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dc.contributor.authorBordón, J
dc.contributor.authorKapoor, R
dc.contributor.authorMartinez Vázquez, Cesar Antonio 
dc.contributor.authorPORTELA ORJALES, DANIEL 
dc.contributor.authorBuvvuri, P
dc.contributor.authorKlochko, A
dc.contributor.authorAyesu, K
dc.contributor.authorPeyrani, P
dc.contributor.authorCillóniz C
dc.contributor.authorWiemken, T
dc.contributor.authorParra, A
dc.contributor.authorTorres, A
dc.contributor.authorRello, J
dc.contributor.authorRamírez, J
dc.date.accessioned2017-06-07T07:28:42Z
dc.date.available2017-06-07T07:28:42Z
dc.date.issued2011
dc.identifier.issn1201-9712
dc.identifier.urihttp://hdl.handle.net/20.500.11940/6952
dc.description.abstractOutcomes of community-acquired pneumonia (CAP) in relation to CD4+ cell counts have not been established. We examined the correlation of CD4+ cell count and HIV-RNA level with the clinical outcomes of CAP in hospitalized HIV-infected patients. METHODS: This was a retrospective study of 127 adult hospitalized patients with HIV infection enrolled with the CAP Organization (CAPO), examining the time to clinical stability (TCS), length of hospital stay (LOS), and all-cause mortality. RESULTS: Mortality data were available for 117 HIV-infected patients with CAP. Death within 28 days was reported in 28 patients. The risk of mortality at 28 days was not significant when adjusted for CD4+ cell count (p=0.123), HIV-RNA <400-1000 copies/ml (p=0.093), HIV-RNA ≥ 1000-10,000 copies/ml (p=0.543), and HIV-RNA ≥ 10,000-100,000 copies/ml (p=0.383). The propensity-adjusted Cox proportional hazards regression models did not show any statistically significant differences in LOS or TCS for CD4+ cell counts (p=0.590 and p=0.420, respectively) or HIV-RNA levels (p=0.470 and p=0.080, respectively). Multivariable Cox proportional hazards models did not reveal any statistically significant relationships between CD4+ cell counts or HIV-RNA levels with LOS or TCS. CONCLUSIONS: Our study shows that clinical outcomes of HIV-infected patients with CAP are not predicted by CD4+ cell counts or HIV-RNA levels after adjusting for confounders. The management of CAP in patients with HIV infection should not be based on CD4+ cell counts or HIV-RNA levels of the HIV infection.
dc.language.isoeng
dc.subject.meshCD4 Lymphocyte Count
dc.subject.meshKaplan-Meier Estimate
dc.subject.meshLength of Stay
dc.subject.meshPneumonia, Bacterial
dc.subject.meshProportional Hazards Models
dc.subject.meshRNA, Viral
dc.subject.meshSpain
dc.subject.meshRetrospective Studies
dc.subject.meshDrug Therapy, Combination
dc.subject.meshCohort Studies
dc.titleCD4+ cell counts and HIV-RNA levels do not predict outcomes of community-acquired pneumonia in hospitalized HIV-infected patients
dc.typeArtigoes
dc.authorsophosBordon, J.
dc.authorsophosKapoor, R.
dc.authorsophosMartinez, C.
dc.authorsophosPortela, D.
dc.authorsophosDuvvuri, P.
dc.authorsophosKlochko, A.
dc.authorsophosAyesu, K.
dc.authorsophosPeyrani, P.
dc.authorsophosCillóniz, C.
dc.authorsophosWiemken, T.
dc.authorsophosParra, A.
dc.authorsophosTorres, A.
dc.authorsophosRello, J.
dc.authorsophosRamirez, J.
dc.identifier.doi10.1016/j.ijid.2011.05.021
dc.identifier.isi298114700004
dc.identifier.pmid21885316
dc.identifier.sophos12914
dc.issue.number12
dc.journal.titleINTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Vigo - Complexo Hospitalario Universitario de Vigo::Medicina Interna
dc.rights.accessRightsopenAccess
dc.typesophosArtículo Original
dc.volume.number15


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