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dc.contributor.authorVan Os, J.
dc.contributor.authorRutten, B. P.
dc.contributor.authorMyin-Germeys, I.
dc.contributor.authorDelespaul, P.
dc.contributor.authorViechtbauer, W.
dc.contributor.authorVan Zelst, C.
dc.contributor.authorBruggeman, R.
dc.contributor.authorReininghaus, U.
dc.contributor.authorMorgan, C.
dc.contributor.authorMurray, R. M.
dc.contributor.authorDi Forti, M.
dc.contributor.authorMcGuire, P.
dc.contributor.authorValmaggia, L. R.
dc.contributor.authorKempton, M. J.
dc.contributor.authorGayer-Anderson, C.
dc.contributor.authorHubbard, K.
dc.contributor.authorBeards, S.
dc.contributor.authorStilo, S. A.
dc.contributor.authorOnyejiaka, A.
dc.contributor.authorBourque, F.
dc.contributor.authorModinos, G.
dc.contributor.authorTognin, S.
dc.contributor.authorCalem, M.
dc.contributor.authorO'Donovan, M. C.
dc.contributor.authorOwen, M. J.
dc.contributor.authorHolmans, P.
dc.contributor.authorWilliams, N.
dc.contributor.authorCraddock, N.
dc.contributor.authorRichards, A.
dc.contributor.authorHumphreys, I.
dc.contributor.authorMeyer-Lindenberg, A.
dc.contributor.authorLeweke, F. M.
dc.contributor.authorTost, H.
dc.contributor.authorAkdeniz, C.
dc.contributor.authorRohleder, C.
dc.contributor.authorBumb, J. M.
dc.contributor.authorSchwarz, E.
dc.contributor.authorAlptekin, K.
dc.contributor.authorÜçok, A.
dc.contributor.authorSaka, M. C.
dc.contributor.authorAtbagoǧlu, E. C.
dc.contributor.authorGülöksüz, S.
dc.contributor.authorGumus-Akay, G.
dc.contributor.authorCihan, B.
dc.contributor.authorKaradaǧ, H.
dc.contributor.authorSoygür, H.
dc.contributor.authorCankurtaran, E. S.
dc.contributor.authorUlusoy, S.
dc.contributor.authorAkdede, B.
dc.contributor.authorBinbay, T.
dc.contributor.authorAyer, A.
dc.contributor.authorNoyan, H.
dc.contributor.authorKaradayi, G.
dc.contributor.authorAkturan, E.
dc.contributor.authorUlaş, H.
dc.contributor.authorArango, C.
dc.contributor.authorParellada, M.
dc.contributor.authorBernardo, M.
dc.contributor.authorSanjuán, J.
dc.contributor.authorBobes, J.
dc.contributor.authorArrojo Romero, Manuel 
dc.contributor.authorSantos, J. L.
dc.contributor.authorCuadrado, P.
dc.contributor.authorSolano, J. J. R.
dc.contributor.authorCarracedo Álvarez, Ángel
dc.contributor.authorBernardo, E. G.
dc.contributor.authorRoldán, L.
dc.contributor.authorLópez, G.
dc.contributor.authorCabrera, B.
dc.contributor.authorCruz, S.
dc.contributor.authorMesa, E. M. D.
dc.contributor.authorPouso, M.
dc.contributor.authorJiménez, E.
dc.contributor.authorSánchez, T.
dc.contributor.authorRapado, M.
dc.contributor.authorGonzález, E.
dc.contributor.authorMartínez, C.
dc.contributor.authorSánchez, E.
dc.contributor.authorOlmeda, M. S.
dc.contributor.authorDe Haan, L.
dc.contributor.authorVelthorst, E.
dc.contributor.authorVan Der Gaag, M.
dc.contributor.authorSelten, J. P.
dc.contributor.authorVan Dam, D.
dc.contributor.authorVan Der Ven, E.
dc.contributor.authorVan Der Meer, F.
dc.contributor.authorMesschaert, E.
dc.contributor.authorKraan, T.
dc.contributor.authorBurger, N.
dc.contributor.authorLeboyer, M.
dc.contributor.authorSzoke, A.
dc.contributor.authorSchürhoff, F.
dc.contributor.authorLlorca, P. M.
dc.contributor.authorJamain, S.
dc.contributor.authorTortelli, A.
dc.contributor.authorFrijda, F.
dc.contributor.authorVilain, J.
dc.contributor.authorGalliot, A. M.
dc.contributor.authorBaudin, G.
dc.contributor.authorFerchiou, A.
dc.contributor.authorRichard, J. R.
dc.contributor.authorBulzacka, E.
dc.contributor.authorCharpeaud, T.
dc.contributor.authorTronche, A. M.
dc.contributor.authorDe Hert, M.
dc.contributor.authorVan Winkel, R.
dc.contributor.authorDecoster, J.
dc.contributor.authorDerom, C.
dc.contributor.authorThiery, E.
dc.contributor.authorStefanis, N. C.
dc.contributor.authorSachs, G.
dc.contributor.authorAschauer, H.
dc.contributor.authorLasser, I.
dc.contributor.authorWinklbaur, B.
dc.contributor.authorSchlögelhofer, M.
dc.contributor.authorRiecher-Rössler, A.
dc.contributor.authorBorgwardt, S.
dc.contributor.authorWalter, A.
dc.contributor.authorHarrisberger, F.
dc.contributor.authorSmieskova, R.
dc.contributor.authorRapp, C.
dc.contributor.authorIttig, S.
dc.contributor.authorSoguel-Dit-Piquard, F.
dc.contributor.authorStuderus, E.
dc.contributor.authorKlosterkötter, J.
dc.contributor.authorRuhrmann, S.
dc.contributor.authorParuch, J.
dc.contributor.authorJulkowski, D.
dc.contributor.authorHilboll, D.
dc.contributor.authorSham, P. C.
dc.contributor.authorCherny, S. S.
dc.contributor.authorChen, E. Y. H.
dc.contributor.authorCampbell, D. D.
dc.contributor.authorLi, M.
dc.contributor.authorRomeo-Casabona, C. M.
dc.contributor.authorCirión, A. E.
dc.contributor.authorMora, A. U.
dc.contributor.authorJones, P.
dc.contributor.authorKirkbride, J.
dc.contributor.authorCannon, M.
dc.contributor.authorRujescu, D.
dc.contributor.authorTarricone, I.
dc.contributor.authorBerardi, D.
dc.contributor.authorBonora, E.
dc.contributor.authorSeri, M.
dc.contributor.authorMarcacci, T.
dc.contributor.authorChiri, L.
dc.contributor.authorChierzi, F.
dc.contributor.authorStorbini, V.
dc.contributor.authorBraca, M.
dc.contributor.authorMinenna, M. G.
dc.contributor.authorDonegani, I.
dc.contributor.authorFioritti, A.
dc.contributor.authorLa Barbera, D.
dc.contributor.authorLa Cascia, C. E.
dc.contributor.authorMulè, A.
dc.contributor.authorSideli, L.
dc.contributor.authorSartorio, R.
dc.contributor.authorFerraro, L.
dc.contributor.authorTripoli, G.
dc.contributor.authorSeminerio, F.
dc.contributor.authorMarinaro, A. M.
dc.contributor.authorMcGorry, P.
dc.contributor.authorNelson, B.
dc.contributor.authorAmminger, G. P.
dc.contributor.authorPantelis, C.
dc.contributor.authorMenezes, P. R.
dc.contributor.authorDel-Ben, C. M.
dc.contributor.authorTenan, S. H. G.
dc.contributor.authorShuhama, R.
dc.contributor.authorRuggeri, M.
dc.contributor.authorTosato, S.
dc.contributor.authorLasalvia, A.
dc.contributor.authorBonetto, C.
dc.contributor.authorIra, E.
dc.contributor.authorNordentoft, M.
dc.contributor.authorKrebs, M. O.
dc.contributor.authorBarrantes-Vidal, N.
dc.contributor.authorCristóbal, P.
dc.contributor.authorKwapil, T. R.
dc.contributor.authorBrietzke, E.
dc.contributor.authorBressan, R. A.
dc.contributor.authorGadelha, A.
dc.contributor.authorMaric, N. P.
dc.contributor.authorAndric, S.
dc.contributor.authorMihaljevic, M.
dc.contributor.authorMirjanic, T.
dc.date.accessioned2017-06-07T06:53:14Z
dc.date.available2017-06-07T06:53:14Z
dc.date.issued2014
dc.identifier.issn0586-7614
dc.identifier.urihttp://hdl.handle.net/20.500.11940/225
dc.description.abstractRecent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype.
dc.language.isoeng
dc.subject.meshGene-Environment Interaction
dc.subject.meshGenetic Predisposition to Disease
dc.subject.meshHumans
dc.subject.meshSchizophrenia
dc.subject.meshSchizophrenic Psychology
dc.subject.meshSocial Environment
dc.titleIdentifying gene-environment interactions in schizophrenia: Contemporary challenges for integrated, large-scale investigations
dc.typeArtigoes
dc.authorsophosVan Os, J.
dc.authorsophosRutten, B. P.
dc.authorsophosMyin-Germeys, I.
dc.authorsophosDelespaul, P.
dc.authorsophosViechtbauer, W.
dc.authorsophosVan Zelst, C.
dc.authorsophosBruggeman, R.
dc.authorsophosReininghaus, U.
dc.authorsophosMorgan, C.
dc.authorsophosMurray, R. M.
dc.authorsophosDi Forti, M.
dc.authorsophosMcGuire, P.
dc.authorsophosValmaggia, L. R.
dc.authorsophosKempton, M. J.
dc.authorsophosGayer-Anderson, C.
dc.authorsophosHubbard, K.
dc.authorsophosBeards, S.
dc.authorsophosStilo, S. A.
dc.authorsophosOnyejiaka, A.
dc.authorsophosBourque, F.
dc.authorsophosModinos, G.
dc.authorsophosTognin, S.
dc.authorsophosCalem, M.
dc.authorsophosO'Donovan, M. C.
dc.authorsophosOwen, M. J.
dc.authorsophosHolmans, P.
dc.authorsophosWilliams, N.
dc.authorsophosCraddock, N.
dc.authorsophosRichards, A.
dc.authorsophosHumphreys, I.
dc.authorsophosMeyer-Lindenberg, A.
dc.authorsophosLeweke, F. M.
dc.authorsophosTost, H.
dc.authorsophosAkdeniz, C.
dc.authorsophosRohleder, C.
dc.authorsophosBumb, J. M.
dc.authorsophosSchwarz, E.
dc.authorsophosAlptekin, K.
dc.authorsophosÜçok, A.
dc.authorsophosSaka, M. C.
dc.authorsophosAtbagoǧlu, E. C.
dc.authorsophosGülöksüz, S.
dc.authorsophosGumus-Akay, G.
dc.authorsophosCihan, B.
dc.authorsophosKaradaǧ, H.
dc.authorsophosSoygür, H.
dc.authorsophosCankurtaran, E. S.
dc.authorsophosUlusoy, S.
dc.authorsophosAkdede, B.
dc.authorsophosBinbay, T.
dc.authorsophosAyer, A.
dc.authorsophosNoyan, H.
dc.authorsophosKaradayi, G.
dc.authorsophosAkturan, E.
dc.authorsophosUlaş, H.
dc.authorsophosArango, C.
dc.authorsophosParellada, M.
dc.authorsophosBernardo, M.
dc.authorsophosSanjuán, J.
dc.authorsophosBobes, J.
dc.authorsophosArrojo, M.
dc.authorsophosSantos, J. L.
dc.authorsophosCuadrado, P.
dc.authorsophosSolano, J. J. R.
dc.authorsophosCarracedo, A.
dc.authorsophosBernardo, E. G.
dc.authorsophosRoldán, L.
dc.authorsophosLópez, G.
dc.authorsophosCabrera, B.
dc.authorsophosCruz, S.
dc.authorsophosMesa, E. M. D.
dc.authorsophosPouso, M.
dc.authorsophosJiménez, E.
dc.authorsophosSánchez, T.
dc.authorsophosRapado, M.
dc.authorsophosGonzález, E.
dc.authorsophosMartínez, C.
dc.authorsophosSánchez, E.
dc.authorsophosOlmeda, M. S.
dc.authorsophosDe Haan, L.
dc.authorsophosVelthorst, E.
dc.authorsophosVan Der Gaag, M.
dc.authorsophosSelten, J. P.
dc.authorsophosVan Dam, D.
dc.authorsophosVan Der Ven, E.
dc.authorsophosVan Der Meer, F.
dc.authorsophosMesschaert, E.
dc.authorsophosKraan, T.
dc.authorsophosBurger, N.
dc.authorsophosLeboyer, M.
dc.authorsophosSzoke, A.
dc.authorsophosSchürhoff, F.
dc.authorsophosLlorca, P. M.
dc.authorsophosJamain, S.
dc.authorsophosTortelli, A.
dc.authorsophosFrijda, F.
dc.authorsophosVilain, J.
dc.authorsophosGalliot, A. M.
dc.authorsophosBaudin, G.
dc.authorsophosFerchiou, A.
dc.authorsophosRichard, J. R.
dc.authorsophosBulzacka, E.
dc.authorsophosCharpeaud, T.
dc.authorsophosTronche, A. M.
dc.authorsophosDe Hert, M.
dc.authorsophosVan Winkel, R.
dc.authorsophosDecoster, J.
dc.authorsophosDerom, C.
dc.authorsophosThiery, E.
dc.authorsophosStefanis, N. C.
dc.authorsophosSachs, G.
dc.authorsophosAschauer, H.
dc.authorsophosLasser, I.
dc.authorsophosWinklbaur, B.
dc.authorsophosSchlögelhofer, M.
dc.authorsophosRiecher-Rössler, A.
dc.authorsophosBorgwardt, S.
dc.authorsophosWalter, A.
dc.authorsophosHarrisberger, F.
dc.authorsophosSmieskova, R.
dc.authorsophosRapp, C.
dc.authorsophosIttig, S.
dc.authorsophosSoguel-Dit-Piquard, F.
dc.authorsophosStuderus, E.
dc.authorsophosKlosterkötter, J.
dc.authorsophosRuhrmann, S.
dc.authorsophosParuch, J.
dc.authorsophosJulkowski, D.
dc.authorsophosHilboll, D.
dc.authorsophosSham, P. C.
dc.authorsophosCherny, S. S.
dc.authorsophosChen, E. Y. H.
dc.authorsophosCampbell, D. D.
dc.authorsophosLi, M.
dc.authorsophosRomeo-Casabona, C. M.
dc.authorsophosCirión, A. E.
dc.authorsophosMora, A. U.
dc.authorsophosJones, P.
dc.authorsophosKirkbride, J.
dc.authorsophosCannon, M.
dc.authorsophosRujescu, D.
dc.authorsophosTarricone, I.
dc.authorsophosBerardi, D.
dc.authorsophosBonora, E.
dc.authorsophosSeri, M.
dc.authorsophosMarcacci, T.
dc.authorsophosChiri, L.
dc.authorsophosChierzi, F.
dc.authorsophosStorbini, V.
dc.authorsophosBraca, M.
dc.authorsophosMinenna, M. G.
dc.authorsophosDonegani, I.
dc.authorsophosFioritti, A.
dc.authorsophosLa Barbera, D.
dc.authorsophosLa Cascia, C. E.
dc.authorsophosMulè, A.
dc.authorsophosSideli, L.
dc.authorsophosSartorio, R.
dc.authorsophosFerraro, L.
dc.authorsophosTripoli, G.
dc.authorsophosSeminerio, F.
dc.authorsophosMarinaro, A. M.
dc.authorsophosMcGorry, P.
dc.authorsophosNelson, B.
dc.authorsophosAmminger, G. P.
dc.authorsophosPantelis, C.
dc.authorsophosMenezes, P. R.
dc.authorsophosDel-Ben, C. M.
dc.authorsophosTenan, S. H. G.
dc.authorsophosShuhama, R.
dc.authorsophosRuggeri, M.
dc.authorsophosTosato, S.
dc.authorsophosLasalvia, A.
dc.authorsophosBonetto, C.
dc.authorsophosIra, E.
dc.authorsophosNordentoft, M.
dc.authorsophosKrebs, M. O.
dc.authorsophosBarrantes-Vidal, N.
dc.authorsophosCristóbal, P.
dc.authorsophosKwapil, T. R.
dc.authorsophosBrietzke, E.
dc.authorsophosBressan, R. A.
dc.authorsophosGadelha, A.
dc.authorsophosMaric, N. P.
dc.authorsophosAndric, S.
dc.authorsophosMihaljevic, M.
dc.authorsophosMirjanic, T.
dc.identifier.doi10.1093/schbul/sbu069
dc.identifier.isi338130300004
dc.identifier.pmid24860087
dc.identifier.sophos15745
dc.issue.number4
dc.journal.titleSCHIZOPHRENIA BULLETIN
dc.organizationConsellería de Sanidade::Fundación pública Galega de Medicina Xenómica
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago - Complexo Hospitalario Universitario de Santiago::Psiquiatría
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago
dc.page.initial729
dc.page.final736
dc.rights.accessRightsopenAccess
dc.typesophosArtículo Original
dc.volume.number40


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