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Diagnostic accuracy of fecal immunochemical test in average- and familial-risk colorectal cancer screening
dc.contributor.author | Cubiella, J. | |
dc.contributor.author | Castro, I. | |
dc.contributor.author | Hernandez, V. | |
dc.contributor.author | Gonzalez-Mao, C. | |
dc.contributor.author | Rivera, C. | |
dc.contributor.author | Iglesias, F. | |
dc.contributor.author | Alves, M. T. | |
dc.contributor.author | Cid, L. | |
dc.contributor.author | Soto, S. | |
dc.contributor.author | De-Castro, L. | |
dc.contributor.author | Vega, P. | |
dc.contributor.author | Hermo, J. A. | |
dc.contributor.author | Macenlle, R. | |
dc.contributor.author | Martinez, A. | |
dc.contributor.author | Estevez, P. | |
dc.contributor.author | Cid, E. | |
dc.contributor.author | Herreros-Villanueva, M. | |
dc.contributor.author | Portillo, I. | |
dc.contributor.author | Bujanda, L. | |
dc.contributor.author | Fernandez-Seara, J. | |
dc.date.accessioned | 2017-06-07T06:53:46Z | |
dc.date.available | 2017-06-07T06:53:46Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 2050-6406 | |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/330 | |
dc.description.abstract | BACKGROUND: There is little information about the fecal immunochemical test (FIT) in familial-risk colorectal cancer (CRC) screening. OBJECTIVES: The objective of this article is to investigate whether FIT diagnostic accuracy for advanced neoplasia (AN) differs between average and familial-risk (first-degree relative) patients. METHODS: A total of 1317 consecutive participants (595 familial) who collected one stool sample before performing a colonoscopy as a CRC screening test were included. FIT diagnostic accuracy for AN was evaluated with Chi-square test at a 20 microg hemoglobin/g of feces cut-off value. Finally, we determined which variables were independently related to AN. RESULTS: An AN was found in 151 (11.5%) patients. The overall accuracy was not statistically different between both cohorts for AN (88.4%, 91.7%; p = 0.051). At the cut-off stablished, differences in FIT sensitivity (31.1%, 40.6%; p = 0.2) or specificity (96.5%, 97.3%; p = 0.1) were not statistically significant. Finally, independent variables such as sex (male) (odds ratio (OR) 2.1, 95% confidence interval (CI) 1.4-3.1), age (50-65, >65 years) (OR 2.1, 95% CI 1.1-4.3; OR 2.7, 95% CI 1.2-6.1), previous colonoscopy (OR 0.4, 95% CI 0.2-0.9) and FIT >/=20 microg/g feces (OR 17.7, 95% CI 10.8-29.1) were associated with AN diagnosis. CONCLUSIONS: FIT accuracy for AN detection is equivalent in average and familial-risk CRC screening cohorts. | |
dc.language.iso | eng | |
dc.subject.mesh | Colorectal cancer | |
dc.title | Diagnostic accuracy of fecal immunochemical test in average- and familial-risk colorectal cancer screening | |
dc.type | Artigo | es |
dc.authorsophos | Cubiella, J. | |
dc.authorsophos | Castro, I. | |
dc.authorsophos | Hernandez, V. | |
dc.authorsophos | Gonzalez-Mao, C. | |
dc.authorsophos | Rivera, C. | |
dc.authorsophos | Iglesias, F. | |
dc.authorsophos | Alves, M. T. | |
dc.authorsophos | Cid, L. | |
dc.authorsophos | Soto, S. | |
dc.authorsophos | De-Castro, L. | |
dc.authorsophos | Vega, P. | |
dc.authorsophos | Hermo, J. A. | |
dc.authorsophos | Macenlle, R. | |
dc.authorsophos | Martinez, A. | |
dc.authorsophos | Estevez, P. | |
dc.authorsophos | Cid, E. | |
dc.authorsophos | Herreros-Villanueva, M. | |
dc.authorsophos | Portillo, I. | |
dc.authorsophos | Bujanda, L. | |
dc.authorsophos | Fernandez-Seara, J. | |
dc.identifier.doi | 10.1177/2050640614553285 | |
dc.identifier.isi | 347777400010 | |
dc.identifier.pmid | 25452848 | |
dc.identifier.sophos | 15881 | |
dc.issue.number | 6 | |
dc.journal.title | United European Gastroenterology Journal | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Ourense - Complexo Hospitalario Universitario de Ourense::Dixestivo | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Vigo - Complexo Hospitalario Universitario de Vigo::Análise clínicos | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Vigo - Complexo Hospitalario Universitario de Vigo::Dixestivo | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Vigo - Complexo Hospitalario Universitario de Vigo::Farmacia | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Vigo::IBI - Instituto de Investigación Biomédica de Ourense, Pontevedra y Vigo | |
dc.page.initial | 522 | |
dc.page.final | 9 | |
dc.rights.accessRights | openAccess | |
dc.typesophos | Artículo Original | |
dc.volume.number | 2 |
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