, T.R.
dc.contributor.authorAnugulruengkitt, S.
dc.contributor.authorChatsuwan, T.
dc.contributor.authorLochindarat, S.
dc.contributor.authorMutitanon, S.
dc.contributor.authorSsengooba, W.
dc.contributor.authorTasimwa, H.B.
dc.contributor.authorMusoke, P.
dc.contributor.authorShaw, F.
dc.contributor.authorRiordan, A.
dc.contributor.authorFidler, K.
dc.contributor.authorSchilling, W.
dc.contributor.authorHatcher, J.
dc.contributor.authorBamford, A.
dc.contributor.authorMcMaster, P.
dc.contributor.authorHarkensee, C.
dc.contributor.authorMoore, J.
dc.contributor.authorSpeirs, L.
dc.contributor.authorMoriarty, P.
dc.contributor.authorChesshyre, E.
dc.contributor.authorAuckland, C.
dc.contributor.authorHindocha, A.
dc.contributor.authorAshcroft, P.
dc.contributor.authorThompson, S.
dc.contributor.authorPatel, S.
dc.contributor.authorBrowning, D.
dc.contributor.authorTran Minh, D.
dc.contributor.authorHoang Thi Bich, N.
dc.date.accessioned2025-08-26T11:09:48Z
dc.date.available2025-08-26T11:09:48Z
dc.date.issued2022
dc.identifier.citationCook A, Sharland M, Yau Y, Bielicki J, Grimwood K, Cross J, et al. Improving empiric antibiotic prescribing in pediatric bloodstream infections: a potential application of weighted-incidence syndromic combination antibiograms (WISCA). Expert Review of Anti-Infective Therapy. 2022;20(3):445-56.
dc.identifier.issn1744-8336
dc.identifier.otherhttps://portalcientifico.sergas.gal/documentos/65e4228c795b6b1f94c9a527*
dc.identifier.urihttp://hdl.handle.net/20.500.11940/20866
dc.description.abstractBackground: Increasing antibiotic resistance to WHO-recommended first- and second-line treatments of pediatric sepsis requires adaptation of prescribing guidelines. We discuss the potential and limitations of a weighted-incidence syndromic combination antibiogram (WISCA) as a practical tool for incorporating local microbiology data when assessing empiric coverage of commonly used antibiotics. Research design and methods: A brief questionnaire of 18 clinically significant isolates from pediatric blood cultures (Jan-Dec 2018) was sent to a global network of pediatric hospitals in July 2019. Weighted coverage estimates of non-antipseudomonal third-generation cephalosporins (3GC) and meropenem were estimated using Monte-Carlo simulation for each site reporting >100 isolates. Results: 52 hospitals in 23 countries in 5 WHO regions responded to the questionnaire; 13 sites met the sample size requirement. The most common isolates were S. aureus, Klebsiella spp., E. coli and Enterococcus spp. Coverage of 3GC ranged from 39% [95%CrI: 34-43%] to 73% (two sites: [95%CrI: 65-80%]; [95%CrI: 68-86%]) and meropenem coverage ranged from 54% [95%CrI: 47-60%] to 88% [95%CrI:84-91%]. Conclusions: A WISCA is a data-driven, clinically intuitive tool that can be used to compare empiric antibiotic regimens for pediatric sepsis using existing large datasets. The estimates can be further refined using more complex meta-analytical methods and patient characteristics.en
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleImproving empiric antibiotic prescribing in pediatric bloodstream infections: a potential application of weighted-incidence syndromic combination antibiograms (WISCA)*
dc.typeArticleen
dc.authorsophosCook, N. A.
dc.authorsophosSharland, M.
dc.authorsophosYau, Y.
dc.authorsophosBielicki, J.
dc.authorsophosGrimwood, K.
dc.authorsophosCross, J.
dc.authorsophosCheung, K.
dc.authorsophosParbhoo, D.
dc.authorsophosHenriques Teixeira, C.
dc.authorsophosBerezin, E. N.
dc.authorsophosBarreto da Silva, C.
dc.authorsophosAles Leal, I.
dc.authorsophosVieira Souza, C.
dc.authorsophosCarvalheiro, C. G.
dc.authorsophosde Souza, C. B. S.
dc.authorsophosTurner, P.
dc.authorsophosMiliya, T.
dc.authorsophosWu, L.
dc.authorsophosJin, P.
dc.authorsophosDeng, J.
dc.authorsophosWang, H.
dc.authorsophosFeng, J.
dc.authorsophosChen, Y.
dc.authorsophosJürna, M.
dc.authorsophosLutsar, I.
dc.authorsophosKõljalg, S.
dc.authorsophosKirjavainen, V.
dc.authorsophosKekomäki, S.
dc.authorsophosDarboe, S.
dc.authorsophosOkomo, U. A.
dc.authorsophosRicardo Araujo da Silva, A.
dc.authorsophosHübner, J.
dc.authorsophosChristner, M.
dc.authorsophosSchulze-Sturm, U.
dc.authorsophosHufnagel, M.
dc.authorsophosBluemel, B.
dc.authorsophosDimopoulou, D.
dc.authorsophosPapaevangelou, V.
dc.authorsophosGkentzi, D.
dc.authorsophosKolonitsiou, F.
dc.authorsophosMaraki, S.
dc.authorsophosVergadi, E.
dc.authorsophosSingh, S.
dc.authorsophosGeorge, A.
dc.authorsophosDharmapalan, D.
dc.authorsophosRai, R.
dc.authorsophosShetty, K.
dc.authorsophosYewale, V.
dc.authorsophosIyer, R. N.
dc.authorsophosAlvarez-Uria, G.
dc.authorsophosJinka, D. R.
dc.authorsophosAshkenazi-Hoffnung, L.
dc.authorsophosBen-Zvi, H.
dc.authorsophosde Luca, M.
dc.authorsophosBernaschi, P.
dc.authorsophosPansa, P.
dc.authorsophosBianchini, S.
dc.authorsophosEsposito, S.
dc.authorsophosHorikoshi, Y.
dc.authorsophosHiguchi, H.
dc.authorsophosCastellanos-Cruz, M. D. C.
dc.authorsophosPichardo-Villalon, L.
dc.authorsophosGowin, E.
dc.authorsophosPirumova, R.
dc.authorsophosChan, S. M.
dc.authorsophosChew, K. L.
dc.authorsophosNana, T.
dc.authorsophosBandini, R.
dc.authorsophosDramowski, A.
dc.authorsophosWhitelaw, A.
dc.authorsophosManzanares, A.
dc.authorsophosOrellana, M. Á
dc.authorsophosMartinon-Torres, F.
dc.authorsophosDacosta Urbieta, A. I.
dc.authorsophosOlson, L.
dc.authorsophosLarsson, M.
dc.authorsophosPreedisripipat, K.
dc.authorsophosCressey, T. R.
dc.authorsophosAnugulruengkitt, S.
dc.authorsophosChatsuwan, T.
dc.authorsophosLochindarat, S.
dc.authorsophosMutitanon, S.
dc.authorsophosSsengooba, W.
dc.authorsophosTasimwa, H. B.
dc.authorsophosMusoke, P.
dc.authorsophosShaw, F.
dc.authorsophosRiordan, A.
dc.authorsophosFidler, K.
dc.authorsophosSchilling, W.
dc.authorsophosHatcher, J.
dc.authorsophosBamford, A.
dc.authorsophosMcMaster, P.
dc.authorsophosHarkensee, C.
dc.authorsophosMoore, J.
dc.authorsophosSpeirs, L.
dc.authorsophosMoriarty, P.
dc.authorsophosChesshyre, E.
dc.authorsophosAuckland, C.
dc.authorsophosHindocha, A.
dc.authorsophosAshcroft, P.
dc.authorsophosThompson, S.
dc.authorsophosPatel, S.
dc.authorsophosBrowning, D.
dc.authorsophosTran Minh, D.
dc.authorsophosHoang Thi, Bich
dc.identifier.doi10.1080/14787210.2021.1967145
dc.identifier.sophos65e4228c795b6b1f94c9a527
dc.issue.number3
dc.journal.titleExpert Review of Anti-Infective Therapy*
dc.page.initial445
dc.page.final456
dc.relation.publisherversionhttps://www.tandfonline.com/doi/pdf/10.1080/14787210.2021.1967145es
dc.rights.accessRightsopenAccess
dc.subject.keywordAS Santiagoes
dc.subject.keywordCHUSes
dc.subject.keywordIDISes
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)es
dc.typesophosArtículo Originales
dc.volume.number20


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