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dc.contributor.authorPURRIÑOS HERMIDA, MARIA JESUS 
dc.contributor.authorSantiago Pérez, María Isolina
dc.contributor.authorTreviño Castellano, Mercedes 
dc.contributor.authorDOPAZO RODRIGUEZ, RAFAELA 
dc.contributor.authorCañizares Castellanos, Angelina 
dc.contributor.authorBONACHO PANIAGUA, ISOLINA 
dc.contributor.authorTrigo Daporta, Matilde 
dc.contributor.authorFernández, M. Eva
dc.contributor.authorCid Lama, Ana 
dc.contributor.authorGómez Sánchez, David 
dc.contributor.authorOrdoñez Barrosa, Patricia 
dc.contributor.authorCoira Nieto, Amparo
dc.contributor.authorArmada Fernández, Maria Jose 
dc.contributor.authorPorto Quintans, Maria Magdalena 
dc.contributor.authorPérez Castro, Sonia 
dc.contributor.authorMalvar Pintos, Alberto
dc.date.accessioned2018-09-21T11:02:39Z
dc.date.available2018-09-21T11:02:39Z
dc.date.issued2018
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/30075010es
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075752/es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/10961
dc.description.abstractBivalent human papillomavirus (HPV) vaccine was incorporated into the childhood vaccination calendar in Galicia, Spain in 2008. The objectives of this study were to estimate direct, indirect and total effectiveness of HPV vaccine and to identify sexual habits changes in the post-vaccination period in Galicia, Spain.Endocervical scrapings of 745 women attending 7 Health Areas of the Galician Public Health Service were collected in the post-vaccination period, from 2014-2017. Two groups were studied: women born between 1989 and 1993 (n = 397) and women born in 1994 or later (n = 348). Twelve high-risk human papillomavirus (HR-HPV) genotypes were detected by Cobas® 4800 HPV test (Roche Diagnostics, Mannheim, Germany). The Linear Array® HPV Genotyping Test (Roche Diagnostics) was used for HR-HPV genotype detection other than HPV 16/18. Information about sexual habits was collected by a self-filled questionnaire. Post-vaccination data were compared to previously published pre-vaccination data obtained between 2008 and 2010 in Galicia from women of the same age (18-26 years old, n = 523). The Stata 14.2 software was employed for statistical analyses.Data from 392 unvaccinated and 353 vaccinated women were compared. For unvaccinated and vaccinated women, HPV 16/18 prevalence was 9.2% and 0.8%, respectively, and HPV 31/33/45 prevalence was 8.4% and 1.1%, respectively. Direct, indirect and total effectiveness of the HPV vaccine were (%, 95% CI): 94 (72-99), 30 (-11-56) and 95 (79-99), respectively, for HPV 16/18 and 83 (46-94), -10 (-88-33) and 84 (54-94), respectively, for HPV 31/33/45. The number of women with first intercourse before 17 years old and 3 or more sexual partners along life was higher in the post-vaccination period (p < 0.05). A positive impact of bivalent HPV vaccine was observed, both on direct and cross protection. Sexual habits could have changed in the post-vaccination period.es
dc.description.sponsorshipFunded by CIF: S 15 11 00 1 H. Dirección xeral de Saúde Pública. Consellería de Sanidade. Santiago de Compostelaes
dc.language.isoenges
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshVaccination *
dc.subject.meshHuman papillomavirus 31 *
dc.subject.meshHuman papillomavirus 18 *
dc.subject.meshHuman papillomavirus 16 *
dc.subject.meshHealth Surveys *
dc.subject.meshPapillomavirus Vaccines *
dc.subject.meshCross Protection *
dc.subject.meshGenotype *
dc.subject.meshSexual Behavior *
dc.subject.meshPrevalence *
dc.titleDirect, indirect and total effectiveness of bivalent HPV vaccine in women in Galicia, Spaines
dc.typeArtigoes
dc.identifier.doi10.1371/journal.pone.0201653
dc.identifier.essn1932-6203
dc.identifier.pmid30075010
dc.issue.number8es
dc.journal.titlePLOS ONEes
dc.organizationConsellería de Sanidade::Dirección Xeral de Saúde Pública::Subdirección Xeral de Información sobre Saúde e Epidemioloxía::Servizo de Epidemioloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Microbioloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Xinecoloxía y Obstetriciaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña ::Microbioloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña ::Xinecoloxía y Obstetriciaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Pontevedra e O Salnés - Complexo Hospitalario Universitario de Pontevedra::Microbioloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Pontevedra e O Salnés - Complexo Hospitalario Universitario de Pontevedra::Xinecoloxía y Obstetriciaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Ourense, Verín e O Barco de Valdeorras - Complexo Hospitalario Universitario de Ourense::Microbioloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Ourense, Verín e O Barco de Valdeorras - Complexo Hospitalario Universitario de Ourense::Xinecoloxía y Obstetriciaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Ferrol – Complexo Hospitalario Universitario de Ferrol::Microbioloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Lugo, Cervo e Monforte de lemos - Complexo Hospitalario Universitario Lucus Augusti::Microbioloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Lugo, Cervo e Monforte de lemos -Atención Primaria::Centro Saude Fingoi (LUGO)es
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Vigo - Complexo Hospitalario Universitario de Vigo::Xinecoloxía y Obstetriciaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Vigo - Complexo Hospitalario Universitario de Vigo::Microbioloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Fundación Biomédica Galicia Sures
dc.page.initiale0201653es
dc.relation.publisherversionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201653es
dc.rights.accessRightsopenAccesses
dc.subject.cie10Papilomavirus como causa de enfermedades clasificadas en otros capítulos es
dc.subject.decspapilomavirus humano 31 *
dc.subject.decsencuestas de salud *
dc.subject.decsprotección cruzada *
dc.subject.decsprevalencia *
dc.subject.decsgenotipo *
dc.subject.decsvacunación *
dc.subject.decsvirus del papiloma humano 16 *
dc.subject.decsvirus del papiloma humano 18 *
dc.subject.decsvacunas para papilomavirus *
dc.subject.decsconducta sexual *
dc.subject.keywordVacina do papillomaviruses
dc.subject.keywordVacuna del papillomaviruses
dc.typefidesArtigo Científico (inclue Orixinal, Orixinal breve, Revisión Sistemática e Meta-análisis)es
dc.typesophosArtículo Originales
dc.volume.number13es


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Atribución 4.0 Internacional
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