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dc.contributor.authorAlonso Pérez, Elisa
dc.contributor.authorSuarez Gestal, Marian
dc.contributor.authorCalaza Cabanas, Manuel
dc.contributor.authorWitte, Torsten
dc.contributor.authorPapasteriades, Chryssa
dc.contributor.authorMarchini, Maurizio
dc.contributor.authorMigliaresi, Sergio
dc.contributor.authorKovacs, Attila
dc.contributor.authorOrdi-Ros, Josep
dc.contributor.authorBijil, Marc
dc.contributor.authorSantos, María José
dc.contributor.authorRuzickova, Sarka
dc.contributor.authorPullman, Rudolf
dc.contributor.authorCarreira, Patricia
dc.contributor.authorSkopouli, Fotini N
dc.contributor.authorD´Alfonso, Sandra
dc.contributor.authorSebastiani, Gian Domenico
dc.contributor.authorSuarez, Ana
dc.contributor.authorBLANCO GARCIA, FRANCISCO JAVIER 
dc.contributor.authorGómez-Reino Carnota, Juan Jesús 
dc.contributor.authorGonzález Martínez-Pedrayo, Antonio 
dc.contributor.authorEuropean Consortium of SLE DNA Collections
dc.date.accessioned2017-06-07T07:10:30Z
dc.date.available2017-06-07T07:10:30Z
dc.date.issued2011
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/20.500.11940/3450
dc.description.abstractSystemic Lupus Erythematosus (SLE) is an autoimmune disease with a very varied spectrum of clinical manifestations that could be partly determined by genetic factors. We aimed to determine the relationship between prevalence of 11 clinical features and age of disease onset with European population genetic substructure. Data from 1413 patients of European ancestry recruited in nine countries was tested for association with genotypes of top ancestry informative markers. This analysis was done with logistic regression between phenotypes and genotypes or principal components extracted from them. We used a genetic additive model and adjusted for gender and disease duration. Three clinical features showed association with ancestry informative markers: autoantibody production defined as immunologic disorder (P = 6.8x10(-4)), oral ulcers (P = 6.9x10(-4)) and photosensitivity (P = 0.002). Immunologic disorder was associated with genotypes more common in Southern European ancestries, whereas the opposite trend was observed for photosensitivity. Oral ulcers were specifically more common in patients of Spanish and Portuguese self-reported ancestry. These results should be taken into account in future research and suggest new hypotheses and possible underlying mechanisms to be investigated. A first hypothesis linking photosensitivity with variation in skin pigmentation is suggested.
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleAssociation of systemic lupus erythematosus clinical features with European population genetic substructure.
dc.typeArtigoes
dc.authorsophosAlonso-Perez, Elisa
dc.authorsophosSuarez-Gestal, Marian
dc.authorsophosCalaza, Manuel
dc.authorsophosWitte, Torsten
dc.authorsophosPapasteriades, Chryssa
dc.authorsophosMarchini, Maurizio
dc.authorsophosMigliaresi, Sergio
dc.authorsophosKovacs, Attila
dc.authorsophosOrdi-Ros, Josep
dc.authorsophosBijl, Marc
dc.authorsophosSantos, Maria Jose
dc.authorsophosRuzickova, Sarka
dc.authorsophosPullmann, Rudolf
dc.authorsophosCarreira, Patricia
dc.authorsophosSkopouli, Fotini N
dc.authorsophosD'Alfonso, Sandra
dc.authorsophosSebastiani, Gian Domenico
dc.authorsophosSuarez, Ana
dc.authorsophosBlanco, Francisco J
dc.authorsophosGomez-Reino, Juan J
dc.authorsophosGonzalez, Antonio
dc.identifier.doi10.1371/journal.pone.0029033
dc.identifier.isi298369100145
dc.identifier.pmid22194982
dc.identifier.sophos9831
dc.issue.number12
dc.journal.titlePLoS One
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario A Coruña::Reumatoloxía
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago - Complexo Hospitalario Universitario de Santiago::Reumatoloxía
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago
dc.page.initiale29033
dc.page.finale29033
dc.rights.accessRightsopenAccess
dc.typesophosArtículo Original
dc.volume.number6


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