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dc.contributor.authorPena-Bello, L.
dc.contributor.authorPertega Diaz, Sonia 
dc.contributor.authorOuteiriño Blanco, Elena 
dc.contributor.authorGarcía Buela, Jesús 
dc.contributor.authorTovar Carro, Sulay
dc.contributor.authorSangiao Alvarellos, Susana
dc.contributor.authorDiéguez González, Carlos
dc.contributor.authorCordido Carballo, Fernando
dc.date.accessioned2017-06-07T07:10:46Z
dc.date.available2017-06-07T07:10:46Z
dc.date.issued2015
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/20.500.11940/3511
dc.description.abstractCONTEXT: Metabolic substrates and nutritional status play a major role in growth hormone (GH) secretion. Uncovering the mechanisms involved in GH secretion following oral glucose (OG) administration in normal and obese patients is a pending issue. OBJECTIVE: The aim of this study was to investigate GH after OG in relation with adiposity, insulin secretion and action, and ghrelin secretion in obese and healthy women, to further elucidate the mechanism of GH secretion after OG and the altered GH secretion in obesity. PARTICIPANTS AND METHODS: We included 64 healthy and obese women. After an overnight fast, 75 g of OG were administered; GH, glucose, insulin and ghrelin were obtained during 300 minutes. Insulin secretion and action indices and the area under the curve (AUC) were calculated for GH, glucose, insulin and ghrelin. Univariate and multivariate linear regression analyses were employed. RESULTS: The AUC of GH (mug/L*min) was lower in obese (249.8+/-41.8) than in healthy women (490.4+/-74.6), P=0.001. The AUC of total ghrelin (pg/mL*min) was lower in obese (240995.5+/-11094.2) than in healthy women (340797.5+/-37757.5), P=0.042. There were significant correlations between GH secretion and the different adiposity, insulin secretion and action, and ghrelin secretion indices. After multivariate analysis only ghrelin AUC remained a significant predictor for fasting and peak GH.
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshAdiposity
dc.subject.meshAdult
dc.subject.meshFemale
dc.subject.meshGhrelin
dc.subject.meshHuman Growth Hormone
dc.subject.meshHumans
dc.subject.meshInsulin Resistance
dc.subject.meshObesity
dc.titleEffect of oral glucose administration on rebound growth hormone release in normal and obese women: the role of adiposity, insulin sensitivity and ghrelin
dc.typeArtigoes
dc.authorsophosPena-Bello, L.
dc.authorsophosPertega-Diaz, S.
dc.authorsophosOuteirino-Blanco, E.
dc.authorsophosGarcia-Buela, J.
dc.authorsophosTovar, S.
dc.authorsophosSangiao-Alvarellos, S.
dc.authorsophosDieguez, C.
dc.authorsophosCordido, F.
dc.identifier.doi10.1371/journal.pone.0121087
dc.identifier.pmid25782001
dc.identifier.sophos18183
dc.issue.number3
dc.journal.titlePLoS One
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario A Coruña::Endocrinoloxía
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario A Coruña::Epidemioloxía
dc.page.initiale0121087
dc.rights.accessRightsopenAccess
dc.typesophosArtículo Original
dc.volume.number10


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