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dc.contributor.authorMarcos-Villar, Laura
dc.contributor.authorPérez-Girón, José
dc.contributor.authorVilas Martínez, Jessica María
dc.contributor.authorSoto Simón, Atenea
dc.contributor.authorde la Cruz-Herrera, Carlos
dc.contributor.authorLang, Valerie
dc.contributor.authorCollado Rodríguez, Manuel
dc.contributor.authorVidal Figueroa, Anxo
dc.contributor.authorRodríguez, Manuel
dc.contributor.authorMuñoz-Fontela, Cesar
dc.contributor.authorRivas ?, Carmen
dc.date.accessioned2017-06-07T07:11:29Z
dc.date.available2017-06-07T07:11:29Z
dc.date.issued2013
dc.identifier.issn1538-4101
dc.identifier.urihttp://hdl.handle.net/20.500.11940/3634
dc.description.abstractThere is growing evidence that many host proteins involved in innate and intrinsic immunity are regulated by SUMOylation, and that SUMO contributes to the regulatory process that governs the initiation of the type I interferon (IFN) response. The tumor suppressor p53 is a modulator of the IFN response that plays a role in virus-induced apoptosis and in IFN-induced senescence. Here we demonstrate that IFN treatment increases the levels of SUMOylated p53 and induces cellular senescence through a process that is partially dependent upon SUMOylation of p53. Similarly, we show that vesicular stomatitis virus (VSV) infection induces p53 SUMOylation, and that this modification favors the control of VSV replication. Thus, our study provides evidence that IFN signaling induces p53 SUMOylation, which results in the activation of a cellular senescence program and contributes to the antiviral functions of interferon.
dc.language.isoeng
dc.subject.meshAntiviral Agents
dc.subject.meshInterferon-alpha
dc.titleSUMOylation of p53 mediates interferon activities
dc.typeArtigoes
dc.authorsophosMarcos-Villar, L.
dc.authorsophosPérez-Girón, J. V.
dc.authorsophosVilas, J. M.
dc.authorsophosSoto, A.
dc.authorsophosDe La Cruz-Herrera, C. F.
dc.authorsophosLang, V.
dc.authorsophosCollado, M.
dc.authorsophosVidal, A.
dc.authorsophosRodríguez, M. S.
dc.authorsophosMuñoz-Fontela, C.
dc.authorsophosRivas, C.
dc.identifier.doi10.4161/cc.25868
dc.identifier.isi327436300019
dc.identifier.pmid23966171
dc.identifier.sophos13434
dc.issue.number17
dc.journal.titleCELL CYCLE
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago
dc.page.initial2809
dc.page.final2816
dc.rights.accessRightsopenAccess
dc.subject.decsAntivirales
dc.subject.decsInterferón-alfa
dc.typesophosArtículo Original
dc.volume.number12


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