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dc.contributor.authorJiang, Xuejuan
dc.contributor.authorEsteban Castelao, J.
dc.contributor.authorVandenberg, David
dc.contributor.authorCarracedo, Angel
dc.contributor.authorRedondo, Carmen M.
dc.contributor.authorConti, David V.
dc.contributor.authorParedes Cotore, Jesus P.
dc.contributor.authorPotter, John D.
dc.contributor.authorNewcomb, Polly A.
dc.contributor.authorPassarelli, Michael N.
dc.contributor.authorJenkins, Mark A.
dc.contributor.authorHopper, John L.
dc.contributor.authorGallinger, Steven
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorMartinez, Maria E.
dc.contributor.authorAhnen, Dennis J.
dc.contributor.authorBaron, John A.
dc.contributor.authorLindor, Noralane M.
dc.contributor.authorHaile, Robert W.
dc.contributor.authorGago Dominguez, Manuela
dc.date.accessioned2017-06-07T07:04:37Z
dc.date.available2017-06-07T07:04:37Z
dc.date.issued2013
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/20.500.11940/2305
dc.description.abstractBACKGROUND: Recent genome-wide studies identified a risk locus for colorectal cancer at 18q21, which maps to the SMAD7 gene. Our objective was to confirm the association between SMAD7 SNPs and colorectal cancer risk in the multi-center Colon Cancer Family Registry. MATERIALS AND METHODS: 23 tagging SNPs in the SMAD7 gene were genotyped among 1,592 population-based and 253 clinic-based families. The SNP-colorectal cancer associations were assessed in multivariable conditional logistic regression. RESULTS: Among the population-based families, both SNPs rs12953717 (odds ratio, 1.29; 95% confidence interval, 1.12-1.49), and rs11874392 (odds ratio, 0.80; 95% confidence interval, 0.70-0.92) were associated with risk of colorectal cancer. These associations were similar among the population- and the clinic-based families, though they were significant only among the former. Marginally significant differences in the SNP-colorectal cancer associations were observed by use of nonsteroidal anti-inflammatory drugs, cigarette smoking, body mass index, and history of polyps. CONCLUSIONS: SMAD7 SNPs were associated with colorectal cancer risk in the Colon Cancer Family Registry. There was evidence suggesting that the association between rs12953717 and colorectal cancer risk may be modified by factors such as smoking and use of nonsteroidal anti-inflammatory drugs.
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal
dc.subject.meshBody Mass Index
dc.subject.meshCase-Control Studies
dc.subject.meshColonic Polyps
dc.subject.meshColorectal Neoplasms
dc.subject.meshFemale
dc.subject.meshGenetic Predisposition to Disease
dc.subject.meshHumans
dc.subject.meshLogistic Models
dc.subject.meshMiddle Aged
dc.subject.meshOdds Ratio
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshRegistries
dc.subject.meshRisk
dc.subject.meshSmad7 Protein
dc.subject.meshSmoking
dc.titleGenetic Variations in SMAD7 Are Associated with Colorectal Cancer Risk in the Colon Cancer Family Registry
dc.typeArtigoes
dc.rights.licenseAtribución 4.0 Internacional
dc.authorsophosJiang, Xuejuan
dc.authorsophosEsteban Castelao, J.
dc.authorsophosVandenberg, David
dc.authorsophosCarracedo, Angel
dc.authorsophosRedondo, Carmen M.
dc.authorsophosConti, David V.
dc.authorsophosParedes Cotore, Jesus P.
dc.authorsophosPotter, John D.
dc.authorsophosNewcomb, Polly A.
dc.authorsophosPassarelli, Michael N.
dc.authorsophosJenkins, Mark A.
dc.authorsophosHopper, John L.
dc.authorsophosGallinger, Steven
dc.authorsophosLe Marchand, Loic
dc.authorsophosMartinez, Maria E.
dc.authorsophosAhnen, Dennis J.
dc.authorsophosBaron, John A.
dc.authorsophosLindor, Noralane M.
dc.authorsophosHaile, Robert W.
dc.authorsophosGago-Dominguez, Manuela
dc.identifier.doi10.1371/journal.pone.0060464
dc.identifier.isi318840100075
dc.identifier.pmid23560096
dc.identifier.sophos13046
dc.issue.number4
dc.journal.titlePLoS One
dc.organizationConsellería de Sanidade::Fundación pública Galega de Medicina Xenómica
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Vigo::IBI - Instituto de Investigación Biomédica de Ourense, Pontevedra y Vigo::Fundación Biomédica del Complexo Hospitalario Universitario de Vigo
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago - Complexo Hospitalario Universitario de Santiago::Cirurxía Xeral e dixestiva
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago
dc.rights.accessRightsopenAccess
dc.subject.decsAntiinflamatorios no Esteroideos
dc.subject.decsNeoplasias Colorrectales
dc.subject.decsPredisposición Genética a la Enfermedad
dc.subject.decsPolimorfismo de Nucleótido Simple
dc.subject.decsProteína smad7
dc.subject.decsModelos Logísticos
dc.typesophosArtículo Original
dc.volume.number8


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