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Serum levels of tissue polypeptide specific antigen are correlated with hepatocyte cytokeratin expression in alcoholic liver disease.

dc.contributor.authorGonzález Quintela, Arturo 
dc.contributor.authorMella Perez, Carmen
dc.contributor.authorAbdulkader Nallib, Ihab 
dc.contributor.authorPérez, LF
dc.contributor.authorCampos Franco, Joaquín 
dc.contributor.authorOtero Antón, Esteban 
dc.contributor.authorForteza Vila, Jerónimo 
dc.date.accessioned2026-01-23T07:28:25Z
dc.date.available2026-01-23T07:28:25Z
dc.date.issued2004-09
dc.identifier.issn0145-6008
dc.identifier.urihttp://hdl.handle.net/20.500.11940/22441
dc.description.abstractSerum levels of the tumor marker tissue polypeptide specific antigen (TPS, cytokeratin 18 fragments) are increased in patients with alcoholic liver disease, particularly in cases of alcoholic hepatitis. Mallory bodies, characteristic of alcoholic hepatitis, are cytokeratin 8 and 18 aggregates. The study was aimed at investigating the possible relationship of serum TPS levels with hepatocyte cytokeratin expression in patients with alcoholic liver disease. Twenty-four patients with alcoholic liver disease were studied. Immunohistochemical staining for cytokeratins 8 and 18 was performed in liver specimens by means of CAM 5.2 monoclonal antibody. The number of hepatocytes containing CAM 5.2-reactive cytokeratin inclusions was compared with serum TPS levels. The vast majority of alcoholics (95%) showed increased (>100 units/liter) serum TPS levels. Serum TPS levels were significantly correlated with the number of hepatocyte cytokeratin inclusions. Serum TPS levels can predict hepatocyte cytokeratin expression in patients with alcoholic liver disease.es
dc.language.isoenges
dc.subject.meshAdult *
dc.subject.meshHumans *
dc.subject.meshLiver Diseases *
dc.subject.meshCytoskeleton *
dc.subject.meshHepatocytes *
dc.subject.meshStatistics *
dc.subject.meshKeratins *
dc.subject.meshMiddle Aged *
dc.subject.meshBilirubin *
dc.subject.meshFatty Liver *
dc.subject.meshPeptides *
dc.subject.meshMale *
dc.subject.meshLiver *
dc.subject.meshFemale *
dc.subject.meshLinear Models *
dc.titleSerum levels of tissue polypeptide specific antigen are correlated with hepatocyte cytokeratin expression in alcoholic liver disease.es
dc.typeArtigoes
dc.bbddEmbase*
dc.bbddWOK*
dc.identifier.doi10.1097/01.alc.0000139824.23340.74
dc.identifier.pmid15365314
dc.issue.number9es
dc.journal.titleAlcoholism, clinical and experimental researches
dc.journal.titleALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH*
dc.organizationServizo Galego de Saúde::Áreas Sanitarias (A.S.)::Área Sanitaria de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostelaes
dc.page.initial1413es
dc.page.final1418es
dc.rights.accessRightsembargoedAccesses
dc.subject.decsmodelos lineales *
dc.subject.decscitoesqueleto *
dc.subject.decshumanos *
dc.subject.decsenfermedades hepáticas *
dc.subject.decsmediana edad *
dc.subject.decshígado *
dc.subject.decsadulto *
dc.subject.decspéptidos *
dc.subject.decsbilirrubina *
dc.subject.decsestadísticas *
dc.subject.decshepatocitos *
dc.subject.decsqueratinas *
dc.subject.decshígado graso *
dc.subject.keywordCHUSes
dc.typefidesArtigo Científico (inclue Orixinal, Orixinal breve, Revisión Sistemática e Meta-análisis)es
dc.typesophosArtículo Originales
dc.volume.number28es


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Dig Dis Sci . 2009 Mar;54(3):648-53
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