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Indoleamine, 2-3 dioxygenase activity could be an early marker of graft rejection in heart transplantation
dc.contributor.author | Barge Caballero, Eduardo | |
dc.contributor.author | Crespo Leiro, Marisa | |
dc.contributor.author | Domenech García, Nieves | |
dc.contributor.author | Castro Beiras, Alfonso | |
dc.contributor.author | Suárez Fuentetaja, Natalia | |
dc.contributor.author | Paniagua Martín, María Jesús | |
dc.contributor.author | Grille Cancela, Zulaika | |
dc.contributor.author | Marzoa Rivas, Raquel | |
dc.contributor.author | Muñiz García, Javier | |
dc.contributor.author | Pombo Otero, Jorge | |
dc.date.accessioned | 2017-06-07T07:32:52Z | |
dc.date.available | 2017-06-07T07:32:52Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 0041-1345 | |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/7790 | |
dc.description.abstract | Background: The indoleamine, 2-3 dioxygenase (IDO) is an inducible intracellular enzyme with immunosuppressive effects mainly on lymphocyte populations. It has been postulated that indirect determination of IDO serum activity may be a marker of renal graft rejection, but its potential usefulness in heart transplantation (HT) is unknown. Methods: This longitudinal study included 98 HT patients (83% males) who survived ≥1 year. Mean age was 54.14 ± 11.57 years. Serum IDO activity was analyzed one month after HT by means of high performance liquid chromatography and correlated with the cumulative incidence of acute rejection (AR) during one-year follow-up. AR was defined as biopsy-proven ≥ ISHLT grade 2R rejection or empirically treated non-biopsy-proven rejection. The study sample was divided into two groups: AR group (n = 51), including patients who experienced at least one AR episode during the first year after HT; No-AR group (N = 47), including the remaining patients. Results: Mean serum IDO activity one month after HT was significantly higher (P = .021) in the AR group (3.32 ± 1.56) than in the no-AR group (2.62 ± 1.35). No significant association between serum IDO activity and gender (male: 3.1 ± 1.56, women: 2.43 ± 0.99, P = .092), recipient age (r = -.07, P = .943) or donor age (r = 0.108, P = 0.293) was observed. By means of binary logistic regression, an odds ratio of 1.4 [CI 95%: 1.033-1.876, P = .03] per unit increase of act-IDO was estimated, with no significant modification upon forced adjustment for age and sex. Mean glomerular filtration rate 1 month after HT was 67.01 ± 28.51 mL/min/m(2). No significant correlation between this parameter and serum IDO activity was observed (r = .160, P = .117). Conclusions: Our study suggests that serum IDO activity one month after HT might be associated with a higher risk of AR during one-year follow-up. This association seems to be independent of recipient gender, age or renal function. | |
dc.language.iso | eng | |
dc.subject.mesh | Graft Rejection | |
dc.subject.mesh | Graft Survival | |
dc.subject.mesh | Supervivencia de Injerto | |
dc.subject.mesh | Heart Transplantation | |
dc.subject.mesh | Indoleamine-Pyrrole 2,3,-Dioxygenase | |
dc.title | Indoleamine, 2-3 dioxygenase activity could be an early marker of graft rejection in heart transplantation | |
dc.type | Artigo | es |
dc.authorsophos | Suarez-Fuentetaja, N. | |
dc.authorsophos | Domenech-Garcia, N. | |
dc.authorsophos | Paniagua-Martin, M. J. | |
dc.authorsophos | Marzoa-Rivas, R. | |
dc.authorsophos | Barge-Caballero, E. | |
dc.authorsophos | Grille-Cancela, Z. | |
dc.authorsophos | Pombo-Otero, J. | |
dc.authorsophos | Muniz-Garcia, J. | |
dc.authorsophos | Castro-Beiras, A. | |
dc.authorsophos | Crespo-Leiro, M. G. | |
dc.identifier.doi | 10.1016/j.transproceed.2012.09.036 | |
dc.identifier.isi | 311531100043 | |
dc.identifier.pmid | 23146482 | |
dc.identifier.sophos | 7784 | |
dc.issue.number | 9 | |
dc.journal.title | TRANSPLANTATION PROCEEDINGS | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario A Coruña::Cardioloxía | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña::INIBIC.- Instituto de Investigación Biomédica | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña::INIBIC.- Instituto de Investigación Biomédica::Instituto Universitario de Ciencias da Saúde | |
dc.rights.accessRights | openAccess | |
dc.subject.decs | Rechazo de Injerto | |
dc.subject.decs | Trasplante de Corazón | |
dc.subject.decs | Indolamina-Pirrol 2,3,-Dioxigenasa | |
dc.typesophos | Artículo Original | |
dc.volume.number | 44 |