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The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases

dc.contributor.authorAbella Cajigal, Vanesa
dc.contributor.authorScotece, Morena
dc.contributor.authorConde Aranda, Javier
dc.contributor.authorGómez Bahamonde, Rodolfo
dc.contributor.authorLois, A.
dc.contributor.authorPino Mínguez, Jesús 
dc.contributor.authorGómez-Reino Carnota, Juan Jesús 
dc.contributor.authorLago Paz, Francisca 
dc.contributor.authorMobasheri, A.
dc.contributor.authorGualillo ., Oreste 
dc.date.accessioned2017-06-07T07:34:30Z
dc.date.available2017-06-07T07:34:30Z
dc.date.issued2015
dc.identifier.issn1354-750X
dc.identifier.urihttp://hdl.handle.net/20.500.11940/8120
dc.description.abstractLipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a secreted glycoprotein that belongs to a group of transporters of small lipophilic molecules in circulation. LCN2 has been recently characterized as an adipose-derived cytokine. This adipokine is believed to bind small substances, such as steroids and lipopolysaccharides, and has been reported to have roles in the induction of apoptosis in hematopoietic cells, transport of fatty acids and iron, modulation of inflammation, and metabolic homeostasis. Recently, LCN2 has emerged as a useful biomarker and rheumatic diseases. This review provides an overview of LCN2 in inflammation, immunity, and metabolism.
dc.description.sponsorshipInstituto de Salud Carlos III (ISCIII)
dc.description.sponsorshipSerivizo Galego de Saúde (SERGAS)
dc.description.sponsorshipComisión Europeaes
dc.description.sponsorshipVersus Arthritis
dc.description.sponsorshipDeanship of Scientific Research (DSR), King AbdulAziz University
dc.description.sponsorshipXunta de Galicia/ESF (European Social Fund)
dc.description.sponsorshipUniversidad de Coruña
dc.description.sponsorshipGobierno de España
dc.description.sponsorshipFundación IDIS-Ramón Domínguez
dc.description.sponsorshipRECTIS Programme/RIER/RD12/0009/0008
dc.description.sponsorshipISCIII/PI14/00016
dc.description.sponsorshipISCIII/PIE13/00024
dc.description.sponsorshipEU FP7/HEALTH.2012.2.4.5-2 305815
dc.description.sponsorshipVersus Arthritis/20194
dc.description.sponsorshipDeanship of Scientific Research (DSR), King AbdulAziz University/1-141/1434 HiCi
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivatives License
dc.rights.urihttp://creativecommons.org/Licenses/by-nc-nd/4.0/
dc.subject.meshAcute-Phase Proteins
dc.subject.meshAnimals
dc.subject.meshBiomarkers
dc.subject.meshHumans
dc.subject.meshInflammation
dc.subject.meshInflammation Mediators
dc.subject.meshLipocalin-2
dc.subject.meshLipocalins
dc.subject.meshMetabolic Diseases
dc.subject.meshPredictive Value of Tests
dc.subject.meshPrognosis
dc.subject.meshProto-Oncogene Proteins
dc.subject.meshAdipokines
dc.titleThe potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases
dc.typeArtigoes
dc.authorsophosAbella, V.
dc.authorsophosScotece, M.
dc.authorsophosConde, J.
dc.authorsophosGómez, R.
dc.authorsophosLois, A.
dc.authorsophosPino, J.
dc.authorsophosGómez-Reino, J. J.
dc.authorsophosLago, F.
dc.authorsophosMobasheri, A.
dc.authorsophosGualillo, O.
dc.identifier.doi10.3109/1354750X.2015.1123354
dc.identifier.isi372092300008
dc.identifier.pmid26671823
dc.identifier.sophos19466
dc.issue.number8
dc.journal.titleBIOMARKERS
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago - Complexo Hospitalario Universitario de Santiago::Reumatoloxía
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago - Complexo Hospitalario Universitario de Santiago::Traumatoloxía
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago
dc.page.initial565
dc.page.final571
dc.rights.accessRightsopenAccess
dc.typesophosArtículo Original
dc.volume.number20


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Biomarkers . 2015;20(8):565-71. doi: 10.3109/1354750X.2015.1123354. Epub 2015 Dec 15.

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