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Staging and managing patients with acromegaly in clinical practice: baseline data from the SAGIT (R) validation study
dc.contributor.author | Giustina, A. | |
dc.contributor.author | Bronstein, M. D. | |
dc.contributor.author | Chanson, P. | |
dc.contributor.author | Petersenn, S. | |
dc.contributor.author | Casanueva Freijo, Felipe | |
dc.contributor.author | Sert, C. | |
dc.contributor.author | Houchard, A. | |
dc.contributor.author | Melmed, S. | |
dc.date.accessioned | 2021-11-04T10:49:00Z | |
dc.date.available | 2021-11-04T10:49:00Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1386-341X | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/31338660 | es |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728296/pdf/11102_2019_Article_977.pdf | es |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/31338660 | es |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728296/pdf/11102_2019_Article_977.pdf | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/15642 | |
dc.description.abstract | PURPOSE: The SAGIT(R) instrument, designed to assist clinicians to stage acromegaly, assess treatment response and adapt patient management, was well received by endocrinologists in a pilot study. We report an interim analysis of baseline data from the validation phase. METHODS: The SAGIT(R) validation study (ClinicalTrials.gov NCT02539927) is an international, non-interventional study. Data collection included: demographic/disease characteristics; medical/surgical histories; concomitant acromegaly treatments; investigators' subjective evaluation of disease-control status (clinical global evaluation of disease control [CGE-DC]; controlled/not controlled/yet to be clarified) and clinical disease activity (active/not active); growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels; investigators' therapeutic decision. RESULTS: Of 228 patients enrolled, investigators considered disease to be controlled in 110 (48.2%), not controlled in 105 (46.1%), and yet to be clarified in 13 (5.7%) according to CGE-DC. Thirty-three patients were treatment-naive (not controlled, n = 31; yet to be clarified, n = 2). Investigators considered 48.2% patients in the controlled and 95.2% in the not-controlled groups to have clinically active disease. In the controlled group, 29.7% of patients did not exhibit hormonal control (GH </= 2.5 microg/L; normalized IGF-1) and 47.3% did not have rigorous hormonal control (GH < 1.0 microg/L; normalized IGF-1) by contemporary consensus. Current acromegaly treatment was continued with no change for 91.8% of patients in the controlled and 40.0% in the not-controlled groups. CONCLUSIONS: These data highlight discrepancies between investigator-evaluated disease-control status, disease activity, hormonal control, and treatment decisions in acromegaly. Once validated, the SAGIT(R) instrument may assist clinicians in making active management decisions for patients with acromegaly. | en |
dc.language.iso | eng | es |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Adult | * |
dc.subject.mesh | Middle Aged | * |
dc.subject.mesh | Insulin-Like Growth Factor I | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Pilot Projects | * |
dc.subject.mesh | Human Growth Hormone | * |
dc.subject.mesh | Aged | * |
dc.subject.mesh | Acromegaly | * |
dc.title | Staging and managing patients with acromegaly in clinical practice: baseline data from the SAGIT (R) validation study | es |
dc.type | Artigo | es |
dc.identifier.doi | 10.1007/s11102-019-00977-5 | |
dc.identifier.pmid | 31338660 | |
dc.identifier.sophos | 31239 | |
dc.issue.number | 5 | es |
dc.journal.title | Pituitary | es |
dc.organization | Servizo Galego de Saúde | es |
dc.page.initial | 476 | es |
dc.page.final | 487 | es |
dc.rights.accessRights | openAccess | es |
dc.subject.decs | factor I de crecimiento insulinoide | * |
dc.subject.decs | anciano | * |
dc.subject.decs | proyectos piloto | * |
dc.subject.decs | mediana edad | * |
dc.subject.decs | humanos | * |
dc.subject.decs | acromegalia | * |
dc.subject.decs | adulto | * |
dc.subject.decs | hormona del crecimiento humana | * |
dc.subject.keyword | CHUS | es |
dc.typefides | Artículo Original | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 22 | es |