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Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

dc.contributor.authorOrr, N.
dc.contributor.authorLemnrau, A.
dc.contributor.authorCooke, R.
dc.contributor.authorFletcher, O.
dc.contributor.authorTomczyk, K.
dc.contributor.authorJones, M.
dc.contributor.authorJohnson, N.
dc.contributor.authorLord, C. J.
dc.contributor.authorMitsopoulos, C
dc.contributor.authorZvelebil, M.
dc.contributor.authorMcDade, S. S.
dc.contributor.authorBuck, G.
dc.contributor.authorBlancher, C.
dc.contributor.authorTrainer, A. H.
dc.contributor.authorJames, P. A.
dc.contributor.authorBojesen, S. E.
dc.contributor.authorBokm, , S.
dc.contributor.authorNevanlinna, H.
dc.contributor.authorMattson, J.
dc.contributor.authorFriedman, E
dc.contributor.authorLaitman, Y.
dc.contributor.authorPalli, D.
dc.contributor.authorMasala, G.
dc.contributor.authorZanna, I.
dc.contributor.authorOttini, L.
dc.contributor.authorGiannini, G.
dc.contributor.authorHollestelle, A.
dc.contributor.authorVan Den Ouwel, , A. M. W.
dc.contributor.authorNovaković, S.
dc.contributor.authorKrajc, M.
dc.contributor.authorGago Dominguez, Manuela
dc.contributor.authorCastelao Fernández, José Esteban 
dc.contributor.authorOlsson, H.
dc.contributor.authorHedenfalk, I.
dc.contributor.authorEaston, D. F.
dc.contributor.authorPharoah, P. D. P.
dc.contributor.authorDunning, A. M.
dc.contributor.authorBishop, D. T.
dc.contributor.authorNeuhausen, S. L.
dc.contributor.authorSteele, L.
dc.contributor.authorHoulston, R. S.
dc.contributor.authorGarcia-Closas, M.
dc.contributor.authorAshworth, A.
dc.contributor.authorSwerdlow, A. J.
dc.date.accessioned2017-06-07T06:55:09Z
dc.date.available2017-06-07T06:55:09Z
dc.date.issued2012
dc.identifier.issn1061-4036
dc.identifier.urihttp://hdl.handle.net/20.500.11940/571
dc.description.abstractWe conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 × 10-13; odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 × 10-15; OR = 1.50).
dc.description.sponsorshipInstituto de Salud Carlos III/Programa Grupos Emergentes
dc.language.isoeng
dc.subject.meshBreast Neoplasms, Male
dc.subject.meshChromosomes, Human, Pair 14
dc.subject.meshDNA-Binding Proteins
dc.subject.meshEuropean Continental Ancestry Group
dc.subject.meshGenetic Predisposition to Disease
dc.subject.meshGenome-Wide Association Study
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshRisk Factors
dc.titleGenome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk
dc.typeArtigoes
dc.authorsophosOrr, N.
dc.authorsophosLemnrau, A.
dc.authorsophosCooke, R.
dc.authorsophosFletcher, O.
dc.authorsophosTomczyk, K.
dc.authorsophosJones, M.
dc.authorsophosJohnson, N.
dc.authorsophosLord, C. J.
dc.authorsophosMitsopoulos, C.
dc.authorsophosZvelebil, M.
dc.authorsophosMcDade, S. S.
dc.authorsophosBuck, G.
dc.authorsophosBlancher, C.
dc.authorsophosTrainer, A. H
dc.authorsophosJames, P. A.
dc.authorsophosBojesen, S. E.
dc.authorsophosBokm, , S.
dc.authorsophosNevanlinna, H.
dc.authorsophosMattson, J.
dc.authorsophosFriedman, E.
dc.authorsophosLaitman, Y.
dc.authorsophosPalli, D.
dc.authorsophosMasala, G.
dc.authorsophosZanna, I.
dc.authorsophosOttini, L.
dc.authorsophosGiannini, G.
dc.authorsophosHollestelle, A.
dc.authorsophosVan Den Ouwel, , A. M. W.
dc.authorsophosNovaković, S.
dc.authorsophosKrajc, M.
dc.authorsophosGago-Dominguez, M.
dc.authorsophosCastelao, J.
dc.authorsophosOlsson, H.
dc.authorsophosHedenfalk, I.
dc.authorsophosEaston, D. F.
dc.authorsophosPharoah, P. D. P.
dc.authorsophosDunning, A. M.
dc.authorsophosBishop, D. T.
dc.authorsophosNeuhausen, S. L.
dc.authorsophosSteele, L.
dc.authorsophosHoulston, R. S.
dc.authorsophosGarcia-Closas, M.
dc.authorsophosAshworth, A.
dc.authorsophosSwerdlow, A. J.
dc.identifier.doi10.1038/ng.2417
dc.identifier.isi310495800006
dc.identifier.pmid23001122
dc.identifier.sophos12877
dc.issue.number11
dc.journal.titleNATURE GENETICS
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Vigo::IBI - Instituto de Investigación Biomédica de Ourense, Pontevedra y Vigo::Fundación Biomédica del Complexo Hospitalario Universitario de Vigo
dc.rights.accessRightsopenAccess
dc.subject.decsNeoplasias de la Mama Masculina
dc.subject.decsDNA-Binding Proteins
dc.subject.decsProteínas de Unión al ADN
dc.subject.decsEstudio de Asociación del Genoma Completo
dc.typesophosArtículo Original
dc.volume.number44


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Nat Genet . 2012 Nov;44(11):1182-4

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