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Effects of frailty, geriatric syndromes, and comorbidity on mortality and quality of life in older adults with HIV
dc.contributor.author | Brañas, F. | * |
dc.contributor.author | Torralba, M. | * |
dc.contributor.author | Antela López, Antonio | * |
dc.contributor.author | Vergas, J. | * |
dc.contributor.author | Ramírez, M. | * |
dc.contributor.author | Ryan, P. | * |
dc.contributor.author | Dronda, F. | * |
dc.contributor.author | Galindo, M.J. | * |
dc.contributor.author | Machuca, I. | * |
dc.contributor.author | Bustinduy, M.J. | * |
dc.contributor.author | Cabello, A. | * |
dc.contributor.author | Montes, M.L. | * |
dc.contributor.author | Sánchez-Conde, M. | * |
dc.date.accessioned | 2025-09-09T10:24:58Z | |
dc.date.available | 2025-09-09T10:24:58Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Brañas F, Torralba M, Antela A, Vergas J, Ramírez M, Ryan P, et al. Effects of frailty, geriatric syndromes, and comorbidity on mortality and quality of life in older adults with HIV. BMC Geriatrics. 2023;23(1). | |
dc.identifier.issn | 1471-2318 | |
dc.identifier.other | https://portalcientifico.sergas.gal//documentos/63c390f8b0644813d9026492 | |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/21413 | |
dc.description.abstract | Background: To understand the effects of frailty, geriatric syndromes, and comorbidity on quality of life and mortality in older adults with HIV (OAWH). Methods: Cross-sectional study of the FUNCFRAIL multicenter cohort. The setting was outpatient HIV-Clinic. OAWH, 50 year or over were included. We recorded sociodemographic data, HIV infection-related data, comorbidity, frailty, geriatric syndromes (depression, cognitive impairment, falls and malnutrition), quality of life (QOL) and the estimated risk of all-cause 5-year mortality by VACS Index. Association of frailty with geriatric syndromes and comorbidity was evaluated using the Cochran-Mantel-Haenszel test. Results: Seven hundred ninety six patients were included. 24.7% were women, mean age was 58.2 (6.3). 14.7% were 65 or over. 517 (65%) patients had ?3 comorbidities, ? 1 geriatric syndrome and/or frailty. There were significant differences in the estimated risk of mortality [(frailty 10.8%) vs. (? 3 comorbidities 8.2%) vs. (? 1 geriatric syndrome 8.2%) vs. (nothing 6.2%); p = 0.01] and in the prevalence of fair or poor QOL [(frailty 71.7%) vs. (? 3 comorbidities 52%) vs. (? 1 geriatric syndrome 58.4%) vs. (nothing 51%); p = 0.01]. Cognitive impairment was significantly associated to mortality (8.7% vs. 6.2%; p = 0.02) and depression to poor QOL [76.5% vs. 50%; p = 0.01]. Conclusions: Frailty, geriatric syndromes, and comorbidity had negative effects on mortality and QOL, but frailty had the greatest negative effect out of the three factors. Our results should be a wake-up call to standardize the screening for frailty and geriatric syndromes in OAWH in the clinical practice. Trial registration: NCT03558438. | |
dc.description.sponsorship | FUNCFRAIL study was supported by Instituto de Salud Carlos III [PI17/00859] (Co-funded by European Regional Development Fund/European Social Fund A way to make Europe/Investing in your future); and partially supported by an Investigator Studies Program (MISP) research grant from Merck Sharp &Dohme Corp [IISP57179].The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | |
dc.language | eng | |
dc.rights | Attribution 4.0 International (CC BY 4.0) | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Female | * |
dc.subject.mesh | Aged | * |
dc.subject.mesh | Male | * |
dc.subject.mesh | Frailty | * |
dc.subject.mesh | HIV Infections | * |
dc.subject.mesh | Quality of Life | * |
dc.subject.mesh | HIV | * |
dc.subject.mesh | Syndrome | * |
dc.subject.mesh | Cross-Sectional Studies | * |
dc.subject.mesh | Comorbidity | * |
dc.subject.mesh | Geriatric Assessment | * |
dc.subject.mesh | Frail Elderly | * |
dc.title | Effects of frailty, geriatric syndromes, and comorbidity on mortality and quality of life in older adults with HIV | |
dc.type | Artigo | |
dc.authorsophos | Brañas, F.; Torralba, M.; Antela, A.; Vergas, J.; Ramírez, M.; Ryan, P.; Dronda, F.; Galindo, M.J.; Machuca, I.; Bustinduy, M.J.; Cabello, A.; Montes, M.L.; Sánchez-Conde, M. | |
dc.identifier.doi | 10.1186/s12877-022-03719-8 | |
dc.identifier.sophos | 63c390f8b0644813d9026492 | |
dc.issue.number | 1 | |
dc.journal.title | BMC Geriatrics | * |
dc.organization | Servizo Galego de Saúde::Áreas Sanitarias (A.S.) - Complexo Hospitalario Universitario de Santiago::Medicina interna | |
dc.relation.projectID | Instituto de Salud Carlos III | |
dc.relation.projectID | Investigator Studies Program (MISP) research Merck Sharp Dohme Corp [PI17/00859] | |
dc.relation.projectID | European Regional Development Fund/European Social Fund [IISP57179] | |
dc.relation.publisherversion | https://doi.org/10.1186/s12877-022-03719-8 | |
dc.rights.accessRights | openAccess | * |
dc.subject.keyword | AS Santiago | |
dc.subject.keyword | CHUS | |
dc.typefides | Artículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis) | |
dc.typesophos | Artículo Original | |
dc.volume.number | 23 |
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