Glucagon Control on Food Intake and Energy Balance
Identificadores
Identificadores
URI: http://hdl.handle.net/20.500.11940/15365
PMID: 31405212
DOI: 10.3390/ijms20163905
ISSN: 1661-6596
Visualización o descarga de ficheros
Visualización o descarga de ficheros
Fecha de publicación
2019Título de revista
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Tipo de contenido
Artigo
DeCS
animales | glucosa | regulación del apetito | peso corporal | fármacos antiobesidad | glucagón | metabolismo lipídico | metabolismo energético | obesidad | péptidos | humanos | termogénesis | terapia molecular selectiva | diabetes mellitus | hipoglicemiantesMeSH
Hypoglycemic Agents | Peptides | Obesity | Lipid Metabolism | Animals | Glucagon | Glucose | Anti-Obesity Agents | Body Weight | Humans | Appetite Regulation | Diabetes Mellitus | Thermogenesis | Energy Metabolism | Molecular Targeted TherapyResumen
Glucagon exerts pleiotropic actions on energy balance and has emerged as an attractive target for the treatment of diabetes and obesity in the last few years. Glucagon reduces body weight and adiposity by suppression of appetite and by modulation of lipid metabolism. Moreover, this hormone promotes weight loss by activation of energy expenditure and thermogenesis. In this review, we cover these metabolic actions elicited by glucagon beyond its canonical regulation of glucose metabolism. In addition, we discuss recent developments of therapeutic approaches in the treatment of obesity and diabetes by dual- and tri-agonist molecules based on combinations of glucagon with other peptides. New strategies using these unimolecular polyagonists targeting the glucagon receptor (GCGR), have become successful approaches to evaluate the multifaceted nature of glucagon signaling in energy balance and metabolic syndrome.