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dc.contributor.authorRomero Picó, Amparo
dc.contributor.authorVázquez Villar, María Jesús
dc.contributor.authorGonzález Touceda, David
dc.contributor.authorFolgueira Cobos, Cintia
dc.contributor.authorSkibicka, K. P.
dc.contributor.authorAlvarez-Crespo, M.
dc.contributor.authorVan Gestel, M. A.
dc.contributor.authorVelásquez Raimundo, Douglas A.
dc.contributor.authorSchwarzer, C.
dc.contributor.authorHerzog, H.
dc.contributor.authorLópez Pérez, Miguel A.
dc.contributor.authorAdan, R. A.
dc.contributor.authorDickson, S. L.
dc.contributor.authorDiéguez González, Carlos
dc.contributor.authorNogueiras Pozo, Rubén
dc.date.accessioned2017-06-07T07:03:14Z
dc.date.available2017-06-07T07:03:14Z
dc.date.issued2013
dc.identifier.issn0893-133X
dc.identifier.urihttp://hdl.handle.net/20.500.11940/2087
dc.description.abstractThe opioid system is well recognized as an important regulator of appetite and energy balance. We now hypothesized that the hypothalamic opioid system might modulate the orexigenic effect of ghrelin. Using pharmacological and gene silencing approaches, we demonstrate that ghrelin utilizes a hypothalamic ?-opioid receptor (KOR) pathway to increase food intake in rats. Pharmacological blockade of KOR decreases the acute orexigenic effect of ghrelin. Inhibition of KOR expression in the hypothalamic arcuate nucleus is sufficient to blunt ghrelin-induced food intake. By contrast, the specific inhibition of KOR expression in the ventral tegmental area does not affect central ghrelin-induced feeding. This new pathway is independent of ghrelin-induced AMP-activated protein kinase activation, but modulates the levels of the transcription factors and orexigenic neuropeptides triggered by ghrelin to finally stimulate feeding. Our novel data implicate hypothalamic KOR signaling in the orexigenic action of ghrelin.
dc.language.isoeng
dc.subject.meshAgouti-Related Protein
dc.subject.meshAnimals
dc.subject.meshArcuate Nucleus of Hypothalamus
dc.subject.meshConditioning, Operant
dc.subject.meshDrug Interactions
dc.subject.meshEating
dc.subject.meshEnkephalins
dc.subject.meshGene Silencing
dc.subject.meshGhrelin
dc.subject.meshInfusions, Intraventricular
dc.subject.meshIntracellular Signaling Peptides and Proteins
dc.subject.meshMale
dc.subject.meshMicroinjections
dc.subject.meshNarcotic Antagonists
dc.subject.meshNeuropeptide Y/metabolism
dc.subject.meshNeuropeptides
dc.subject.meshOrexins
dc.subject.meshProtein Precursors
dc.subject.meshRats
dc.subject.meshReceptors, Ghrelin
dc.subject.meshReceptors, Opioid, kappa
dc.subject.meshReinforcement Schedule
dc.subject.meshSignal Transduction
dc.subject.meshVentral Tegmental Area
dc.titleHypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin
dc.typeArtigoes
dc.authorsophosRomero-Picó, A.
dc.authorsophosVázquez, M. J.
dc.authorsophosGonzález-Touceda, D.
dc.authorsophosFolgueira, C.
dc.authorsophosSkibicka, K. P.
dc.authorsophosAlvarez-Crespo, M.
dc.authorsophosVan Gestel, M. A.
dc.authorsophosVelásquez, D. A.
dc.authorsophosSchwarzer, C.
dc.authorsophosHerzog, H.
dc.authorsophosLópez, M.
dc.authorsophosAdan, R. A.
dc.authorsophosDickson, S. L.
dc.authorsophosDiéguez, C.
dc.authorsophosNogueiras, R.
dc.identifier.doi10.1038/npp.2013.28
dc.identifier.isi319120000015
dc.identifier.pmid23348063
dc.identifier.sophos12583
dc.issue.number7
dc.journal.titleNEUROPSYCHOPHARMACOLOGY
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago
dc.page.initial1296
dc.page.final307
dc.relation.publisherversionhttp://europepmc.org/articles/pmc3656373?pdf=render
dc.rights.accessRightsopenAccess
dc.typesophosArtículo Original
dc.volume.number38


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