Chemotherapy management for unfit patients with metastatic castration-resistant prostate cancer
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Identificadores
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Fecha de publicación
2019Título de revista
Clinical & Translational Oncology
Tipo de contenido
Artigo
DeCS
protocolos de quimioterapia antineoplásica combinada | anciano | neoplasias de la próstata | algoritmos | aptitud física | grado de actividad de Karnofsky | humanosMeSH
Humans | Karnofsky Performance Status | Prostatic Neoplasms | Physical Fitness | Aged | Antineoplastic Combined Chemotherapy Protocols | AlgorithmsResumen
Administration of chemotherapy in prostate cancer depends on patient fitness. In unfit patients, physiological impairment determines the optimum treatment. Although no consensus on assessing patient fitness currently exists, this article proposes an algorithm combining the available information for administering chemotherapy, and in particular docetaxel, in unfit patients. It was constructed by reviewing factors that can influence treatment, such as performance status, taxane-related comorbidities and nutritional status. Geriatric scales for prostate cancer patients and alternative treatment regimens for this population are also reviewed. In summary, patients require overall assessment to optimise treatment. Use of docetaxel should be restricted in unfit patients, and other options must be evaluated, because of high toxicity and low efficacy.
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