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dc.contributor.authorAguiar Fernández, Pablo
dc.contributor.authorPino, F
dc.contributor.authorSilva Rodríguez, Jesús
dc.contributor.authorPavía, J
dc.contributor.authorRos, D
dc.contributor.authorRuibal Morell, Alvaro 
dc.contributor.authorEl Bitar, Z
dc.date.accessioned2017-06-07T07:15:46Z
dc.date.available2017-06-07T07:15:46Z
dc.date.issued2014
dc.identifier.issn0094-2405
dc.identifier.urihttp://hdl.handle.net/20.500.11940/4474
dc.description.abstractPurpose: To assess the performance of two approaches to the system response matrix (SRM) calculation in pinhole single photon emission computed tomography (SPECT) reconstruction. Methods: Evaluation was performed using experimental data from a low magnification pinhole SPECT system that consisted of a rotating flat detector with a monolithic scintillator crystal. The SRM was computed following two approaches, which were based on Monte Carlo simulations (MC-SRM) and analytical techniques in combination with an experimental characterization (AE-SRM). The spatial response of the system, obtained by using the two approaches, was compared with experimental data. The effect of the MC-SRM and AE-SRM approaches on the reconstructed image was assessed in terms of image contrast, signal-to-noise ratio, image quality, and spatial resolution. To this end, acquisitions were carried out using a hot cylinder phantom (consisting of five fillable rods with diameters of 5, 4, 3, 2, and 1 mm and a uniform cylindrical chamber) and a custom-made Derenzo phantom, with center-to-center distances between adjacent rods of 1.5, 2.0, and 3.0 mm. Results: Good agreement was found for the spatial response of the system between measured data and results derived from MC-SRM and AE-SRM. Only minor differences for point sources at distances smaller than the radius of rotation and large incidence angles were found. Assessment of the effect on the reconstructed image showed a similar contrast for both approaches, with values higher than 0.9 for rod diameters greater than 1 mm and higher than 0.8 for rod diameter of 1 mm. The comparison in terms of image quality showed that all rods in the different sections of a custom-made Derenzo phantom could be distinguished. The spatial resolution (FWHM) was 0.7 mm at iteration 100 using both approaches. The SNR was lower for reconstructed images using MC-SRM than for those reconstructed using AE-SRM, indicating that AE-SRM deals better with the projection noise than MC-SRM. Conclusions: The authors' findings show that both approaches provide good solutions to the problem of calculating the SRM in pinhole SPECT reconstruction. The AE-SRM was faster to create and handle the projection noise better than MC-SRM. Nevertheless, the AE-SRM required a tedious experimental characterization of the intrinsic detector response. Creation of the MC-SRM required longer computation time and handled the projection noise worse than the AE-SRM.Nevertheless, the MC-SRM inherently incorporates extensive modeling of the system and therefore experimental characterization was not required.
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshAlgorithms 
dc.subject.meshComputer Simulation 
dc.subject.meshMonte Carlo Method 
dc.subject.meshTomography, Emission-Computed, Single-Photon 
dc.titleAnalytical, experimental, and Monte Carlo system response matrix for pinhole SPECT reconstruction
dc.typeArtigoes
dc.authorsophosAguiar, P.
dc.authorsophosPino, F.
dc.authorsophosSilva-Rodríguez, J.
dc.authorsophosPavía, J.
dc.authorsophosRos, D.
dc.authorsophosRuibal, A.
dc.authorsophosEl Bitar, Z.
dc.identifier.doi10.1118/1.4866380
dc.identifier.isi332485600037
dc.identifier.pmid24593739
dc.identifier.sophos14541
dc.issue.number3
dc.journal.titleMEDICAL PHYSICS
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago::Fundación Ramón Domínguez
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago - Complexo Hospitalario Universitario de Santiago::Medicina nuclear
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago
dc.page.initial32501
dc.rights.accessRightsopenAccess
dc.subject.decsAlgoritmos 
dc.subject.decsSimulación por Computador
dc.subject.decsMétodo de Montecarlo
dc.subject.decsTomografía Computarizada de Emisión de Fotón Único
dc.typesophosArtículo Original
dc.volume.number41


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