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Protective Role of the Interleukin 33 rs3939286 Gene Polymorphism in the Development of Subclinical Atherosclerosis in Rheumatoid Arthritis Patients
dc.contributor.author | López-Mejías R | |
dc.contributor.author | Genre F | |
dc.contributor.author | Remuzgo-Martínez S | |
dc.contributor.author | Robustillo-Villarino M | |
dc.contributor.author | García-Bermúdez M | |
dc.contributor.author | Llorca J | |
dc.contributor.author | Corrales A | |
dc.contributor.author | González Juanatey, Carlos | |
dc.contributor.author | Ubilla B | |
dc.contributor.author | Miranda Filloy, José Alberto | |
dc.contributor.author | Mijares V | |
dc.contributor.author | Pina T | |
dc.contributor.author | Blanco R | |
dc.contributor.author | Alegre-Sancho JJ | |
dc.contributor.author | Ramírez Huaranga MA | |
dc.contributor.author | Mínguez Sánchez MD | |
dc.contributor.author | Tejera Segura B | |
dc.contributor.author | Ferraz-Amaro I | |
dc.contributor.author | Vicente E | |
dc.contributor.author | Carmona FD | |
dc.contributor.author | Castañeda S | |
dc.contributor.author | Martín J | |
dc.contributor.author | González-Gay Mantecón, Miguel Ángel | |
dc.date.accessioned | 2017-06-07T07:34:17Z | |
dc.date.available | 2017-06-07T07:34:17Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/8076 | |
dc.description.abstract | OBJECTIVES: To determine whether the interleukin-33 (IL-33)-interleukin-1 receptor like 1 (IL-1RL1) signaling pathway is implicated in the risk of subclinical atherosclerosis in patients with rheumatoid arthritis (RA). METHODS: A total of 576 Spanish RA patients from Northern Spain were genotyped for 6 well-known IL33-IL1RL1 polymorphisms (IL33 rs3939286, IL33 rs7025417, IL33 rs7044343, IL1RL1 rs2058660, IL1RL1 rs2310173 and IL1RL1 rs13015714) by TaqMan genotyping assay. The presence of subclinical atherosclerosis was determined by the assessment of carotid intima-media thickness (cIMT) by carotid ultrasound (US). RESULTS: RA patients carrying the TT genotype of the IL33 rs3939286 polymorphism had lower cIMT values than those homozygous for the CC genotype (mean +/- standard deviation (SD): 0.71 +/- 0.14 mm versus 0.76 +/- 0.16 mm, respectively) while patients carrying the CT genotype had intermediate cIMT values (mean +/- SD: 0.73 +/- 0.17 mm). Moreover, RA patients carrying the mutant allele T of the IL33 rs3939286 polymorphism exhibited significantly lower cIMT values than those carrying the wild allele C (mean +/- SD: 0.72 +/- 0.16 mm versus 0.75 +/- 0.18 mm respectively; p = 0.04). The association of both genotype and allele frequencies of IL33 rs3939286 and cIMT levels remained statistically significant after adjustment for sex, age at the time of US study, follow-up and center (p = 0.006 and p = 0.0023, respectively), evidencing that the potential effect conferred by IL33 rs3939286 may be independent of confounder factors. No association with other IL33-IL1RL1 genetic variants was observed. CONCLUSIONS: In conclusion, our results may suggest a potential protective effect of the IL33 rs3939286 allele T in the risk of subclinical atherosclerosis in patients with RA. | |
dc.description.sponsorship | European Union FEDER | |
dc.description.sponsorship | Instituto de Salud Carlos III (ISCIII)/Fondo de Investigación Sanitaria | |
dc.description.sponsorship | European Commission | |
dc.description.sponsorship | RECTIS Programs del Instituto de Salud Carlos III (ISCIII) | |
dc.description.sponsorship | European IMI BTCure Program | |
dc.description.sponsorship | RECTIS Program (RIER) | |
dc.language.iso | eng | |
dc.rights | Atribución 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Aged | |
dc.subject.mesh | Alleles | |
dc.subject.mesh | Arthritis, Rheumatoid | |
dc.subject.mesh | Atherosclerosis | |
dc.subject.mesh | Carotid Arteries | |
dc.subject.mesh | Female | |
dc.subject.mesh | Follow-Up Studies | |
dc.subject.mesh | Gene Frequency | |
dc.subject.mesh | Genotype | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Interleukin-33 | |
dc.subject.mesh | Linkage Disequilibrium | |
dc.subject.mesh | Male | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Polymorphism, Single Nucleotide | |
dc.subject.mesh | Receptors, Interleukin-1 Type I | |
dc.subject.mesh | Risk | |
dc.subject.mesh | Ultrasonography | |
dc.title | Protective Role of the Interleukin 33 rs3939286 Gene Polymorphism in the Development of Subclinical Atherosclerosis in Rheumatoid Arthritis Patients | |
dc.type | Artigo | es |
dc.authorsophos | López-Mejías R | |
dc.authorsophos | Genre F | |
dc.authorsophos | Remuzgo-Martínez S | |
dc.authorsophos | Robustillo-Villarino M | |
dc.authorsophos | García-Bermúdez M | |
dc.authorsophos | Llorca J | |
dc.authorsophos | Corrales A | |
dc.authorsophos | González-Juanatey C | |
dc.authorsophos | Ubilla B | |
dc.authorsophos | Miranda-Filloy JA | |
dc.authorsophos | Mijares V | |
dc.authorsophos | Pina T | |
dc.authorsophos | Blanco R | |
dc.authorsophos | Alegre-Sancho JJ | |
dc.authorsophos | Ramírez Huaranga MA | |
dc.authorsophos | Mínguez Sánchez MD | |
dc.authorsophos | Tejera Segura B | |
dc.authorsophos | Ferraz-Amaro I | |
dc.authorsophos | Vicente E | |
dc.authorsophos | Carmona FD | |
dc.authorsophos | Castañeda S | |
dc.authorsophos | Martín J | |
dc.authorsophos | González-Gay MA | |
dc.identifier.doi | 10.1371/journal.pone.0143153 | |
dc.identifier.pmid | 26571131 | |
dc.identifier.sophos | 19425 | |
dc.issue.number | 11 | |
dc.journal.title | PLoS One | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago - Complexo Hospitalario Universitario de Santiago::Reumatoloxía | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Lugo - Hospital Universitario Lucus Augusti::Cardioloxía | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Lugo - Hospital Universitario Lucus Augusti::Reumatoloxía | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago | |
dc.relation.projectID | ISCIII/PI06/0024 | |
dc.relation.projectID | ISCIII/PS09/00748 | |
dc.relation.projectID | ISCIII/PI12/00060 | |
dc.relation.projectID | RETICS/RD12/0009 (RIER) | |
dc.relation.projectID | ISCIII/CD12/00425 | |
dc.relation.projectID | RIER/RD12/0009/0013 | |
dc.rights.accessRights | openAccess | |
dc.typesophos | Artículo Original | |
dc.volume.number | 10 |