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dc.contributor.authorBarge Caballero, Eduardo 
dc.contributor.authorCrespo Leiro, Marisa 
dc.contributor.authorDomenech García, Nieves 
dc.contributor.authorCastro Beiras, Alfonso 
dc.contributor.authorSuárez Fuentetaja, Natalia 
dc.contributor.authorPaniagua Martín, María Jesús 
dc.contributor.authorGrille Cancela, Zulaika
dc.contributor.authorMarzoa Rivas, Raquel 
dc.contributor.authorMuñiz García, Javier 
dc.contributor.authorPombo Otero, Jorge 
dc.date.accessioned2017-06-07T07:32:52Z
dc.date.available2017-06-07T07:32:52Z
dc.date.issued2012
dc.identifier.issn0041-1345
dc.identifier.urihttp://hdl.handle.net/20.500.11940/7790
dc.description.abstractBackground: The indoleamine, 2-3 dioxygenase (IDO) is an inducible intracellular enzyme with immunosuppressive effects mainly on lymphocyte populations. It has been postulated that indirect determination of IDO serum activity may be a marker of renal graft rejection, but its potential usefulness in heart transplantation (HT) is unknown. Methods: This longitudinal study included 98 HT patients (83% males) who survived ≥1 year. Mean age was 54.14 ± 11.57 years. Serum IDO activity was analyzed one month after HT by means of high performance liquid chromatography and correlated with the cumulative incidence of acute rejection (AR) during one-year follow-up. AR was defined as biopsy-proven ≥ ISHLT grade 2R rejection or empirically treated non-biopsy-proven rejection. The study sample was divided into two groups: AR group (n = 51), including patients who experienced at least one AR episode during the first year after HT; No-AR group (N = 47), including the remaining patients. Results: Mean serum IDO activity one month after HT was significantly higher (P = .021) in the AR group (3.32 ± 1.56) than in the no-AR group (2.62 ± 1.35). No significant association between serum IDO activity and gender (male: 3.1 ± 1.56, women: 2.43 ± 0.99, P = .092), recipient age (r = -.07, P = .943) or donor age (r = 0.108, P = 0.293) was observed. By means of binary logistic regression, an odds ratio of 1.4 [CI 95%: 1.033-1.876, P = .03] per unit increase of act-IDO was estimated, with no significant modification upon forced adjustment for age and sex. Mean glomerular filtration rate 1 month after HT was 67.01 ± 28.51 mL/min/m(2). No significant correlation between this parameter and serum IDO activity was observed (r = .160, P = .117). Conclusions: Our study suggests that serum IDO activity one month after HT might be associated with a higher risk of AR during one-year follow-up. This association seems to be independent of recipient gender, age or renal function.
dc.language.isoeng
dc.subject.meshGraft Rejection
dc.subject.meshGraft Survival
dc.subject.meshSupervivencia de Injerto
dc.subject.meshHeart Transplantation
dc.subject.meshIndoleamine-Pyrrole 2,3,-Dioxygenase
dc.titleIndoleamine, 2-3 dioxygenase activity could be an early marker of graft rejection in heart transplantation
dc.typeArtigoes
dc.authorsophosSuarez-Fuentetaja, N.
dc.authorsophosDomenech-Garcia, N.
dc.authorsophosPaniagua-Martin, M. J.
dc.authorsophosMarzoa-Rivas, R.
dc.authorsophosBarge-Caballero, E.
dc.authorsophosGrille-Cancela, Z.
dc.authorsophosPombo-Otero, J.
dc.authorsophosMuniz-Garcia, J.
dc.authorsophosCastro-Beiras, A.
dc.authorsophosCrespo-Leiro, M. G.
dc.identifier.doi10.1016/j.transproceed.2012.09.036
dc.identifier.isi311531100043
dc.identifier.pmid23146482
dc.identifier.sophos7784
dc.issue.number9
dc.journal.titleTRANSPLANTATION PROCEEDINGS
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario A Coruña::Cardioloxía
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña::INIBIC.- Instituto de Investigación Biomédica
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña::INIBIC.- Instituto de Investigación Biomédica::Instituto Universitario de Ciencias da Saúde
dc.rights.accessRightsopenAccess
dc.subject.decsRechazo de Injerto
dc.subject.decsTrasplante de Corazón
dc.subject.decsIndolamina-Pirrol 2,3,-Dioxigenasa
dc.typesophosArtículo Original
dc.volume.number44


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