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dc.contributor.authorBrañas, F.*
dc.contributor.authorTorralba, M.*
dc.contributor.authorAntela López, Antonio *
dc.contributor.authorVergas, J.*
dc.contributor.authorRamírez, M.*
dc.contributor.authorRyan, P.*
dc.contributor.authorDronda, F.*
dc.contributor.authorGalindo, M.J.*
dc.contributor.authorMachuca, I.*
dc.contributor.authorBustinduy, M.J.*
dc.contributor.authorCabello, A.*
dc.contributor.authorMontes, M.L.*
dc.contributor.authorSánchez-Conde, M.*
dc.date.accessioned2025-09-09T10:24:58Z
dc.date.available2025-09-09T10:24:58Z
dc.date.issued2023
dc.identifier.citationBrañas F, Torralba M, Antela A, Vergas J, Ramírez M, Ryan P, et al. Effects of frailty, geriatric syndromes, and comorbidity on mortality and quality of life in older adults with HIV. BMC Geriatrics. 2023;23(1).
dc.identifier.issn1471-2318
dc.identifier.otherhttps://portalcientifico.sergas.gal//documentos/63c390f8b0644813d9026492
dc.identifier.urihttp://hdl.handle.net/20.500.11940/21413
dc.description.abstractBackground: To understand the effects of frailty, geriatric syndromes, and comorbidity on quality of life and mortality in older adults with HIV (OAWH). Methods: Cross-sectional study of the FUNCFRAIL multicenter cohort. The setting was outpatient HIV-Clinic. OAWH, 50 year or over were included. We recorded sociodemographic data, HIV infection-related data, comorbidity, frailty, geriatric syndromes (depression, cognitive impairment, falls and malnutrition), quality of life (QOL) and the estimated risk of all-cause 5-year mortality by VACS Index. Association of frailty with geriatric syndromes and comorbidity was evaluated using the Cochran-Mantel-Haenszel test. Results: Seven hundred ninety six patients were included. 24.7% were women, mean age was 58.2 (6.3). 14.7% were 65 or over. 517 (65%) patients had ?3 comorbidities, ? 1 geriatric syndrome and/or frailty. There were significant differences in the estimated risk of mortality [(frailty 10.8%) vs. (? 3 comorbidities 8.2%) vs. (? 1 geriatric syndrome 8.2%) vs. (nothing 6.2%); p = 0.01] and in the prevalence of fair or poor QOL [(frailty 71.7%) vs. (? 3 comorbidities 52%) vs. (? 1 geriatric syndrome 58.4%) vs. (nothing 51%); p = 0.01]. Cognitive impairment was significantly associated to mortality (8.7% vs. 6.2%; p = 0.02) and depression to poor QOL [76.5% vs. 50%; p = 0.01]. Conclusions: Frailty, geriatric syndromes, and comorbidity had negative effects on mortality and QOL, but frailty had the greatest negative effect out of the three factors. Our results should be a wake-up call to standardize the screening for frailty and geriatric syndromes in OAWH in the clinical practice. Trial registration: NCT03558438.
dc.description.sponsorshipFUNCFRAIL study was supported by Instituto de Salud Carlos III [PI17/00859] (Co-funded by European Regional Development Fund/European Social Fund A way to make Europe/Investing in your future); and partially supported by an Investigator Studies Program (MISP) research grant from Merck Sharp &Dohme Corp [IISP57179].The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.languageeng
dc.rightsAttribution 4.0 International (CC BY 4.0)*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshHumans *
dc.subject.meshFemale *
dc.subject.meshAged *
dc.subject.meshMale *
dc.subject.meshFrailty *
dc.subject.meshHIV Infections *
dc.subject.meshQuality of Life *
dc.subject.meshHIV *
dc.subject.meshSyndrome *
dc.subject.meshCross-Sectional Studies *
dc.subject.meshComorbidity *
dc.subject.meshGeriatric Assessment *
dc.subject.meshFrail Elderly *
dc.titleEffects of frailty, geriatric syndromes, and comorbidity on mortality and quality of life in older adults with HIV
dc.typeArtigo
dc.authorsophosBrañas, F.; Torralba, M.; Antela, A.; Vergas, J.; Ramírez, M.; Ryan, P.; Dronda, F.; Galindo, M.J.; Machuca, I.; Bustinduy, M.J.; Cabello, A.; Montes, M.L.; Sánchez-Conde, M.
dc.identifier.doi10.1186/s12877-022-03719-8
dc.identifier.sophos63c390f8b0644813d9026492
dc.issue.number1
dc.journal.titleBMC Geriatrics*
dc.organizationServizo Galego de Saúde::Áreas Sanitarias (A.S.) - Complexo Hospitalario Universitario de Santiago::Medicina interna
dc.relation.projectIDInstituto de Salud Carlos III
dc.relation.projectIDInvestigator Studies Program (MISP) research Merck Sharp Dohme Corp [PI17/00859]
dc.relation.projectIDEuropean Regional Development Fund/European Social Fund [IISP57179]
dc.relation.publisherversionhttps://doi.org/10.1186/s12877-022-03719-8
dc.rights.accessRightsopenAccess*
dc.subject.keywordAS Santiago
dc.subject.keywordCHUS
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)
dc.typesophosArtículo Original
dc.volume.number23


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