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dc.contributor.authorKerns, S. L.
dc.contributor.authorStock, R. G.
dc.contributor.authorStone, N. N.
dc.contributor.authorBlacksburg, S. R.
dc.contributor.authorRath, L.
dc.contributor.authorVega Gliemmo, Ana
dc.contributor.authorFachal Vilar, Laura
dc.contributor.authorGómez Caamaño, Antonio 
dc.contributor.authorDe Ruysscher, D.
dc.contributor.authorLammering, G.
dc.contributor.authorParliament, M.
dc.contributor.authorBlackshaw, M.
dc.contributor.authorSia, M.
dc.contributor.authorCesaretti, J.
dc.contributor.authorTerk, M.
dc.contributor.authorHixson, R.
dc.contributor.authorRosenstein, B. S.
dc.contributor.authorOstrer, H.
dc.date.accessioned2017-06-07T07:11:01Z
dc.date.available2017-06-07T07:11:01Z
dc.date.issued2013
dc.identifier.issn0167-8140
dc.identifier.urihttp://hdl.handle.net/20.500.11940/3558
dc.description.abstractBACKGROUND AND PURPOSE: Rectal bleeding can occur following radiotherapy for prostate cancer and negatively impacts quality of life for cancer survivors. Treatment and clinical factors do not fully predict rectal bleeding, and genetic factors may be important. MATERIALS AND METHODS: A genome-wide association study (GWAS) was performed to identify SNPs associated with the development of late rectal bleeding following radiotherapy for prostate cancer. Logistic regression was used to test the association between 614,453 SNPs and rectal bleeding in a discovery cohort (79 cases, 289 controls), and top-ranking SNPs were tested in a replication cohort (108 cases, 673 controls) from four independent sites. RESULTS: rs7120482 and rs17630638, which tag a single locus on chromosome 11q14.3, reached genome-wide significance for association with rectal bleeding (combined p-values 5.4x10(-8) and 6.9x10(-7) respectively). Several other SNPs had p-values trending toward genome-wide significance, and a polygenic risk score including these SNPs shows a strong rank-correlation with rectal bleeding (Sommers' d=5.0x10(-12) in the replication cohort). CONCLUSIONS: This GWAS identified novel genetic markers of rectal bleeding following prostate radiotherapy. These findings could lead to the development of a predictive assay to identify patients at risk for this adverse treatment outcome so that dose or treatment modality could be modified.
dc.language.isoeng
dc.subject.meshAged
dc.subject.meshChromosomes, Human, Pair 11
dc.subject.meshGastrointestinal Hemorrhage
dc.subject.meshGenome-Wide Association Study
dc.subject.meshHumans
dc.subject.meshLogistic Models
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshProstatic Neoplasms
dc.subject.meshRectal Diseases
dc.subject.meshGenome-wide association study
dc.subject.meshProstate cancer
dc.subject.meshRadiogenomics
dc.subject.meshRectal toxicity
dc.titleGenome-wide association study identifies a region on chromosome 11q14.3 associated with late rectal bleeding following radiation therapy for prostate cancer
dc.typeArtigoes
dc.authorsophosKerns, S. L.
dc.authorsophosStock, R. G.
dc.authorsophosStone, N. N.
dc.authorsophosBlacksburg, S. R.
dc.authorsophosRath, L.
dc.authorsophosVega, A.
dc.authorsophosFachal, L.
dc.authorsophosGómez-Caamaño, A.
dc.authorsophosDe Ruysscher, D.
dc.authorsophosLammering, G.
dc.authorsophosParliament, M.
dc.authorsophosBlackshaw, M.
dc.authorsophosSia, M.
dc.authorsophosCesaretti, J.
dc.authorsophosTerk, M.
dc.authorsophosHixson, R.
dc.authorsophosRosenstein, B. S.
dc.authorsophosOstrer, H.
dc.identifier.doi10.1016/j.radonc.2013.05.001
dc.identifier.isi323869100018
dc.identifier.pmid23719583
dc.identifier.sophos13300
dc.issue.number3
dc.journal.titleRADIOTHERAPY AND ONCOLOGY
dc.organizationConsellería de Sanidade::Fundación pública Galega de Medicina Xenómica
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago - Complexo Hospitalario Universitario de Santiago::Oncología Radioterápica
dc.page.initial372
dc.page.final376
dc.relation.publisherversionhttp://europepmc.org/articles/pmc3787843?pdf=render
dc.rights.accessRightsopenAccess
dc.typesophosArtículo Original
dc.volume.number107


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