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Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis.

dc.contributor.authorTeruel, María
dc.contributor.authorSimeon, Carmen P
dc.contributor.authorBroen, Jasper
dc.contributor.authorVonk, Madelon C
dc.contributor.authorCarreira, Patricia
dc.contributor.authorCamps, Maria Teresa
dc.contributor.authorGarcía-Portales, Rosa
dc.contributor.authorDelgado-Frías, Esmeralda
dc.contributor.authorGallego, Maria
dc.contributor.authorEspinosa, Gerard
dc.contributor.authorSpanish Scleroderma Group
dc.contributor.authorBeretta, Lorenzo
dc.contributor.authorAiró, Paolo
dc.contributor.authorLunardi, Claudio
dc.contributor.authorRiemekasten, Gabriela
dc.contributor.authorWitte, Torsten
dc.contributor.authorKrieg, Thomas
dc.contributor.authorKreuter, Alexander
dc.contributor.authorDistler, Jörg H W
dc.contributor.authorHunzelmann, Nicolas
dc.contributor.authorKoeleman, Bobby P
dc.contributor.authorVoskuyl, Alexandre E
dc.contributor.authorSchuerwegh, Annemie J
dc.contributor.authorGonzález-Gay, Miguel Angel
dc.contributor.authorRadstake, Timothy R D J
dc.contributor.authorMartin, Javier
dc.contributor.authorBLANCO GARCIA, FRANCISCO JAVIER 
dc.contributor.authorOreiro Villar, Natividad
dc.date.accessioned2017-06-07T06:56:13Z
dc.date.available2017-06-07T06:56:13Z
dc.date.issued2012
dc.identifier.citationTeruel M, Simeon CP, Broen J, Vonk MC, Carreira P, Camps MT, García-Portales R, Delgado-Frías E, Gallego M, Espinosa G; Spanish Scleroderma Group, Beretta L, Airó P, Lunardi C, Riemekasten G, Witte T, Krieg T, Kreuter A, Distler JH, Hunzelmann N, Koeleman BP, Voskuyl AE, Schuerwegh AJ, González-Gay MA, Radstake TR, Martin J. Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis. Arthritis Res Ther. 2012 Jun 25;14(3):R154. doi: 10.1186/ar3890. PMID: 22731751; PMCID: PMC3446540.
dc.identifier.issn1478-6354
dc.identifier.urihttp://hdl.handle.net/20.500.11940/754
dc.description.abstractIntroduction: The aim of the present study was to investigate the possible role of CD40 and CD40 ligand (CD40LG) genes in the susceptibility and phenotype expression of systemic sclerosis (SSc). Methods: In total, 2,670 SSc patients and 3,245 healthy individuals from four European populations (Spain, Germany, The Netherlands, and Italy) were included in the study. Five single-nucleotide polymorphisms (SNPs) of CD40 (rs1883832, rs4810485, rs1535045) and CD40LG (rs3092952, rs3092920) were genotyped by using a predesigned TaqMan allele-discrimination assay technology. Meta-analysis was assessed to determine whether an association exists between the genetic variants and SSc or its main clinical subtypes. Results: No evidence of association between CD40 and CD40LG genes variants and susceptibility to SSc was observed. Similarly, no significant statistical differences were observed when SSc patients were stratified by the clinical subtypes, the serologic features, and pulmonary fibrosis. Conclusions: Our results do not suggest an important role of CD40 and CD40LG gene polymorphisms in the susceptibility to or clinical expression of SSc.
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshCD40 Antigens
dc.subject.meshCD40 Ligand
dc.subject.meshGenetic Predisposition to Disease
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshScleroderma, Systemic
dc.subject.meshGenotype
dc.titleAnalysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis.
dc.typeArtigoes
dc.authorsophosTeruel, Maria
dc.authorsophosTeruel M
dc.authorsophosSimeon, Carmen P
dc.authorsophosSimeon CP
dc.authorsophosBroen, Jasper
dc.authorsophosBroen J
dc.authorsophosVonk, Madelon C
dc.authorsophosVonk MC
dc.authorsophosCarreira, Patricia
dc.authorsophosCarreira P
dc.authorsophosCamps, Maria Teresa
dc.authorsophosCamps MT
dc.authorsophosGarcia-Portales, Rosa
dc.authorsophosGarcia-Portales R
dc.authorsophosDelgado-Frias, Esmeralda
dc.authorsophosDelgado-Frias E
dc.authorsophosGallego, Maria
dc.authorsophosGallego M
dc.authorsophosEspinosa, Gerard
dc.authorsophosEspinosa G
dc.authorsophosBeretta, Lorenzo
dc.authorsophosBeretta L
dc.authorsophosAiro, Paolo
dc.authorsophosAiro P
dc.authorsophosLunardi, Claudio
dc.authorsophosLunardi C
dc.authorsophosRiemekasten, Gabriela
dc.authorsophosRiemekasten G
dc.authorsophosWitte, Torsten
dc.authorsophosWitte T
dc.authorsophosKrieg, Thomas
dc.authorsophosKrieg T
dc.authorsophosKreuter, Alexander
dc.authorsophosKreuter A
dc.authorsophosDistler, Jorg H W
dc.authorsophosDistler JH
dc.authorsophosHunzelmann, Nicolas
dc.authorsophosHunzelmann N
dc.authorsophosKoeleman, Bobby P
dc.authorsophosKoeleman BP
dc.authorsophosVoskuyl, Alexandre E
dc.authorsophosVoskuyl AE
dc.authorsophosSchuerwegh, Annemie J
dc.authorsophosSchuerwegh AJ
dc.authorsophosGonzalez-Gay, Miguel Angel
dc.authorsophosGonzalez-Gay MA
dc.authorsophosRadstake, Timothy R D J
dc.authorsophosRadstake TR
dc.authorsophosMartin, Javier
dc.authorsophosMartin J
dc.identifier.doi10.1186/ar3890
dc.identifier.pmid22731751
dc.identifier.sophos17508
dc.issue.number3
dc.journal.titleARTHRITIS RESEARCH & THERAPY
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña::INIBIC.- Instituto de Investigación Biomédica
dc.rights.accessRightsopenAccess
dc.rights.accessRightsopenAccess
dc.subject.decsAntígenos CD40
dc.subject.decsLigando de CD40
dc.subject.decsPredisposición Genética a la Enfermedad
dc.subject.decsPolimorfismo de Nucleótido Simple
dc.subject.decsEsclerodermia Sistémica
dc.subject.decsGenotipo
dc.typesophosArtículo Original
dc.volume.number14


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Arthritis Res Ther . 2012 Jun 25;14(3):R154

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