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Advanced Methods for Natural Products Discovery: Bioactivity Screening, Dereplication, Metabolomics Profiling, Genomic Sequencing, Databases and Informatic Tools, and Structure Elucidation

dc.contributor.authorGaudêncio, S.P.*
dc.contributor.authorBayram, E.*
dc.contributor.authorLuki? Bilela, L.*
dc.contributor.authorCueto, M.*
dc.contributor.authorDíaz-Marrero, A.R.*
dc.contributor.authorHaznedaroglu, B.Z.*
dc.contributor.authorJiménez González, Carlos*
dc.contributor.authorMandalakis, M.*
dc.contributor.authorPereira, F.*
dc.contributor.authorReyes, F.*
dc.contributor.authorTasdemir, D.*
dc.date.accessioned2025-09-05T09:21:50Z
dc.date.available2025-09-05T09:21:50Z
dc.date.issued2023
dc.identifier.citationGaudêncio SP, Bayram E, Luki? Bilela L, Cueto M, Díaz-Marrero AR, Haznedaroglu BZ, et al. Advanced Methods for Natural Products Discovery: Bioactivity Screening, Dereplication, Metabolomics Profiling, Genomic Sequencing, Databases and Informatic Tools, and Structure Elucidation. Marine Drugs. MDPI; 2023;21(5).
dc.identifier.issn1660-3397
dc.identifier.otherhttps://portalcientifico.sergas.gal//documentos/648600d5a219857f1d789560
dc.identifier.urihttp://hdl.handle.net/20.500.11940/21027
dc.description.abstractNatural Products (NP) are essential for the discovery of novel drugs and products for numerous biotechnological applications. The NP discovery process is expensive and time-consuming, having as major hurdles dereplication (early identification of known compounds) and structure elucidation, particularly the determination of the absolute configuration of metabolites with stereogenic centers. This review comprehensively focuses on recent technological and instrumental advances, highlighting the development of methods that alleviate these obstacles, paving the way for accelerating NP discovery towards biotechnological applications. Herein, we emphasize the most innovative high-throughput tools and methods for advancing bioactivity screening, NP chemical analysis, dereplication, metabolite profiling, metabolomics, genome sequencing and/or genomics approaches, databases, bioinformatics, chemoinformatics, and three-dimensional NP structure elucidation.
dc.description.sponsorshipThis publication is based upon work from COST Action CA18238 (Ocean4Biotech), funded by the European Cooperation in Science and Technology (COST) Program in the period 2019-2023. SPG: This work is financed by national funds from FCT-Fundacao para a Ciencia e a Tecnologia, I.P., in the scope of the projects UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences-UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy-i4HB. LLB: The publication is part of a project that has received funding from the Erasmus + Project No. ECOBIAS_609967-EPP-1-2019-1-RS-EPPKA2-CBHE-JP; GA.2019-1991/001-001. Development of master curricula in ecological monitoring and aquatic bioassessment for Western Balkans HEIs/ECOBIAS. CJ: This work was supported by grants PID2021-122732OB-C22 from MCIN/AEI/10.13039/501100011033/FEDER A way to make Europe (AEI, Spanish State Agency for Research and FEDER Programme from the European Union) and RTI2018-093634-B-C22 from the State Agency for Research (AEI) of Spain, co-funded by the FEDER Programme from the European Union, and BLUEBIOLAB (0474_BLUEBIOLAB_1_E), Programme INTERREG V A of Spain-Portugal (POCTEP). FP: This work is financed by national funds from FCT-Fundacao para a Ciencia e a Tecnologia, I.P., in the scope of the project UIDB/50006/2020 of the Research Unit on Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE) and for an Assistant Research Position (CEECIND/01649/2021). MC: INTERREG-MAC2/1.1b/279 (AHIDAGRO) and the Ministerio de Ciencia e Innovacion (Spain) (grant PID2020-115979RR-C32). ARDM is supported with funds from Proyecto Intramural Especial CSIC [Ref. 202280I032].
dc.languageeng
dc.rightsAttribution 4.0 International (CC BY 4.0)*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshBiological Products *
dc.subject.meshDatabases, Factual*
dc.subject.meshMetabolomics *
dc.subject.meshComputational Biology *
dc.subject.meshGenomics *
dc.titleAdvanced Methods for Natural Products Discovery: Bioactivity Screening, Dereplication, Metabolomics Profiling, Genomic Sequencing, Databases and Informatic Tools, and Structure Elucidation
dc.typeArtigo
dc.authorsophosGaudêncio, S.P.; Bayram, E.; Luki? Bilela, L.; Cueto, M.; Díaz-Marrero, A.R.; Haznedaroglu, B.Z.; Jimenez, C.; Mandalakis, M.; Pereira, F.; Reyes, F.; Tasdemir, D.
dc.identifier.doi10.3390/md21050308
dc.identifier.sophos648600d5a219857f1d789560
dc.issue.number5
dc.journal.titleMarine Drugs*
dc.organizationInstituto de Investigación Biomédica de A Coruña (INIBIC)
dc.relation.projectIDEuropean Cooperation in Science and Technology (COST) Program [CA18238]
dc.relation.projectIDFCT-Fundacao para a Ciencia e a Tecnologia, I.P [UIDP/04378/2020, UIDB/04378/2020]
dc.relation.projectIDAssociate Laboratory Institute for Health and Bioeconomy-i4HB [LA/P/0140/2020]
dc.relation.projectIDErasmus + [ECOBIAS_609967-EPP-1-2019-1-RS-EPPKA2-CBHE-JP, GA.2019-1991/001-001]
dc.relation.projectIDAEI [PID2021-122732OB-C22, MCIN/AEI/10.13039/501100011033/FEDER]
dc.relation.projectIDSpanish State Agency for Research
dc.relation.projectIDFEDER Programme European Union
dc.relation.projectIDState Agency for Research (AEI) of Spain [RTI2018-093634-B-C22]
dc.relation.projectIDBLUEBIOLAB [0474_BLUEBIOLAB_1_E]
dc.relation.projectIDnational funds from FCT-Fundacao para a Ciencia e a Tecnologia, I.P. [UIDB/50006/2020]
dc.relation.projectIDMinisterio de Ciencia e Innovacion (Spain) [PID2020-115979RR-C32]
dc.relation.projectIDProyecto Intramural Especial CSIC [202280I032]
dc.relation.publisherversionhttps://doi.org/10.3390/md21050308
dc.rights.accessRightsopenAccess*
dc.subject.keywordINIBIC
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)
dc.typesophosArtículo de Revisión
dc.volume.number21


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