Mostrar el registro sencillo del ítem

dc.contributor.authorGUERRERO CASTRO, ANA MARIA 
dc.contributor.authorIglesias García, Cristina
dc.contributor.authorRaguz, Selina
dc.contributor.authorFloridia, Ebel
dc.contributor.authorGil, Jesús
dc.contributor.authorPombo Ramos, Celia María
dc.contributor.authorZalvide Torrente, Juan
dc.date.accessioned2017-06-07T07:36:00Z
dc.date.available2017-06-07T07:36:00Z
dc.date.issued2015
dc.identifier.issn1474-9718
dc.identifier.urihttp://hdl.handle.net/20.500.11940/8377
dc.description.abstractMutations in cerebral cavernous malformation 3 gene are known to result in development of vascular malformations and have recently been proposed to also give rise to meningiomas. We report in this study that lack of CCM3 unexpectedly impairs the senescence response of cells, and this is related to the inability of CCM3-deficient cells to induce the C/EBPβ transcription factor and implement the senescence-associated secretory phenotype. Induction of C/EBPβ and cytokines is also impaired in the absence of CCM3 in response to cytokines in nonsenescent cells, pointing to it being a primary defect and not secondary to impaired senescence. CCM3-deficient cells also have a defect in autophagy at late passages of culture, and this defect is also not dependent on impaired senescence, as it is evident in immortal cells after nutrient starvation. Further, these two defects may be related, as enforcing autophagy in CCM3-deficient late passage cells increases C/EBPβ cytokine expression. These results broaden our knowledge on the mechanisms by which CCM3 deficiency results in disease and open new avenues of research into both CCM3 and senescence biology.en
dc.description.sponsorshipXunta de Galiciaes
dc.description.sponsorshipMinisterio de Ciencia e Innovaciónes
dc.language.isoeng
dc.rightsAttribution
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshApoptosis Regulatory Proteinsen
dc.subject.meshCellular Senescenceen
dc.subject.meshCellular Senescenceen
dc.subject.meshMembrane Proteinsen
dc.subject.meshMutationen
dc.subject.meshProto-Oncogene Proteinsen
dc.titleThe cerebral cavernous malformation 3 gene is necessary for senescence induction
dc.typeArtigoes
dc.authorsophosGuerrero, A.
dc.authorsophosIglesias, C.
dc.authorsophosRaguz, S.
dc.authorsophosFloridia, E.
dc.authorsophosGil, J.
dc.authorsophosPombo, C. M.
dc.authorsophosZalvide, J.
dc.identifier.doi10.1111/acel.12316
dc.identifier.isi350659900013
dc.identifier.pmid25655101
dc.identifier.sophos18645
dc.issue.number2
dc.journal.titleAGING CELL
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago
dc.page.initial274
dc.page.final83
dc.relation.projectIDXunta de Galicia/INCITE 09 208 110
dc.relation.projectIDXunta de Galicia/GCP2013-032es
dc.relation.projectIDMinisterio de Ciencia e Innovación/SAF2011-24940es
dc.relation.projectIDRegional Development European Funds
dc.relation.projectIDERANET/neuronPRI_PIMNEU-2011-1337
dc.rights.accessRightsopenAccess
dc.subject.decsMutaciónes
dc.subject.decsProteínas Proto-Oncogénicases
dc.subject.decsProteínas Reguladoras de la Apoptosises
dc.subject.decsProteínas de la Membranaes
dc.subject.decsSenescencia Celulares
dc.typesophosArtículo Original
dc.volume.number14


Ficheros en el ítem

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Attribution
Excepto si se señala otra cosa, la licencia del ítem se describe como Attribution