Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer
Ferreira, M. A.; Gamazon, E. R.; Al-Ejeh, F.; Aittomäki, K.; Andrulis, I. L.; Anton-Culver, H.; Arason, A.; Arndt, V.; Aronson, K. J.; Arun, B. K.; Asseryanis, E.; Azzollini, J.; Balmaña, J.; Barnes, D. R.; Barrowdale, D.; Beckmann, M. W.; Behrens, S.; Benitez, J.; Bermisheva, M.; Białkowska, K.; Blomqvist, C.; Bogdanova, N. V.; Bojesen, S. E.; Bolla, M. K.; Borg, A.; Brauch, H.; Brenner, H.; Broeks, A.; Burwinkel, B.; Caldés, T.; Caligo, M. A.; Campa, D.; Campbell, I.; Canzian, F.; Carter, J.; Carter, B. D.; Castelao Fernández, José Esteban; Chang-Claude, J.; Chanock, S. J.; Christiansen, H.; Chung, W. K.; Claes, K. B. M.; Clarke, C. L.; Couch, F. J.; Cox, A.; Cross, S. S.; Czene, K.; Daly, M. B.; de la Hoya, M.; Dennis, J.; Devilee, P.; Diez, O.; Dörk, T.; Dunning, A. M.; Dwek, M.; Eccles, D. M.; Ejlertsen, B.; Ellberg, C.; Engel, C.; Eriksson, M.; Fasching, P. A.; Fletcher, O.; Flyger, H.; Friedman, E.; Frost, D.; Gabrielson, M.; Gago Dominguez, Manuela; Ganz, P. A.; Gapstur, S. M.; Garber, J.; García-Closas, M.; García-Sáenz, J. A.; Gaudet, M. M.; Giles, G. G.; Glendon, G.; Godwin, A. K.; Goldberg, M. S.; Goldgar, D. E.; González-Neira, A.; Greene, M. H.; Gronwald, J.; Guénel, P.; Haiman, C. A.; Hall, P.; Hamann, U.; He, W.; Heyworth, J.; Hogervorst, F. B. L.; Hollestelle, A.; Hoover, R. N.; Hopper, J. L.; Hulick, P. J.; Humphreys, K.; Imyanitov, E. N.; Isaacs, C.; Jakimovska, M.; Jakubowska, A.; James, P. A.; Janavicius, R.; Jankowitz, R. C.; John, E. M.; Johnson, N.; Joseph, V.; Karlan, B. Y.; Khusnutdinova, E.; Kiiski, J. I.; Ko, Y. D.; Jones, M. E.; Konstantopoulou, I.; Kristensen, V. N.; Laitman, Y.; Lambrechts, D.; Lazaro, C.; Leslie, G.; Lester, J.; Lesueur, F.; Lindström, S.; Long, J.; Loud, J. T.; Lubiński, J.; Makalic, E.; Mannermaa, A.; Manoochehri, M.; Margolin, S.; Maurer, T.; Mavroudis, D.; McGuffog, L.; Meindl, A.; Menon, U.; Michailidou, K.; Miller, A.; Montagna, M.; Moreno, F.; Moserle, L.; Mulligan, A. M.; Nathanson, K. L.; Neuhausen, S. L.; Nevanlinna, H.; Nevelsteen, I.; Nielsen, F. C.; Nikitina-Zake, L.; Nussbaum, R. L.; Offit, K.; Olah, E.; Olopade, O. I.; Olsson, H.; Osorio, A.; Papp, J.; Park-Simon, T. W.; Parsons, M. T.; Pedersen, I. S.; Peixoto, A.; Peterlongo, P.; Pharoah, P. D. P.; Plaseska-Karanfilska, D.; Poppe, B.; Presneau, N.; Radice, P.; Rantala, J.; Rennert, G.; Risch, H. A.; Saloustros, E.; Sanden, K.; Sawyer, E. J.; Schmidt, M. K.; Schmutzler, R. K.; Sharma, P.; Shu, X. O.; Simard, J.; Singer, C. F.; Soucy, P.; Southey, M. C.; Spinelli, J. J.; Spurdle, A. B.; Stone, J.; Swerdlow, A. J.; Tapper, W. J.; Taylor, J. A.; Teixeira, M. R.; Terry, M. B.; Teulé, A.; Thomassen, M.; Thöne, K.; Thull, D. L.; Tischkowitz, M.; Toland, A. E.; Torres, D.; Truong, T.; Tung, N.; Vachon, C. M.; van Asperen, C. J.; van den Ouweland, A. M. W.; van Rensburg, E. J.; Vega Gliemmo, Ana; Viel, A.; Wang, Q.; Wappenschmidt, B.; Weitzel, J. N.; Wendt, C.; Winqvist, R.; Yang, X. R.; Yannoukakos, D.; Ziogas, A.; Kraft, P.; Antoniou, A. C.; Zheng, W.; Easton, D. F.; Milne, R. L.; Beesley, J.; Chenevix-Trench, G.; Collaborators, EMBRACE; Collaborators, GC-HBOC Study; Collaborators, GEMO Study; Investigators, ABCTB; Investigators, HEBON; Investigators, BCFR
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Identificadores
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Autor corporativo
EMBRACE Collaborators; GC-HBOC Study Collaborators; GEMO Study Collaborators; ABCTB Investigators; HEBON Investigators; BCFR InvestigatorsFecha de publicación
2019Título de revista
Nature Communications
Tipo de contenido
Artigo
DeCS
humanos | estudio de asociación genómica completa | perfiles de expresión génica | sitios de rasgos cuantitativosMeSH
Humans | Quantitative Trait Loci | Genome-Wide Association Study | Gene Expression ProfilingResumen
Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several with a known immune function. We determine the directional effect of gene expression on disease risk measured based on single and multiple eQTL. In addition, using a gene-based test of association that considers eQTL from multiple tissues, we identify seven (and four) regions with variants associated with overall (and ER-negative) breast cancer risk, which were not reported in previous GWAS. Further investigation of the function of the implicated genes in breast and immune cells may provide insights into the etiology of breast cancer.