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dc.contributor.authorAl-Massadi, O.
dc.contributor.authorFernø, J.
dc.contributor.authorDiéguez González, Carlos
dc.contributor.authorNogueiras Pozo, Rubén
dc.contributor.authorQuiñones, M.
dc.date.accessioned2021-09-29T12:42:35Z
dc.date.available2021-09-29T12:42:35Z
dc.date.issued2019
dc.identifier.issn1661-6596
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/31405212es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/15365
dc.description.abstractGlucagon exerts pleiotropic actions on energy balance and has emerged as an attractive target for the treatment of diabetes and obesity in the last few years. Glucagon reduces body weight and adiposity by suppression of appetite and by modulation of lipid metabolism. Moreover, this hormone promotes weight loss by activation of energy expenditure and thermogenesis. In this review, we cover these metabolic actions elicited by glucagon beyond its canonical regulation of glucose metabolism. In addition, we discuss recent developments of therapeutic approaches in the treatment of obesity and diabetes by dual- and tri-agonist molecules based on combinations of glucagon with other peptides. New strategies using these unimolecular polyagonists targeting the glucagon receptor (GCGR), have become successful approaches to evaluate the multifaceted nature of glucagon signaling in energy balance and metabolic syndrome.en
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshHypoglycemic Agents*
dc.subject.meshPeptides*
dc.subject.meshObesity*
dc.subject.meshLipid Metabolism*
dc.subject.meshAnimals*
dc.subject.meshGlucagon*
dc.subject.meshGlucose*
dc.subject.meshAnti-Obesity Agents*
dc.subject.meshBody Weight*
dc.subject.meshHumans*
dc.subject.meshAppetite Regulation*
dc.subject.meshDiabetes Mellitus*
dc.subject.meshThermogenesis*
dc.subject.meshEnergy Metabolism*
dc.subject.meshMolecular Targeted Therapy*
dc.titleGlucagon Control on Food Intake and Energy Balancees
dc.typeArtigoes
dc.authorsophosAl-Massadi, O.
dc.authorsophosFernø, J.
dc.authorsophosDiéguez, C.
dc.authorsophosNogueiras, R.
dc.authorsophosQuiñones, M.
dc.identifier.doi10.3390/ijms20163905
dc.identifier.pmid31405212
dc.identifier.sophos30527
dc.issue.number16es
dc.journal.titleINTERNATIONAL JOURNAL OF MOLECULAR SCIENCESes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
dc.page.initial3905es
dc.relation.publisherversionhttps://res.mdpi.com/d_attachment/ijms/ijms-20-03905/article_deploy/ijms-20-03905.pdf
dc.rights.accessRightsopenAccess
dc.subject.decsanimales*
dc.subject.decsglucosa*
dc.subject.decsregulación del apetito*
dc.subject.decspeso corporal*
dc.subject.decsfármacos antiobesidad*
dc.subject.decsglucagón*
dc.subject.decsmetabolismo lipídico*
dc.subject.decsmetabolismo energético*
dc.subject.decsobesidad*
dc.subject.decspéptidos*
dc.subject.decshumanos*
dc.subject.decstermogénesis*
dc.subject.decsterapia molecular selectiva*
dc.subject.decsdiabetes mellitus*
dc.subject.decshipoglicemiantes*
dc.subject.keywordIDIS
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)
dc.typesophosArtículo de Revisión
dc.volume.number20es


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Atribución 4.0 Internacional
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