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Cardiotrophin-1 plasma levels are associated with the severity of hypertrophy in hypertrophic cardiomyopathy

Monserrat Iglesias, Lorenzo; López, Begoña; González, Arantxa; Hermida Prieto, Manuel; Barriales Villa, Roberto; Ortiz Genga, Martín; Barriales Villa, Roberto; Castro Beiras, Alfonso; Díez, Javier
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URI: http://hdl.handle.net/20.500.11940/3016
PMID: 21059734
DOI: 10.1093/eurheartj/ehq400
ISSN: 0195-668X
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Eur Heart J . 2011 Jan;32(2):177-83 (264.4Kb)
Fecha de publicación
2011
Título de revista
European Heart Journal
Tipo de contenido
Artigo
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AIMS: Cardiotrophin-1 (CT-1) is a cytokine that induces hypertrophy in cardiomyocytes and is associated with left ventricular hypertrophy (LVH) in hypertensive patients. The objective of this study was to evaluate whether plasma CT-1 is associated with hypertrophic cardiomyopathy (HCM). METHODS AND RESULTS: The study was performed in 124 patients with HCM. All patients underwent a full clinical evaluation and an echocardiogram. Left ventricular hypertrophy was evaluated by the measurement of the maximal LV wall thickness and the Spirito's LVH score. Plasma CT-1 was measured by an enzyme-linked immunosorbent assay. Compared with controls, patients with HCM exhibited higher (P < 0.001) plasma CT-1 levels. Significant correlations were found between CT-1 and maximal LV wall thickness (r = 0.284, P = 0.001) and the Spirito's LVH score (r = 0.287, P = 0.006) in HCM patients. In addition, the levels of CT-1 were higher (P = 0.02) in patients with severe LVH (maximal LV wall thickness >/=30 mm) than in patients with mild or moderate LVH (maximal LV wall thickness <30 mm). CONCLUSIONS: These findings show that plasma CT-1 is associated with the severity of LVH in patients with HCM. Further studies are required to ascertain whether CT-1 is a diagnostic biomarker of this cardiomyopathy.

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