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dc.contributor.authorFachal Vilar, Laura
dc.contributor.authorGómez Caamaño, Antonio 
dc.contributor.authorAlvarez Iglesias, V.
dc.contributor.authorGómez Carballa, A.
dc.contributor.authorCalvo Crespo, Patricia 
dc.contributor.authorSalas, A.
dc.contributor.authorVega Gliemmo, Ana
dc.date.accessioned2017-06-07T07:16:22Z
dc.date.available2017-06-07T07:16:22Z
dc.date.issued2014
dc.identifier.issn1434-5161
dc.identifier.urihttp://hdl.handle.net/20.500.11940/4580
dc.description.abstractMitochondrial common variants (mtSNPs) and the haplogroups defined by them have been inconsistently correlated with increased prostate cancer risk. Here we aimed to investigate the influence of the mitochondrial genetic background on prostate cancer. A total of 15 single-nucleotide polymorphisms (SNPs) representing the common European branches of the mtDNA phylogeny were analyzed in a cohort of 620 Spanish prostate cancer patients and 616 matched population-based controls. Association tests were computed on mtSNPs and haplogroups. None of the evaluated mtSNPs or haplogroups were statistically associated with prostate cancer risk in our Spanish cohort. We show that previous association findings do not rest on solid grounds given that all of them (i) were based on underpowered studies, (ii) did not control for population stratification, (iii) lacked replication/confirmation cohorts, and (iv) and did not control for multiple test corrections. Taken together, a critical reassessment of the previous literature and the results obtained in the present study suggest that mtDNA common European variants are not correlated with increases in the risk for prostate cancer.
dc.language.isoeng
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshAlleles
dc.subject.meshCase-Control Studies
dc.subject.meshCohort Studies
dc.subject.meshDNA, Mitochondrial
dc.subject.meshEuropean Continental Ancestry Group
dc.subject.meshGene Frequency
dc.subject.meshGenetic Predisposition to Disease
dc.subject.meshGenetic Variation
dc.subject.meshGenotype
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNeoplasm Grading
dc.subject.meshNeoplasm Staging
dc.subject.meshOdds Ratio
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshProstatic Neoplasms
dc.subject.meshSpain
dc.titleNo association between typical European mitochondrial variation and prostate cancer risk in a Spanish cohort
dc.typeArtigoes
dc.authorsophosFachal, L.
dc.authorsophosGómez-Caamaño, A.
dc.authorsophosAlvarez Iglesias, V.
dc.authorsophosGómez Carballa, A.
dc.authorsophosCalvo, P.
dc.authorsophosSalas, A.
dc.authorsophosVega, A.
dc.identifier.doi10.1038/jhg.2014.46
dc.identifier.isi344536100010
dc.identifier.pmid24898828
dc.identifier.sophos14648
dc.issue.number7
dc.journal.titleJOURNAL OF HUMAN GENETICS
dc.organizationConsellería de Sanidade::Fundación pública Galega de Medicina Xenómica
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago
dc.page.initial411
dc.page.final4
dc.rights.accessRightsopenAccess
dc.typesophosArtículo de Opinión
dc.volume.number59


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