Predicting Outcome and Therapy Response in mCRC Patients Using an Indirect Method for CTCs Detection by a Multigene Expression Panel: A Multicentric Prospective Validation Study
Vidal Insua, Yolanda; De La Cámara Gómez, Juan Cruz; Brozos Vázquez, Elena María; Fernández Montes, Ana; Vázquez Rivera, Francisca; Villanueva Silva, María José; Barbazán García, Jorge; Muinelo Romay , Laura; Candamio Folgar, Sonia; Abalo Piñeiro, Alicia; López López, Rafael; Abal Posada, Miguel; Alonso Alconada, Lorena
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Identificadores
URI: http://hdl.handle.net/20.500.11940/9421
PMID: 28608814
DOI: 10.3390/ijms18061265
ESSN: 1422-0067
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Fecha de publicación
2017-06-13Título de revista
International journal of molecular sciences
Tipo de contenido
Artigo
DeCS
supervivencia sin enfermedad | tasa de supervivencia | metástasis neoplásica | detección precoz del cáncer | neoplasias colorrectales | células neoplásicas circulantesMeSH
Early Detection of Cancer | Neoplastic Cells, Circulating | Disease-Free Survival | Neoplasm Metastasis | Survival Rate | Colorectal NeoplasmsCIE
Tumor maligno del colon, parte no especificadaResumen
Colorectal cancer (CRC) is one of the major causes of cancer-related deaths. Early detection of tumor relapse is crucial for determining the most appropriate therapeutic management. In clinical practice, computed tomography (CT) is routinely used, but small tumor changes are difficult to visualize, and reliable blood-based prognostic and monitoring biomarkers are urgently needed. The aim of this study was to prospectively validate a gene expression panel (composed of GAPDH, VIL1, CLU, TIMP1, TLN1, LOXL3 and ZEB2) for detecting circulating tumor cells (CTCs) as prognostic and predictive tool in blood samples from 94 metastatic CRC (mCRC) patients. Patients with higher gene panel expression before treatment had a reduced progression-free survival (PFS) and overall-survival (OS) rates compared with patients with low expression (p = 0.003 and p ≤ 0.001, respectively). Patients with increased expression of CTCs markers during treatment presented PFS and OS times of 8.95 and 11.74 months, respectively, compared with 14.41 and 24.7 for patients presenting decreased expression (PFS; p = 0.020; OS; p ≤ 0.001). Patients classified as non-responders by CTCs with treatment, but classified as responders by CT scan, showed significantly shorter survival times (PFS: 8.53 vs. 11.70; OS: 10.37 vs. 24.13; months). In conclusion, our CTCs detection panel demonstrated efficacy for early treatment response assessment in mCRC patients, and with increased reliability compared to CT scan.
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