Deciphering predictive factors for choice of thrombopoietin receptor agonist, treatment free responses, and thrombotic events in immune thrombocytopenia
Lozano, Maria L; Mingot-Castellano, Maria E; Perera, Maria M; Jarque, Isidro; Campos-Alvarez, Rosa M; Gonzalez-Lopez, Tomas J; Carreno-Tarragona, Gonzalo; Bermejo, Nuria; López Fernández, María Fernanda; de Andres, Aurora; Valcarcel, David; Casado-Montero, Luis F; Alvarez-Roman, Maria T; Orts, Maria I; Novelli, Silvana; Revilla, Nuria; Gonzalez-Porras, Jose R; Bolanos, Estefania; Rodríguez López, Manuel; Orna-Montero, Elisa; Vicente, Vicente
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Identificadores
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Fecha de publicación
2019Título de revista
Scientific Reports
Tipo de contenido
Artigo
DeCS
pronóstico | púrpura | tasa de supervivencia | estudios de seguimiento | estudios retrospectivos | mediana edad | adulto | benzoatos | hidracinas | pirazoles | anciano | proteínas de fusión recombinantes | adulto joven | humanos | trombopoyetinaMeSH
Purpura | Adult | Middle Aged | Thrombopoietin | Benzoates | Follow-Up Studies | Survival Rate | Hydrazines | Humans | Pyrazoles | Recombinant Fusion Proteins | Young Adult | Aged | Retrospective Studies | PrognosisResumen
Very few data exist on when a particular thrombopoietin-receptor agonist (TPO-RA) is favored in clinical practice for the treatment of patients with immune thrombocytopenia (ITP), about novel risk factors for vascular events (VE) with these drugs, nor about predictive factors for therapy free responses (TFR). We conducted an observational, retrospective, long-term follow-up multicenter study from November 2016 to January 2018 of 121 adult ITP patients initiating TPO-RA between January 2012 to December 2014. Data reflected that a platelet count </=25 x 10(9)/l at the time when the TPO-RA was initiated was associated with a 2.8 higher probability of receiving romiplostim vs. eltrombopag (P = 0.010). VE on TPO-RA was related to previous neoplasia in patients over 65 years (50% vs. 2.2%, P < 0.001), and to previous splenectomy in younger patients (100% vs. 33%, P = 0.001). Receiving romiplostim as first TPO-RA with no subsequent TPO-RA switching was associated with a 50% likelihood of TFR after 2.9 years of therapy (3.3 years in chronic ITP patients). These real-world data help deciphering some areas of uncertainty, and offer insight into some of the most relevant challenges of ITP which may help clinicians make appropriate treatment decisions in the management of adult ITP patients with TPO-RA.
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