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dc.contributor.authorBueno, C.
dc.contributor.authorRoldan, M.
dc.contributor.authorAnguita, E.
dc.contributor.authorRomero-Moya, D.
dc.contributor.authorMartín-Antonio, B.
dc.contributor.authorRosu-Myles, M.
dc.contributor.authordel Cañizo, C.
dc.contributor.authorCampos Pérez, Francisco 
dc.contributor.authorGarcía, R.
dc.contributor.authorGómez-Casares, M.
dc.contributor.authorFuster, J. L.
dc.contributor.authorJurado, M.
dc.contributor.authorDelgado, M.
dc.contributor.authorMenendez, P.
dc.date.accessioned2017-06-07T07:16:01Z
dc.date.available2017-06-07T07:16:01Z
dc.date.issued2014
dc.identifier.issn0390-6078
dc.identifier.urihttp://hdl.handle.net/20.500.11940/4518
dc.description.abstractAplastic anemia is a life-threatening bone marrow failure disorder characterized by peripheral pancytopenia and marrow hypoplasia. The majority of cases of aplastic anemia remain idiopathic, although hematopoietic stem cell deficiency and impaired immune responses are hallmarks underlying the bone marrow failure in this condition. Mesenchymal stem/stromal cells constitute an essential component of the bone marrow hematopoietic microenvironment because of their immunomodulatory properties and their ability to support hematopoiesis, and they have been involved in the pathogenesis of several hematologic malignancies. We investigated whether bone marrow mesenchymal stem cells contribute, directly or indirectly, to the pathogenesis of aplastic anemia. We found that mesenchymal stem cell cultures can be established from the bone marrow of aplastic anemia patients and display the same phenotype and differentiation potential as their counterparts from normal bone marrow. Mesenchymal stem cells from aplastic anemia patients support the in vitro homeostasis and the in vivo repopulating function of CD34(+) cells, and maintain their immunosuppressive and anti-inflammatory properties. These data demonstrate that bone marrow mesenchymal stem cells from patients with aplastic anemia do not have impaired functional and immunological properties, suggesting that they do not contribute to the pathogenesis of the disease.
dc.language.isoeng
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAnemia, Aplastic
dc.subject.meshAntigens, CD34
dc.subject.meshCase-Control Studies
dc.subject.meshCell Differentiation
dc.subject.meshCells, Cultured
dc.subject.meshChild
dc.subject.meshCoculture Techniques
dc.subject.meshFemale
dc.subject.meshFetal Blood
dc.subject.meshGraft Survival
dc.subject.meshHematopoietic Stem Cell Transplantation
dc.subject.meshHematopoietic Stem
dc.subject.meshHumans
dc.subject.meshImmunomodulation
dc.subject.meshImmunophenotyping
dc.subject.meshMale
dc.subject.meshMesenchymal Stem Cells
dc.subject.meshMiddle Aged
dc.subject.meshPhenotype
dc.subject.meshYoung Adult
dc.titleBone marrow mesenchymal stem cells from patients with aplastic anemia maintain functional and immune properties and do not contribute to the pathogenesis of the disease
dc.typeArtigoes
dc.authorsophosBueno, C.
dc.authorsophosRoldan, M.
dc.authorsophosAnguita, E.
dc.authorsophosRomero-Moya, D.
dc.authorsophosMartín-Antonio, B.
dc.authorsophosRosu-Myles, M.
dc.authorsophosdel Cañizo, C.
dc.authorsophosCampos, F.
dc.authorsophosGarcía, R.
dc.authorsophosGómez-Casares, M.
dc.authorsophosFuster, J. L.
dc.authorsophosJurado, M.
dc.authorsophosDelgado, M.
dc.authorsophosMenendez, P.
dc.identifier.doi10.3324/haematol.2014.103580
dc.identifier.pmid24727813
dc.identifier.sophos14585
dc.issue.number7
dc.journal.titleHaematologica
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago - Complexo Hospitalario Universitario de Santiago::Neuroloxía
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago
dc.page.initial1168
dc.page.final75
dc.rights.accessRightsopenAccess
dc.typesophosArtículo Original
dc.volume.number99


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