Regulatory T cells modulate inflammation and reduce infarct volume in experimental brain ischaemia
![Thumbnail](/xmlui/themes/Mirage2//images/thumbnails/thumn_cientif.png)
Identificadores![](/xmlui/themes/Mirage2//images/despl_identif.png)
Identificadores
Visualización o descarga de ficheros![](/xmlui/themes/Mirage2//images/despl_contenidos.png)
Visualización o descarga de ficheros
Fecha de publicación
2014Título de revista
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Tipo de contenido
Artigo
DeCS
Isquemia Encefálica | Infarto de la Arteria Cerebral Media | Inflamación | Neovascularización Patológica | Células-Madre Neurales | Accidente CerebrovascularMeSH
Brain Ischemia | Infarction, Middle Cerebral Artery | Inflammation | Neovascularization, Pathologic | Neural Stem Cells | Stroke | T-Lymphocytes, Regulatory | Linfocitos T ReguladoresResumen
Brain ischaemia (stroke) triggers an intense inflammatory response predominately mediated by the accumulation of inflammatory cells and mediators in the ischaemic brain. In this context, regulatory T (Treg) cells, a subpopulation of CD4(+) T cells with immunosuppressive and anti-inflammatory properties, are activated in the late stages of the disease. To date, the potential therapeutic usefulness of Treg cells has not been tested. In this study, we aimed to investigate whether Treg cells exert protection/repair following stroke. Both the adoptive transfer of Treg cells into ischaemic rats and the stimulation of endogenous T-cell proliferation using a CD28 superagonist reduced the infarct size at 3-28 days following the ischaemic insult. Moreover, T cell-treated animals had higher levels of FoxP3 and lower levels of IL-1β, CD11b+ and CD68+ cells in the infarcted hemisphere when compared with control animals. However, T-cell treatment did not alter the rate of proliferation of NeuN-, NCAM- or CD31-positive cells, thereby ruling out neurogenesis and angiogenesis in protection. These results suggest that adoptive transfer of T cells is a promising therapeutic strategy against the neurological consequences of stroke.
![](/xmlui/themes/Mirage2//images/final_lines.png)