No association between typical European mitochondrial variation and prostate cancer risk in a Spanish cohort
dc.contributor.author | Fachal Vilar, Laura | |
dc.contributor.author | Gómez Caamaño, Antonio | |
dc.contributor.author | Alvarez Iglesias, V. | |
dc.contributor.author | Gómez Carballa, A. | |
dc.contributor.author | Calvo Crespo, Patricia | |
dc.contributor.author | Salas, A. | |
dc.contributor.author | Vega Gliemmo, Ana | |
dc.date.accessioned | 2017-06-07T07:16:22Z | |
dc.date.available | 2017-06-07T07:16:22Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1434-5161 | |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/4580 | |
dc.description.abstract | Mitochondrial common variants (mtSNPs) and the haplogroups defined by them have been inconsistently correlated with increased prostate cancer risk. Here we aimed to investigate the influence of the mitochondrial genetic background on prostate cancer. A total of 15 single-nucleotide polymorphisms (SNPs) representing the common European branches of the mtDNA phylogeny were analyzed in a cohort of 620 Spanish prostate cancer patients and 616 matched population-based controls. Association tests were computed on mtSNPs and haplogroups. None of the evaluated mtSNPs or haplogroups were statistically associated with prostate cancer risk in our Spanish cohort. We show that previous association findings do not rest on solid grounds given that all of them (i) were based on underpowered studies, (ii) did not control for population stratification, (iii) lacked replication/confirmation cohorts, and (iv) and did not control for multiple test corrections. Taken together, a critical reassessment of the previous literature and the results obtained in the present study suggest that mtDNA common European variants are not correlated with increases in the risk for prostate cancer. | |
dc.language.iso | eng | |
dc.subject.mesh | Aged | |
dc.subject.mesh | Aged, 80 and over | |
dc.subject.mesh | Alleles | |
dc.subject.mesh | Case-Control Studies | |
dc.subject.mesh | Cohort Studies | |
dc.subject.mesh | DNA, Mitochondrial | |
dc.subject.mesh | European Continental Ancestry Group | |
dc.subject.mesh | Gene Frequency | |
dc.subject.mesh | Genetic Predisposition to Disease | |
dc.subject.mesh | Genetic Variation | |
dc.subject.mesh | Genotype | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Male | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Neoplasm Grading | |
dc.subject.mesh | Neoplasm Staging | |
dc.subject.mesh | Odds Ratio | |
dc.subject.mesh | Polymorphism, Single Nucleotide | |
dc.subject.mesh | Prostatic Neoplasms | |
dc.subject.mesh | Spain | |
dc.title | No association between typical European mitochondrial variation and prostate cancer risk in a Spanish cohort | |
dc.type | Artigo | es |
dc.authorsophos | Fachal, L. | |
dc.authorsophos | Gómez-Caamaño, A. | |
dc.authorsophos | Alvarez Iglesias, V. | |
dc.authorsophos | Gómez Carballa, A. | |
dc.authorsophos | Calvo, P. | |
dc.authorsophos | Salas, A. | |
dc.authorsophos | Vega, A. | |
dc.identifier.doi | 10.1038/jhg.2014.46 | |
dc.identifier.isi | 344536100010 | |
dc.identifier.pmid | 24898828 | |
dc.identifier.sophos | 14648 | |
dc.issue.number | 7 | |
dc.journal.title | JOURNAL OF HUMAN GENETICS | |
dc.organization | Consellería de Sanidade::Fundación pública Galega de Medicina Xenómica | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago | |
dc.page.initial | 411 | |
dc.page.final | 4 | |
dc.rights.accessRights | openAccess | |
dc.typesophos | Artículo de Opinión | |
dc.volume.number | 59 |