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The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis

dc.contributor.authorGarcia, S.
dc.contributor.authorConde Muro, Carmen 
dc.date.accessioned2017-06-07T07:27:57Z
dc.date.available2017-06-07T07:27:57Z
dc.date.issued2015
dc.identifier.issn0962-9351
dc.identifier.urihttp://hdl.handle.net/20.500.11940/6777
dc.description.abstractPoly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme with a crucial role in the maintenance of genomic stability. In addition to the role of PARP-1 in DNA repair, multiple studies have also demonstrated its involvement in several inflammatory diseases, such as septic shock, asthma, atherosclerosis, and stroke, as well as in cancer. In these diseases, the pharmacological inhibition of PARP-1 has shown a beneficial effect, suggesting that PARP-1 regulates their inflammatory processes. In recent years, we have studied the role of PARP-1 in rheumatoid arthritis, as have other researchers, and the results have shown that PARP-1 has an important function in the development of this disease. This review summarizes current knowledge on the effects of PARP-1 in rheumatoid arthritis.
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshAnimals
dc.subject.meshArthritis, Rheumatoid
dc.subject.meshHumans
dc.subject.meshInflammation
dc.subject.meshPoly (ADP-Ribose) Polymerase-1
dc.subject.meshPoly(ADP-ribose) Polymerases
dc.titleThe Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis
dc.typeArtigoes
dc.authorsophosGarcia, S.
dc.authorsophosConde, C.
dc.identifier.doi10.1155/2015/837250
dc.identifier.isi359579900001
dc.identifier.sophos18630
dc.issue.number837250
dc.journal.titleMEDIATORS OF INFLAMMATION
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago - Complexo Hospitalario Universitario de Santiago::Unidad de Investigación
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago
dc.page.initial837250
dc.rights.accessRightsopenAccess
dc.typesophosArtículo de Revisión
dc.volume.number2015


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Mediators of inflammation. 2015;(837250):837250. DOI. 10.1155/2015/837250

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